2017
Mitochondrial ROS activates ERK/autophagy pathway as a protected mechanism against deoxypodophyllotoxin-induced apoptosis
Kim SH, Kim KY, Park SG, Yu SN, Kim YW, Nam HW, An HH, Kim YW, Ahn SC. Mitochondrial ROS activates ERK/autophagy pathway as a protected mechanism against deoxypodophyllotoxin-induced apoptosis. Oncotarget 2017, 5: 111581-111596. PMID: 29340076, PMCID: PMC5762344, DOI: 10.18632/oncotarget.22875.Peer-Reviewed Original ResearchMitochondrial reactive oxygen speciesReactive oxygen speciesCell death responseMultiple cellular processesProtein 1 light chain 3Apoptotic prostate cancer cellsSelective fluorescent dyeMicrotubule-associated protein 1 light chain 3Acidic vesicular organellesMitochondrial membrane potentialG2/M cell cycle arrestM cell cycle arrestCell cycle arrestLight chain 3LC3 knockdownCellular processesDeath responseInhibition of autophagyApoptosis-related proteinsVesicular organellesAutophagy pathwayMolecular mechanismsCellular responsesProstate cancer cell linesProstate cancer cellsSalinomycin induces endoplasmic reticulum stress-mediated autophagy and apoptosis through generation of reactive oxygen species in human glioma U87MG cells
Yu S, Kim S, Kim K, Ji J, Seo Y, Yu H, Ahn S. Salinomycin induces endoplasmic reticulum stress-mediated autophagy and apoptosis through generation of reactive oxygen species in human glioma U87MG cells. Oncology Reports 2017, 37: 3321-3328. PMID: 28498472, DOI: 10.3892/or.2017.5615.Peer-Reviewed Original ResearchConceptsReactive oxygen speciesER stressHuman glioma U87MG cellsEndoplasmic reticulumGlioma U87MG cellsU87MG cellsStress-related proteinsAcidic vesicular organellesOxygen speciesER stress-related proteinsHuman cancer cellsAutophagy marker proteinsVesicular organellesImpact of salinomycinEndoplasmic reticulum stress-mediated autophagyMolecular mechanismsCell deathAutophagyMarker proteinsAutophagy inhibitorCancer cell linesGlioma cancer cell linesInduced apoptosisROS scavengerExpression levels
2016
Salinomycin simultaneously induces apoptosis and autophagy through generation of reactive oxygen species in osteosarcoma U2OS cells
Kim S, Choi Y, Kim K, Yu S, Seo Y, Chun S, Noh K, Suh J, Ahn S. Salinomycin simultaneously induces apoptosis and autophagy through generation of reactive oxygen species in osteosarcoma U2OS cells. Biochemical And Biophysical Research Communications 2016, 473: 607-613. PMID: 27033598, DOI: 10.1016/j.bbrc.2016.03.132.Peer-Reviewed Original ResearchConceptsAcidic vesicular organellesReactive oxygen speciesMitochondrial membrane potentialChange of MMPOsteosarcoma U2OS cellsInhibition of autophagyU2OS cellsExpression of apoptosisCancer cell linesOxygen speciesFlow cytometryWestern blottingCaspase-3Cancer therapyVesicular organellesPoly (ADP-ribose) polymerase
2015
Autophagy inhibition enhances silibinin-induced apoptosis by regulating reactive oxygen species production in human prostate cancer PC-3 cells
Kim S, Kim K, Yu S, Park S, Choi H, Ji J, Ahn S. Autophagy inhibition enhances silibinin-induced apoptosis by regulating reactive oxygen species production in human prostate cancer PC-3 cells. Biochemical And Biophysical Research Communications 2015, 468: 151-156. PMID: 26522224, DOI: 10.1016/j.bbrc.2015.10.143.Peer-Reviewed Original ResearchConceptsPC-3 cellsProstate cancer PC-3 cellsCancer PC-3 cellsAcidic vesicular organellesSilibinin-induced apoptosisReactive oxygen speciesAnticancer effectsHuman prostate cancer PC-3 cellsMicrotubule-associated protein 1 light chain 3Inhibition of ROSProtein 1 light chain 3Major bioactive componentsInhibition of autophagyReactive oxygen species productionCancer cell linesLight chain 3Supportive therapyLiver conditionsOxygen species productionCancer modelProtective roleSilibininSilibinin-induced autophagyROS inhibitorChain 3