Surface Electrical Impedance Myography Detects Skeletal Muscle Atrophy in Aged Wildtype Zebrafish and Aged gpr27 Knockout Zebrafish
Rutkove S, Chen Z, Pandeya S, Callegari S, Mourey T, Nagy J, Nath A. Surface Electrical Impedance Myography Detects Skeletal Muscle Atrophy in Aged Wildtype Zebrafish and Aged gpr27 Knockout Zebrafish. Biomedicines 2023, 11: 1938. PMID: 37509577, PMCID: PMC10377526, DOI: 10.3390/biomedicines11071938.Peer-Reviewed Original ResearchMuscle atrophySkeletal muscle healthG protein-coupled receptorsField of sarcopeniaAssociated with riskSkeletal muscle massAll-cause mortalityDetect muscle atrophyWorld's population agesOlder adultsSkeletal muscle atrophyAtrophy of skeletal muscleHealthcare systemMuscle healthOrphan G protein-coupled receptorAge-related conditionsElectrical impedance myographyMuscle massSarcopeniaAging StudyEconomic burdenPopulation agingKO animalsCardiovascular diseaseMyofiber atrophyElectrical impedance myography detects age-related skeletal muscle atrophy in adult zebrafish
Rutkove S, Callegari S, Concepcion H, Mourey T, Widrick J, Nagy J, Nath A. Electrical impedance myography detects age-related skeletal muscle atrophy in adult zebrafish. Scientific Reports 2023, 13: 7191. PMID: 37137956, PMCID: PMC10156759, DOI: 10.1038/s41598-023-34119-6.Peer-Reviewed Original ResearchConceptsAge-related skeletal muscle atrophyMuscle functionLoss of muscle massAssociated with fallsSkeletal muscle atrophyEvaluate potential therapeuticsSkeletal muscle functionTotal muscle areaMechanism of muscle degenerationClinical studiesMuscle atrophyMuscle degenerationMuscle healthMuscle massElectrical impedance myographyReplication cohortBioelectric propertiesFunctional declineNeuromuscular disordersSkeletal muscleDisease mechanismsImpedance myographySarcopeniaMuscle areaAge-related deficits