2015
BCL-2 family member BOK promotes apoptosis in response to endoplasmic reticulum stress
Carpio MA, Michaud M, Zhou W, Fisher JK, Walensky LD, Katz SG. BCL-2 family member BOK promotes apoptosis in response to endoplasmic reticulum stress. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 7201-7206. PMID: 26015568, PMCID: PMC4466744, DOI: 10.1073/pnas.1421063112.Peer-Reviewed Original ResearchConceptsB-cell lymphoma 2 ovarian killerApoptotic defectsMultidomain proapoptotic proteins BaxApoptotic responseStress stimuliER stressBcl-2 family proteinsER stress agentsUnfolded protein responseMouse embryonic fibroblastsDefective apoptotic responseMitochondrial apoptotic pathwayProapoptotic protein BaxPredominant subcellular localizationThapsigargin-induced apoptosisEndoplasmic reticulum stressFamily proteinsDeath responseSubcellular localizationEmbryonic fibroblastsHigh homologyProtein responseApoptotic pathwayOvert phenotypeProtein Bax
2012
Brain and testicular tumors in mice with progenitor cells lacking BAX and BAK
Katz SG, Fisher JK, Correll M, Bronson RT, Ligon KL, Walensky LD. Brain and testicular tumors in mice with progenitor cells lacking BAX and BAK. Oncogene 2012, 32: 4078-4085. PMID: 22986529, PMCID: PMC3529761, DOI: 10.1038/onc.2012.421.Peer-Reviewed Original ResearchConceptsNeural progenitor cellsProapoptotic Bcl-2 family proteins BaxSubventricular zoneBcl-2 family proteins BaxProgenitor cellsLong-term pathophysiological consequencesMitochondrial outer membraneBax/BakDeletion of BaxStem cell nicheHigh-grade tumorsMultiple developmental abnormalitiesIntrinsic apoptotic pathwayOlfactory bulb regionNestin-positive cellsProgenitor cell poolCellular excessDeath stimuliLoss of functionHypercellular tumorOuter membraneTesticular tumorsCell nicheLong-term regulationApoptotic pathway