Samit Joshi, DO, MPH
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About
Titles
Assistant Clinical Professor
Biography
Dr. Joshi completed his clinical training at the Yale School of Medicine (Internal Medicine and Infectious Diseases) after which his postdoctoral translational research focused on: 1) innate immunosenescence in context of HIV-1 infection and 2) the relationship between the oral microbiome and health-care associated pneumonia.
His ongoing clinical activities as a Clinical Instructor at the Yale School of Medicine / VAMC (West Haven) and a Consultant at Waterbury Hospital continue to complement his research and developmental interests in Infectious Diseases and Immunology.
Appointments
Infectious Diseases
Assistant Clinical ProfessorPrimary
Other Departments & Organizations
Education & Training
- Postdoctoral Fellow
- Yale School of Medicine (2012)
- Fellow
- Yale School of Medicine (2011)
- Resident
- Yale School of Medicine (2008)
- MPH
- Des Moines University (2005)
- DO
- Des Moines University - Osteopathic Medical Center (2005)
- BA
- University of Minnesota (2001)
Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Samit Joshi's published research.
Publications Timeline
A big-picture view of Samit Joshi's research output by year.
Max Lataillade, MPH, DO
Peter James Krause, MD
Ruth R Montgomery, PhD
6Publications
952Citations
Publications
2023
Effects of the HIV‐1 maturation inhibitor GSK3640254 on QT interval in healthy participants
Zhang Y, Bush M, Yazdani P, Zhan J, Wen B, Bainbridge V, Wynne B, Joshi S, Lataillade M. Effects of the HIV‐1 maturation inhibitor GSK3640254 on QT interval in healthy participants. Pharmacology Research & Perspectives 2023, 11: e01151. PMID: 37961928, PMCID: PMC10644204, DOI: 10.1002/prp2.1151.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsConcentration-QTc analysisHealthy participantsQT intervalNovel HIV-1 maturation inhibitorsPlacebo-adjusted changeHIV-1 treatmentHIV-1 maturation inhibitorsMoxifloxacin doseSupratherapeutic dosePlasma concentrationsRelevant effectsFridericia's formulaTreatment periodCardiac repolarizationHeart rateMaturation inhibitorsCardiac conductionCardiac parametersDay 7QT studyDoseTime pointsGSK3640254ΔΔQTcFPharmacokinetics
2013
Top3β is an RNA topoisomerase that works with fragile X syndrome protein to promote synapse formation
Xu D, Shen W, Guo R, Xue Y, Peng W, Sima J, Yang J, Sharov A, Srikantan S, Yang J, Fox D, Qian Y, Martindale JL, Piao Y, Machamer J, Joshi SR, Mohanty S, Shaw AC, Lloyd TE, Brown GW, Ko MS, Gorospe M, Zou S, Wang W. Top3β is an RNA topoisomerase that works with fragile X syndrome protein to promote synapse formation. Nature Neuroscience 2013, 16: 1238-1247. PMID: 23912945, PMCID: PMC3853347, DOI: 10.1038/nn.3479.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAnimalsAnimals, Genetically ModifiedCells, CulturedChickensDNA Topoisomerases, Type IDrosophilaDrosophila ProteinsEmbryo, MammalianEyeFragile X Mental Retardation ProteinGene Expression RegulationHumansMiceMice, Inbred C57BLNerve Tissue ProteinsNeurogenesisNeuromuscular JunctionNeuronsRNA-Binding ProteinsTransfection
2010
Dysregulation of human Toll-like receptor function in aging
Shaw AC, Panda A, Joshi SR, Qian F, Allore HG, Montgomery RR. Dysregulation of human Toll-like receptor function in aging. Ageing Research Reviews 2010, 10: 346-353. PMID: 21074638, PMCID: PMC3633557, DOI: 10.1016/j.arr.2010.10.007.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsToll-like receptorsTLR functionImmune systemToll-like receptor functionPattern recognition receptor familyAge-associated dysregulationInnate immune systemGeriatric patientsTLR activationAnimal modelsContext of agingReceptor functionHuman cohortsInfectious diseasesReceptor familyInappropriate persistenceDysregulationRecent studiesOverarching themesAdaptive responseMorbidityImmunosenescencePatientsCohortInnateAging of the innate immune system
Shaw AC, Joshi S, Greenwood H, Panda A, Lord JM. Aging of the innate immune system. Current Opinion In Immunology 2010, 22: 507-513. PMID: 20667703, PMCID: PMC4034446, DOI: 10.1016/j.coi.2010.05.003.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsInnate immune systemImmune systemPro-inflammatory environmentInnate immune activationToll-like receptorsMonocytes/macrophagesAge-associated defectsNKT cellsDendritic cellsImmune activationElderly individualsTissue damageNetwork of cellsCell typesSignal transduction pathwaysCellsActivationEarly interactionsTransduction pathwaysImmunosenescenceNeutrophilsInfectionMacrophagesNKReceptorsEmergence of Resistance to Azithromycin-Atovaquone in Immunocompromised Patients with Babesia microti Infection
Wormser GP, Prasad A, Neuhaus E, Joshi S, Nowakowski J, Nelson J, Mittleman A, Aguero-Rosenfeld M, Topal J, Krause PJ. Emergence of Resistance to Azithromycin-Atovaquone in Immunocompromised Patients with Babesia microti Infection. Clinical Infectious Diseases 2010, 50: 381-386. PMID: 20047477, DOI: 10.1086/649859.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDrug regimenB. microtiLevel of immunosuppressionBabesia microti infectionTreatment of babesiosisDrug-resistant strainsEmergence of resistanceActive babesiosisMicrobiologic relapseLaboratory abnormalitiesDrug regimensImmunocompromised patientsOptimal therapyTreatment failureDrug therapyMicroti infectionPatientsClinical case historiesDrug resistanceBabesia microtiInfectionRegimenMicrotiEventual developmentBabesiosis
2009
Pandemic influenza H1N1 2009, innate immunity, and the impact of immunosenescence on influenza vaccine.
Joshi SR, Shaw AC, Quagliarello VJ. Pandemic influenza H1N1 2009, innate immunity, and the impact of immunosenescence on influenza vaccine. The Yale Journal Of Biology And Medicine 2009, 82: 143-51. PMID: 20027279, PMCID: PMC2794489.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsPandemic influenza H1N1 2009Influenza H1N1 2009Influenza vaccineEpidemiologic characteristicsH1N1 2009Innate immune system responseImpact of immunosenescenceInfluenza vaccine responsivenessPandemic influenza vaccineSeasonal influenza vaccinePrevention of morbidityInfluenza virus infectionShort narrative reviewImmune system responseSeroprotective responseVaccine responsivenessPandemic influenzaSeasonal influenzaEffective vaccineVirus infectionPandemic strainsNeuraminidase inhibitorsInnate immunityNarrative reviewVaccine
Academic Achievements and Community Involvement
honor Annual Meeting Travel Award and Special Citation for Oral Abstract
National AwardInfectious Diseases Society of AmericaDetails10/06/2011United Stateshonor John W. Brackett Award for Resident Teacher
Yale School of Medicine AwardYale Primary Care Residency ProgramDetails06/30/2008United Stateshonor Physician Scholar in International Health
Yale School of Medicine AwardYale School of Medicine / Johnson & JohnsonDetails06/01/2007United States
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- January 15, 2009
The lost art of the physical exam
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