Heterogenous lung inflammation CT patterns distinguish pneumonia and immune checkpoint inhibitor pneumonitis and complement blood biomarkers in acute myeloid leukemia: proof of concept
Aminu M, Daver N, Godoy M, Shroff G, Wu C, Torre-Sada L, Goizueta A, Shannon V, Faiz S, Altan M, Garcia-Manero G, Kantarjian H, Ravandi-Kashani F, Kadia T, Konopleva M, DiNardo C, Pierce S, Naing A, Kim S, Kontoyiannis D, Khawaja F, Chung C, Wu J, Sheshadri A. Heterogenous lung inflammation CT patterns distinguish pneumonia and immune checkpoint inhibitor pneumonitis and complement blood biomarkers in acute myeloid leukemia: proof of concept. Frontiers In Immunology 2023, 14: 1249511. PMID: 37841255, PMCID: PMC10570510, DOI: 10.3389/fimmu.2023.1249511.Peer-Reviewed Original ResearchConceptsImmune checkpoint inhibitorsGround-glass opacitiesBlood biomarkersImmune checkpoint inhibitor pneumonitisCheckpoint inhibitor pneumonitisAcute myeloid leukemiaPost-test probabilityCheckpoint inhibitorsMyeloid leukemiaCT patternsLung inflammationPneumonitisInfected lungsRelevant blood biomarkersDiagnostic valueLung parenchymaPneumoniaCT imagesBloodBiomarkersPatientsHabitat imagesBlood modelDetection of pneumoniaLeukemiaA Nasal Inflammatory Cytokine Signature Is Associated with Early Graft-versus-Host Disease of the Lung after Allogeneic Hematopoietic Cell Transplantation: Proof of Concept
Ostrin E, Rider N, Alousi A, Irajizad E, Li L, Peng Q, Kim S, Bashoura L, Arain M, Noor L, Patel N, Mehta R, Popat U, Hosing C, Jenq R, Rondon G, Hanash S, Paczesny S, Shpall E, Champlin R, Dickey B, Sheshadri A. A Nasal Inflammatory Cytokine Signature Is Associated with Early Graft-versus-Host Disease of the Lung after Allogeneic Hematopoietic Cell Transplantation: Proof of Concept. ImmunoHorizons 2023, 7: 421-430. PMID: 37289498, PMCID: PMC10491477, DOI: 10.4049/immunohorizons.2300031.Peer-Reviewed Original ResearchConceptsBronchiolitis obliterans syndromeHematopoietic cell transplantationGraft-versus-host diseaseHematopoietic cell transplant recipientsTransient impairmentCell transplantationNasal inflammationNew-onset bronchiolitis obliterans syndromeChronic graft-versus-host diseaseMultiplex magnetic bead immunoassayNasal mucosal lining fluidAllogeneic hematopoietic cell transplantationMucosal lining fluidInflammatory cytokine signatureType 2 inflammationT cell activationMagnetic bead immunoassayNasal inflammatory responseRespiratory tract inflammationCounterregulatory moleculesBetween-group differencesIL-17ACytokine signatureBead immunoassayClinical criteria