2023
Human Uterine Lavage: First Live Births from In Vivo Conceived Genetically Screened Blastocysts
Najmabadi S, Rivas J, Angle M, Nadal A, Bastu E, Munné S, Carson S, Buster J, Nakajima S. Human Uterine Lavage: First Live Births from In Vivo Conceived Genetically Screened Blastocysts. Advances In Therapy 2023, 40: 2534-2541. PMID: 36988819, DOI: 10.1007/s12325-023-02486-1.Peer-Reviewed Original ResearchConceptsFirst live birthEmbryo transfer proceduresLive birthsUterine lavageIntrauterine inseminationEuploid blastocystsOvarian stimulation cyclesObservational case seriesBlastocyst implantation ratePreimplantation genetic testingSets of twinsInfertile womenCase seriesLavage catheterImplantation rateTransfer procedureFertility centerOocyte aspirationStimulation cyclesInfertile couplesLavage procedureSurgical proceduresEmbryo implantationMethodsIn vivoOocyte donors
2009
FOREWORD
CARSON S, WIGGINS D. FOREWORD. Clinical Obstetrics & Gynecology 2009, 52: 654-655. PMID: 20393416, DOI: 10.1097/grf.0b013e3181bf4773.Peer-Reviewed Original ResearchStress, workload, sexual well‐being and quality of life among physician residents in training
Sangi‐Haghpeykar H, Ambani D, Carson S. Stress, workload, sexual well‐being and quality of life among physician residents in training. International Journal Of Clinical Practice 2009, 63: 462-467. PMID: 19222631, DOI: 10.1111/j.1742-1241.2008.01845.x.Peer-Reviewed Original ResearchConceptsQuality of lifeSexual healthSexual dysfunctionMedical residentsNormal sexual functioningYears of residencySexual functioningPhysician residentsFemale residentsMale residentsSexual lifeMajority of residentsSexual activityHigh levelsFemale medical residentsDysfunctionMost domainsImpact of stressResidency programsHealthLevel of stressSignificant improvementResidencyQuestionnaireResidents
2005
Quantitative DNA perturbations of p53 in endometriosis: analysis of American and Icelandic cases
Gylfason J, Dang D, Petursdottir V, Benediktsdottir K, Geirsson R, Poindexter A, Mitchell-Leef D, Buster J, Carson S, Simpson J, Bischoff F. Quantitative DNA perturbations of p53 in endometriosis: analysis of American and Icelandic cases. Fertility And Sterility 2005, 84: 1388-1394. PMID: 16275233, DOI: 10.1016/j.fertnstert.2005.05.031.Peer-Reviewed Original ResearchConceptsPolymerase chain reactionUnaffected controlsSevere stage endometriosisReal-time polymerase chain reactionFresh surgical tissuesSevere endometriosisEndometriotic tissueMAIN OUTCOMEQuantitative aberrationsControl bloodSurgical tissuesP53 valuesTissue specimensLocus alterationsEndometriosisP53 lossP53 gainChain reactionSignificant differencesGAPDH controlTissueP53Copy numberAmerican subjectsComparative genomic hybridization of ectopic pregnancies that fail methotrexate therapy
McKenzie L, El-Zimaity H, Krotz S, Laucirica R, Carson S, Buster J. Comparative genomic hybridization of ectopic pregnancies that fail methotrexate therapy. Fertility And Sterility 2005, 84: 1517-1519. PMID: 16275259, DOI: 10.1016/j.fertnstert.2005.04.064.Peer-Reviewed Original ResearchPrevalence of premature urinary luteinizing hormone surges in women with regular menstrual cycles and its effect on implantation of frozen-thawed embryos
Krotz S, McKenzie L, Cisneros P, Buster J, Amato P, Carson S. Prevalence of premature urinary luteinizing hormone surges in women with regular menstrual cycles and its effect on implantation of frozen-thawed embryos. Fertility And Sterility 2005, 83: 1742-1744. PMID: 15950645, DOI: 10.1016/j.fertnstert.2004.11.078.Peer-Reviewed Original ResearchConceptsPremature LH surgeRegular menstrual cyclesFrozen embryo transferLH surgeEmbryo transferUrinary LHMenstrual cyclePregnancy rateNatural cycle frozen embryo transferFrozen-thawed embryo transferAssisted reproductive technology programRetrospective cohort studyReproductive technology programFrozen-thawed embryosCohort studyPregnancy outcomesMenstruating womenHormone surgePremature LHMAIN OUTCOMEMedical CollegePrivate medical collegeLHWomenRIA kitAlgorithm to predict assisted reproductive technology pregnancy outcome reveals minimal embryo synergy
Torsky S, Amato P, Cisneros P, Sangi-Haghpeykar H, Trukhacheva E, Carson S. Algorithm to predict assisted reproductive technology pregnancy outcome reveals minimal embryo synergy. Fertility And Sterility 2005, 83: 782-784. PMID: 15749519, DOI: 10.1016/j.fertnstert.2004.10.028.Peer-Reviewed Original ResearchPreimplantation Genetic Diagnosis (PGD) for Heritable Neoplasia
Simpson J, Carson S, Cisneros P. Preimplantation Genetic Diagnosis (PGD) for Heritable Neoplasia. JNCI Monographs 2005, 2005: 87-90. PMID: 15784832, DOI: 10.1093/jncimonographs/lgi027.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiopsyBlastocystBlastomeresCord Blood Stem Cell TransplantationEmbryo TransferFemaleGenetic CounselingGenetic Diseases, InbornGenetic Predisposition to DiseaseGenotypeHLA AntigensHumansInfant, NewbornMaleNeoplasmsPregnancyPregnancy OutcomePreimplantation DiagnosisTruth DisclosureWillsConceptsAdenomatous polyposis coliPreimplantation genetic diagnosisMolecular basisGenetic diagnosisMendelian disordersMendelian formsPolyposis coliEmbryosVon Hippel-Lindau syndromeMore cellsLi-Fraumeni syndromeGametesGenesPolar body biopsyDNADays postconceptionColiTransfer of embryosBlastocystsTrophectoderm biopsyStem cell implantationBRCA1Specific HLA genotypesGenotypesCells
2004
Human cumulus granulosa cell gene expression: a predictor of fertilization and embryo selection in women undergoing IVF
McKenzie L, Pangas S, Carson S, Kovanci E, Cisneros P, Buster J, Amato P, Matzuk M. Human cumulus granulosa cell gene expression: a predictor of fertilization and embryo selection in women undergoing IVF. Human Reproduction 2004, 19: 2869-2874. PMID: 15471935, DOI: 10.1093/humrep/deh535.Peer-Reviewed Original ResearchAdultC-Reactive ProteinCyclooxygenase 2Embryo, MammalianFemaleFertilization in VitroGene ExpressionGlucuronosyltransferaseGranulosa CellsHumansHyaluronan SynthasesIntercellular Signaling Peptides and ProteinsMembrane ProteinsPredictive Value of TestsPregnancyPregnancy RateProstaglandin-Endoperoxide SynthasesROC CurveSerum Amyloid P-ComponentAppearance of uterine perforation by hysterosalpingography
McKenzie L, Kovanci E, Amato P, Buster J, Carson S. Appearance of uterine perforation by hysterosalpingography. Fertility And Sterility 2004, 82: 1428-1429. PMID: 15533371, DOI: 10.1016/j.fertnstert.2004.07.926.Peer-Reviewed Original ResearchCharacterizing ectopic pregnancies that rupture despite treatment with methotrexate
Dudley P, Heard M, Sangi-Haghpeykar H, Carson S, Buster J. Characterizing ectopic pregnancies that rupture despite treatment with methotrexate. Fertility And Sterility 2004, 82: 1374-1378. PMID: 15533363, DOI: 10.1016/j.fertnstert.2004.03.066.Peer-Reviewed Original ResearchConceptsTubal ruptureEctopic pregnancyRisk factorsHCG valuesHuman chorionic gonadotropin valuesRetrospective case-control analysisIndependent risk factorUrban medical centerCase-control analysisConcentrations of hCGEctopic gestationMTX administrationIndependent predictorsSurgical interventionGonadotropin valuesHCG concentrationsMAIN OUTCOMEMedical CenterMethotrexateImplantation sitesPregnancyTubal isthmusPatientsPredictive variablesTreatmentAbsence of secretory endometrium after false-positive home urine luteinizing hormone testing
McGovern P, Myers E, Silva S, Coutifaris C, Carson S, Legro R, Schlaff W, Carr B, Steinkampf M, Giudice L, Leppert P, Diamond M, Network N. Absence of secretory endometrium after false-positive home urine luteinizing hormone testing. Fertility And Sterility 2004, 82: 1273-1277. PMID: 15533341, DOI: 10.1016/j.fertnstert.2004.03.070.Peer-Reviewed Original ResearchConceptsProportion of casesEndometrial biopsyProliferative endometriumLH testingHealth/National InstituteReproductive Medicine NetworkEvaluation of infertilityRegular menstrual cyclesAdditional confirmatory testingMulticenter clinical trialLate luteal phaseNational InstituteFalse-positive testsInfertile womenHormone testingSecretory endometriumMenstrual cycleClinical trialsLH testLuteal phaseInfertile couplesMAIN OUTCOMEChild healthFertile volunteersClinical practiceHistological dating of timed endometrial biopsy tissue is not related to fertility status
Coutifaris C, Myers E, Guzick D, Diamond M, Carson S, Legro R, McGovern P, Schlaff W, Carr B, Steinkampf M, Silva S, Vogel D, Leppert P, Network N. Histological dating of timed endometrial biopsy tissue is not related to fertility status. Fertility And Sterility 2004, 82: 1264-1272. PMID: 15533340, DOI: 10.1016/j.fertnstert.2004.03.069.Peer-Reviewed Original ResearchConceptsLate luteal phaseHistological datingInfertile couplesPhase biopsiesLuteal phaseCycle dayDaily urinary LH testingReproductive Medicine NetworkUrinary LH testingProspective multicenter studyRegular menstrual cyclesRecurrent pregnancy lossHistory of infertilityEndometrial biopsy tissueLogistic regression modelsInfertile womenInfertility practiceLH surgeMulticenter studyRegular intercourseBiopsy resultsPregnancy lossMenstrual cycleInclusion criteriaLive birthsPregnancy outcome of in vitro fertilization/intracytoplasmic sperm injection with profound teratospermia
McKenzie L, Kovanci E, Amato P, Cisneros P, Lamb D, Carson S. Pregnancy outcome of in vitro fertilization/intracytoplasmic sperm injection with profound teratospermia. Fertility And Sterility 2004, 82: 847-849. PMID: 15482758, DOI: 10.1016/j.fertnstert.2004.03.054.Peer-Reviewed Original ResearchConceptsIntracytoplasmic sperm injectionIVF/intracytoplasmic sperm injectionPregnancy outcomesSperm injectionFertilization/intracytoplasmic sperm injectionIVF/ICSI cyclesTertiary care centerAppropriate developmental milestonesBirth defectsStrict criteriaTime of deliveryKruger's strict criteriaYears of ageAcceptable pregnancy ratesOvarian stimulationICSI cyclesIncreased riskCare centerPregnancy rateRetrospective analysisMAIN OUTCOMETransvaginal aspirationEmbryo transferInfant statusSmall seriesNuclear chromosomal localization in human preimplantation embryos: correlation with aneuploidy and embryo morphology
McKenzie L, Carson S, Marcelli S, Rooney E, Cisneros P, Torskey S, Buster J, Simpson J, Bischoff F. Nuclear chromosomal localization in human preimplantation embryos: correlation with aneuploidy and embryo morphology. Human Reproduction 2004, 19: 2231-2237. PMID: 15298970, DOI: 10.1093/humrep/deh391.Peer-Reviewed Original ResearchConceptsChromosome 13Aneuploid blastomeresOrganization of chromosomesLocalization of chromosomesRegulatory protein functionHuman preimplantation embryosChromosome localizationChromosomal localizationProtein functionTranscriptional activityPreimplantation embryosChromosomesStage embryosEmbryo morphologyNormal blastomeresBlastomeresEmbryosHuman blastomeresSitu hybridizationSpatial organizationAbnormal embryosPreimplantation genetic diagnosisLocalizationGenetic diagnosisPaternal gonadal mosaicism detected in a couple with recurrent abortions undergoing PGD: FISH analysis of sperm nuclei proves valuable
Somprasit C, Aguinaga M, Cisneros P, Torsky S, Carson S, Buster J, Amato P, McAdoo S, Simpson J, Bischoff F. Paternal gonadal mosaicism detected in a couple with recurrent abortions undergoing PGD: FISH analysis of sperm nuclei proves valuable. Reproductive BioMedicine Online 2004, 9: 225-230. PMID: 15333256, DOI: 10.1016/s1472-6483(10)62134-7.Peer-Reviewed Original ResearchConceptsPaternal gonadal mosaicismSpontaneous abortionPreimplantation genetic diagnosisIVF-PGD cyclesRecurrent spontaneous abortionGonadal mosaicismIVF cyclesPaternal germ cellsPeripheral bloodRecurrent abortionCase reportPGD cyclesNormal karyotypeFemale partnersAbortionGenetic diagnosisIVFCytogenetic studiesDown syndrome critical regionGerm cellsUnexpected findingSitu hybridizationNormal embryosMosaicism
2003
A mutated progesterone receptor allele is more prevalent in unexplained infertility
Pisarska M, Carson S, Casson P, Tong X, Buster J, Kieback D. A mutated progesterone receptor allele is more prevalent in unexplained infertility. Fertility And Sterility 2003, 80: 651-653. PMID: 12969718, DOI: 10.1016/s0015-0282(03)00755-6.Peer-Reviewed Original ResearchPreimplantation genetic diagnosis for a known cryptic translocation: Follow‐up clinical report and implication of segregation products
McKenzie L, Cisneros P, Torsky S, Bacino C, Buster J, Carson S, Simpson J, Bischoff F. Preimplantation genetic diagnosis for a known cryptic translocation: Follow‐up clinical report and implication of segregation products. American Journal Of Medical Genetics Part A 2003, 121A: 56-59. PMID: 12900903, DOI: 10.1002/ajmg.a.20159.Peer-Reviewed Original ResearchConceptsPreimplantation genetic diagnosisCryptic translocationMaternal age-related aneuploidyAge-related aneuploidyGenetic diagnosisChromosome 17 centromere probeSevere mental retardationChorionic villus samplingUnbalanced productsPregnancy terminationClinical reportsEmpiric riskVillus samplingTransferable embryosMental retardationFrequent modeNormal offspringDiagnosisChildrenReportTranslocationUnbalanced segregantsGenetics of endometriosis
Simpson J, Bischoff F, Kamat A, Buster J, Carson S. Genetics of endometriosis. Obstetrics And Gynecology Clinics Of North America 2003, 30: 21-40. PMID: 12699256, DOI: 10.1016/s0889-8545(02)00051-7.Peer-Reviewed Original Research
2002
Pregnancies following use of metformin for ovulation induction in patients with polycystic ovary syndrome
Heard M, Pierce A, Carson S, Buster J. Pregnancies following use of metformin for ovulation induction in patients with polycystic ovary syndrome. Fertility And Sterility 2002, 77: 669-673. PMID: 11937113, DOI: 10.1016/s0015-0282(01)03266-6.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeOvary syndromeSpontaneous abortionDiagnosis of PCOSAnovulatory infertility patientsUse of metforminResumption of mensesGastrointestinal-related side effectsEvidence of ovulationDosage of metforminAnovulatory patientsMetformin therapyPCOS resultsClomiphene citrateOvulation inductionPregnancy outcomesSpontaneous mensesInfertility patientsCase seriesMedian timeOvulatory responseMAIN OUTCOMESide effectsPatientsMetformin