2016
Salinomycin simultaneously induces apoptosis and autophagy through generation of reactive oxygen species in osteosarcoma U2OS cells
Kim S, Choi Y, Kim K, Yu S, Seo Y, Chun S, Noh K, Suh J, Ahn S. Salinomycin simultaneously induces apoptosis and autophagy through generation of reactive oxygen species in osteosarcoma U2OS cells. Biochemical And Biophysical Research Communications 2016, 473: 607-613. PMID: 27033598, DOI: 10.1016/j.bbrc.2016.03.132.Peer-Reviewed Original ResearchConceptsAcidic vesicular organellesReactive oxygen speciesMitochondrial membrane potentialChange of MMPOsteosarcoma U2OS cellsInhibition of autophagyU2OS cellsExpression of apoptosisCancer cell linesOxygen speciesFlow cytometryWestern blottingCaspase-3Cancer therapyVesicular organellesPoly (ADP-ribose) polymerase
2015
Salinomycin enhances doxorubicin-induced cytotoxicity in multidrug resistant MCF-7/MDR human breast cancer cells via decreased efflux of doxorubicin
KIM K, KIM S, YU S, PARK S, CHOI H, YU H, JI J, SEO Y, AHN S. Salinomycin enhances doxorubicin-induced cytotoxicity in multidrug resistant MCF-7/MDR human breast cancer cells via decreased efflux of doxorubicin. Molecular Medicine Reports 2015, 12: 1898-1904. PMID: 25892525, PMCID: PMC4464330, DOI: 10.3892/mmr.2015.3633.Peer-Reviewed Original ResearchConceptsEfflux of doxorubicinMCF-7/MDR cellsHuman breast cancer cellsBreast cancer cellsMultidrug resistanceMDR cellsCancer cellsReverses multidrug resistanceDose-dependent mannerMDR cancer therapyResistance of doxorubicinHuman multidrug resistanceNet cellular uptakeMDR-1Chemotherapeutic agentsMRP-1Cytometric analysisProtein levelsCancer therapyDoxorubicinExpression levelsAnticancer propertiesSalinomycinPresent studyEfflux