Samit Shah, MD, PhD, FACC, FSCAI
Assistant Professor of MedicineCards
About
Research
Publications
Featured Publications
Chest pain and coronary endothelial dysfunction after recovery from COVID‐19: A case series
Shah SM, Odanovic N, Kunnirickal S, Feher A, Pfau SE, Spatz ES. Chest pain and coronary endothelial dysfunction after recovery from COVID‐19: A case series. Clinical Case Reports 2022, 10: e05612. PMID: 35425611, PMCID: PMC8991764, DOI: 10.1002/ccr3.5612.Peer-Reviewed Case Reports and Technical NotesThe Challenge of Myocardial Bridging
Shah S, Quesada O, Henry T. The Challenge of Myocardial Bridging. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 100545. PMID: 39129805, PMCID: PMC11308591, DOI: 10.1016/j.jscai.2022.100545.Commentaries, Editorials and LettersComprehensive Management of ANOCA, Part 1—Definition, Patient Population, and Diagnosis JACC State-of-the-Art Review
Samuels B, Shah S, Widmer R, Kobayashi Y, Miner S, Taqueti V, Jeremias A, Albadri A, Blair J, Kearney K, Wei J, Park K, El-Farra A, Holoshitz N, Janaszek K, Kesarwani M, Lerman A, Prasad M, Quesada O, Reynolds H, Savage M, Smilowitz N, Sutton N, Sweeny J, Toleva O, Henry T, Moses J, Fearon W, Tremmel J, Network M. Comprehensive Management of ANOCA, Part 1—Definition, Patient Population, and Diagnosis JACC State-of-the-Art Review. Journal Of The American College Of Cardiology 2023, 82: 1245-1263. PMID: 37704315, DOI: 10.1016/j.jacc.2023.06.043.Peer-Reviewed Original ResearchConceptsCoronary function testingMyocardial bridgingCoronary angiographyMultiple medical providersNonobstructive coronary arteriesCoronary microvascular dysfunctionDiagnostic coronary angiographyIschemic heart diseaseInvasive coronary angiographyCoronary flow reserveCardiac catheterization laboratoryCoronary abnormalitiesCoronary vasospasmEpicardial spasmMicrocirculatory resistanceEndothelial dysfunctionMicrovascular dysfunctionHemodynamic assessmentProvocative testingCoronary arteryFunction testingPatient populationHeart diseaseJACC StateFlow reserveComprehensive Management of ANOCA, Part 2—Program Development, Treatment, and Research Initiatives JACC State-of-the-Art Review
Smilowitz N, Prasad M, Widmer R, Toleva O, Quesada O, Sutton N, Lerman A, Reynolds H, Kesarwani M, Savage M, Sweeny J, Janaszek K, El-Farra A, Holoshitz N, Park K, Albadri A, Blair J, Jeremias A, Kearney K, Kobayashi Y, Miner S, Samuels B, Shah S, Taqueti V, Wei J, Fearon W, Moses J, Henry T, Tremmel J, Network M. Comprehensive Management of ANOCA, Part 2—Program Development, Treatment, and Research Initiatives JACC State-of-the-Art Review. Journal Of The American College Of Cardiology 2023, 82: 1264-1279. PMID: 37704316, DOI: 10.1016/j.jacc.2023.06.044.Peer-Reviewed Original ResearchConceptsCoronary function testingFunction testingFuture large-scale clinical trialsLarge-scale clinical trialsNonobstructive coronary arteriesStandardized symptom assessmentMultidisciplinary care teamTreatment of anginaIndividual patient needsQuality of lifeAngina burdenTherapeutic optionsCoronary arterySymptom assessmentClinical trialsCare teamTitrate therapyPatient needsANOCAComprehensive managementTreatmentComprehensive programAnginaPatientsArteryMultimodality Evaluation of Spontaneous Coronary Artery Dissection in a Patient With Connective Tissue Disease: A Case Report
Shah T, Shah N, Baldassarre L, Freed L, Mojibian H, Shah S. Multimodality Evaluation of Spontaneous Coronary Artery Dissection in a Patient With Connective Tissue Disease: A Case Report. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 101125. PMID: 39129904, PMCID: PMC11308843, DOI: 10.1016/j.jscai.2023.101125.Peer-Reviewed Case Reports and Technical NotesIllness Perception and the Impact of a Definitive Diagnosis on Women With Ischemia and No Obstructive Coronary Artery Disease: A Qualitative Study.
Tseng L, Göç N, Schwann A, Cherlin E, Kunnirickal S, Odanovic N, Curry L, Shah S, Spatz E. Illness Perception and the Impact of a Definitive Diagnosis on Women With Ischemia and No Obstructive Coronary Artery Disease: A Qualitative Study. Circulation Cardiovascular Quality And Outcomes 2023, 16: 521-529. PMID: 37476997, DOI: 10.1161/circoutcomes.122.009834.Peer-Reviewed Original ResearchConceptsObstructive coronary artery diseaseCoronary function testingCoronary artery diseaseInvasive coronary angiographyArtery diseaseCoronary angiographyFunction testingDefinitive diagnosisYale-New Haven HospitalNon-Hispanic blacksMore patient-centered careNew Haven HospitalPatient-centered careStructured telephone interviewQuality of lifeHealth care experiencesNon-Hispanic whitesGroup of womenCoronary functionIllness perceptionsMean ageINOCAUncertain causeMultidisciplinary teamPatient careDetermining the Cause of Coronary Vasomotor Disorders in Patients With Ischemia and Nonobstructive Coronary Arteries: Design and Rationale of the DISCOVER INOCA Prospective, Multicenter Registry
Shah S, Tremmel J, Henry T, Smilowitz N, Prasad M, Kobayashi Y, Henry G, Samady H, Samuels B, Lerman A, Moses J, Pietras C, Zhang Z, Tirziu D, Parise H, Cristea E, Chamié D, Grubman D, Henrici K, Matmusaeva E, Latif N, Cigarroa N, Lansky A. Determining the Cause of Coronary Vasomotor Disorders in Patients With Ischemia and Nonobstructive Coronary Arteries: Design and Rationale of the DISCOVER INOCA Prospective, Multicenter Registry. Journal Of The Society For Cardiovascular Angiography & Interventions 2024, 3: 102046. PMID: 39132594, PMCID: PMC11308755, DOI: 10.1016/j.jscai.2024.102046.Peer-Reviewed Original ResearchCoronary function testingObstructive coronary artery diseaseCoronary artery diseaseNonobstructive coronary arteriesLong-term outcomesFollow-upVasomotor disordersEnd pointsComposite of cardiovascular deathCoronary arteryLong-term follow-upCoronary microvascular dysfunctionDiagnostic coronary angiographyCardiovascular adverse eventsAdverse cardiovascular eventsCoronary vasomotor disordersOptical coherence tomographySymptomatic myocardial bridgingShort-term end pointsAtherosclerotic plaque burdenIschemic heart diseaseLong-term end pointsINOCA patientsAcetylcholine provocationPatient-reported outcome measuresEvaluating Ischemic Heart Disease in Women: Focus on Angina With Nonobstructive Coronary Arteries (ANOCA)
Maayah M, Latif N, Vijay A, Gallegos C, Cigarroa N, Martinez E, Mazure C, Miller E, Spatz E, Shah S. Evaluating Ischemic Heart Disease in Women: Focus on Angina With Nonobstructive Coronary Arteries (ANOCA). Journal Of The Society For Cardiovascular Angiography & Interventions 2024, 3: 102195. PMID: 39166160, PMCID: PMC11330936, DOI: 10.1016/j.jscai.2024.102195.Peer-Reviewed Original ResearchIschemic heart diseaseNonobstructive coronary arteriesCoronary artery diseaseArtery diseaseObstructive coronary artery diseaseCoronary arteryLong-term cardiovascular prognosisHeart diseaseSuspected ischemic heart diseaseAtherosclerotic coronary artery diseaseCoronary vasomotor disordersPretest probability of diseasePragmatic diagnostic algorithmExpert consensus documentEvaluating ischemic heart diseaseImpact quality of lifeQuality of lifeSymptomatic patientsPretest probabilityANOCACardiovascular prognosisVasomotor disordersDiagnostic evaluationPersistent symptomsDiagnostic strategies
2024
Long-term outcomes of ischaemia with no obstructive coronary artery disease (INOCA): a systematic review and meta-analysis
Odanović N, Schwann A, Zhang Z, Kapadia S, Kunnirickal S, Parise H, Tirziu D, Ilic I, Lansky A, Pietras C, Shah S. Long-term outcomes of ischaemia with no obstructive coronary artery disease (INOCA): a systematic review and meta-analysis. Open Heart 2024, 11: e002852. PMID: 39353703, PMCID: PMC11448144, DOI: 10.1136/openhrt-2024-002852.Peer-Reviewed Original ResearchConceptsCoronary Vasomotor Disorders International Study GroupRate of MACEReduced coronary flow reserveCoronary flow reservePrognosis of patientsVasospastic anginaPatient yearsMyocardial infarctionPrimary outcomeIncidence of primary outcomeLong-term prognosis of patientsSystematic reviewMeta-analysisLong-term prognosisInternational Study GroupAdverse cardiovascular eventsLong-term outcomesImaging stress testsMeta-analysis of studiesRandom-effects modelWeb of ScienceINOCACardiovascular eventsFollow-upVasomotor disordersAssociation between 82Rb positron emission tomography-derived regional myocardial blood flow, severity of angiographic coronary artery stenosis, and mortality in patients with chest pain
Gallegos C, Paredes C, Hu J, Posada E, Saito Y, Lansky A, Shah S, Liu Y, Smolderen K, Mena-Hurtado C, Sinusas A, Miller E. Association between 82Rb positron emission tomography-derived regional myocardial blood flow, severity of angiographic coronary artery stenosis, and mortality in patients with chest pain. Advances In Radiotherapy & Nuclear Medicine 2024, 2: 3786. DOI: 10.36922/arnm.3786.Peer-Reviewed Original ResearchMyocardial flow reserveGlobal myocardial flow reserveQuantitative coronary angiographyAssociated with increased all-cause mortalityPositron emission tomographyCoronary artery stenosis severityMyocardial blood flowAll-cause mortalityCoronary angiographyChest painStenosis severityAngiographic coronary artery stenosisResting myocardial blood flowAcute chest painBlood flowInvasive coronary angiographyLeft circumflex arteryLeft descending arteryRight coronary arteryCoronary artery stenosisStress testCoronary stenosis severityCardiovascular eventsDescending arteryWeak correlation
Clinical Trials
Current Trials
The DISCOVER INOCA Prospective Multi-center Registry - Determining the Cause of Coronary Vasomotor Disorders in Patients with Ischemia and No Obstructive Coronary Artery Disease
HIC ID2000032344RolePrincipal InvestigatorPrimary Completion Date03/31/2027Recruiting ParticipantsGenderBothAge18+ years
Academic Achievements & Community Involvement
Clinical Care
Overview
Samit Shah, MD, PhD, is an interventional cardiologist who specializes in diagnosing and repairing problems with blood vessels in the heart and throughout the body. He has specific expertise in disorders of coronary physiology, or problems with the way the heart receives blood, which often leads to chest pain.
Dr. Shah initially planned to be an ear, nose, and throat surgeon and has a doctorate in neuroscience in addition to one in medicine, but he found a different calling in cardiology when his father, a primary care doctor, had a heart attack. He says he enjoys “getting to the root of challenging problems and coming up with an intervention or a medication regimen precisely tailored to each patient's condition.”
He says caring for patients with heart disease is not just about improving chances of survival, but also about quality of life, as well as open communication between the doctor and the patient. “Caring for patients with heart disease creates a special relationship between a provider and a patient; often the stakes are high, but the results can be very rewarding,” he says.
In addition to treating patients for such conditions as coronary artery disease, coronary microvascular dysfunction, and coronary vasospasm, Dr. Shah developed a program at Yale for the diagnosis of disorders of coronary physiology during invasive heart catheterization procedures. In addition, he performs advanced and complex coronary artery interventions, carotid artery interventions, and lower extremity peripheral arterial interventions.
An assistant professor at Yale School of Medicine, Dr. Shah is involved in active research projects at Yale regarding invasive coronary physiology testing, ischemic heart disease in women, and the vascular effects of psychological stress. A specific research interest is in people who have cardiac catheterization, but don’t have blockages.
Clinical Specialties
Fact Sheets
Heart Disease in Women
Learn More on Yale MedicineCoronary Artery Disease (CAD)
Learn More on Yale MedicineCoronary Atherosclerosis Treatments
Learn More on Yale MedicineAngina
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Board Certifications
Interventional Cardiology
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2019
Cardiovascular Disease
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2018
Internal Medicine
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2015
Yale Medicine News
News
News
- October 24, 2024
Carolyn M. Mazure Receives Elga R. Wasserman Award
- October 24, 2024
Women’s Health Research at Yale Welcomes Undergraduate Fellows
- August 08, 2024
Helping Women With Chest Pain Get the Right Diagnosis
- August 06, 2024
Yale Researchers at European Society of Cardiology Conference 2024