2017
Mitochondrial ROS activates ERK/autophagy pathway as a protected mechanism against deoxypodophyllotoxin-induced apoptosis
Kim SH, Kim KY, Park SG, Yu SN, Kim YW, Nam HW, An HH, Kim YW, Ahn SC. Mitochondrial ROS activates ERK/autophagy pathway as a protected mechanism against deoxypodophyllotoxin-induced apoptosis. Oncotarget 2017, 5: 111581-111596. PMID: 29340076, PMCID: PMC5762344, DOI: 10.18632/oncotarget.22875.Peer-Reviewed Original ResearchMitochondrial reactive oxygen speciesReactive oxygen speciesCell death responseMultiple cellular processesProtein 1 light chain 3Apoptotic prostate cancer cellsSelective fluorescent dyeMicrotubule-associated protein 1 light chain 3Acidic vesicular organellesMitochondrial membrane potentialG2/M cell cycle arrestM cell cycle arrestCell cycle arrestLight chain 3LC3 knockdownCellular processesDeath responseInhibition of autophagyApoptosis-related proteinsVesicular organellesAutophagy pathwayMolecular mechanismsCellular responsesProstate cancer cell linesProstate cancer cells
2015
Autophagy inhibition enhances silibinin-induced apoptosis by regulating reactive oxygen species production in human prostate cancer PC-3 cells
Kim S, Kim K, Yu S, Park S, Choi H, Ji J, Ahn S. Autophagy inhibition enhances silibinin-induced apoptosis by regulating reactive oxygen species production in human prostate cancer PC-3 cells. Biochemical And Biophysical Research Communications 2015, 468: 151-156. PMID: 26522224, DOI: 10.1016/j.bbrc.2015.10.143.Peer-Reviewed Original ResearchConceptsPC-3 cellsProstate cancer PC-3 cellsCancer PC-3 cellsAcidic vesicular organellesSilibinin-induced apoptosisReactive oxygen speciesAnticancer effectsHuman prostate cancer PC-3 cellsMicrotubule-associated protein 1 light chain 3Inhibition of ROSProtein 1 light chain 3Major bioactive componentsInhibition of autophagyReactive oxygen species productionCancer cell linesLight chain 3Supportive therapyLiver conditionsOxygen species productionCancer modelProtective roleSilibininSilibinin-induced autophagyROS inhibitorChain 3