A Nasal Inflammatory Cytokine Signature Is Associated with Early Graft-versus-Host Disease of the Lung after Allogeneic Hematopoietic Cell Transplantation: Proof of Concept
Ostrin E, Rider N, Alousi A, Irajizad E, Li L, Peng Q, Kim S, Bashoura L, Arain M, Noor L, Patel N, Mehta R, Popat U, Hosing C, Jenq R, Rondon G, Hanash S, Paczesny S, Shpall E, Champlin R, Dickey B, Sheshadri A. A Nasal Inflammatory Cytokine Signature Is Associated with Early Graft-versus-Host Disease of the Lung after Allogeneic Hematopoietic Cell Transplantation: Proof of Concept. ImmunoHorizons 2023, 7: 421-430. PMID: 37289498, PMCID: PMC10491477, DOI: 10.4049/immunohorizons.2300031.Peer-Reviewed Original ResearchMeSH KeywordsBronchiolitis ObliteransBronchiolitis Obliterans SyndromeCytokinesGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHumansInflammationLungLung TransplantationConceptsBronchiolitis obliterans syndromeHematopoietic cell transplantationGraft-versus-host diseaseHematopoietic cell transplant recipientsTransient impairmentCell transplantationNasal inflammationNew-onset bronchiolitis obliterans syndromeChronic graft-versus-host diseaseMultiplex magnetic bead immunoassayNasal mucosal lining fluidAllogeneic hematopoietic cell transplantationMucosal lining fluidInflammatory cytokine signatureType 2 inflammationT cell activationMagnetic bead immunoassayNasal inflammatory responseRespiratory tract inflammationCounterregulatory moleculesBetween-group differencesIL-17ACytokine signatureBead immunoassayClinical criteria