2020
In vivo measurement of widespread synaptic loss in Alzheimer's disease with SV2A PET
Mecca AP, Chen M, O'Dell RS, Naganawa M, Toyonaga T, Godek TA, Harris JE, Bartlett HH, Zhao W, Nabulsi NB, Vander Wyk B, Varma P, Arnsten AFT, Huang Y, Carson RE, van Dyck C. In vivo measurement of widespread synaptic loss in Alzheimer's disease with SV2A PET. Alzheimer's & Dementia 2020, 16: 974-982. PMID: 32400950, PMCID: PMC7383876, DOI: 10.1002/alz.12097.Peer-Reviewed Original ResearchConceptsWidespread synaptic lossEarly Alzheimer's diseaseSynaptic lossAlzheimer's diseaseSynaptic vesicle glycoprotein 2AGray matter volumeMajor structural correlatePositron emission tomography (PET) imagingEmission Tomography ImagingDistribution volume ratioCerebellar reference regionNeocortical brain regionsSynaptic densityAD progressionConsistent pathologyPotential therapyMatter volumePromising biomarkerCognitive impairmentCN participantsBrain regionsDiseaseTomography imagingNormal participantsStructural correlates
2015
Reelin Prevents Apical Neurite Retraction during Terminal Translocation and Dendrite Initiation
O'Dell RS, Cameron DA, Zipfel WR, Olson EC. Reelin Prevents Apical Neurite Retraction during Terminal Translocation and Dendrite Initiation. Journal Of Neuroscience 2015, 35: 10659-10674. PMID: 26224852, PMCID: PMC4518046, DOI: 10.1523/jneurosci.1629-15.2015.Peer-Reviewed Original ResearchConceptsApical dendritesCortical laminationGlycoprotein ReelinMigration arrestPrimary neuritesMarginal zoneNormal target areaWild-type neuronsSubset of neuronsReeler cortexReeler neuronsDendritic arborsDendritic outgrowthReelin functionMouse cortexReelin proteinNeuronal migrationNeuronsLeading processCortexReelinMin periodNeurite retractionNeuritesTerminal phase
2012
Layer 6 cortical neurons require Reelin-Dab1 signaling for cellular orientation, Golgi deployment, and directed neurite growth into the marginal zone
O’Dell R, Ustine CJ, Cameron DA, Lawless SM, Williams RM, Zipfel WR, Olson EC. Layer 6 cortical neurons require Reelin-Dab1 signaling for cellular orientation, Golgi deployment, and directed neurite growth into the marginal zone. Neural Development 2012, 7: 25. PMID: 22770513, PMCID: PMC3466444, DOI: 10.1186/1749-8104-7-25.Peer-Reviewed Original ResearchConceptsEarly cortical developmentMutant cortexCortical neuronsCortical developmentPial surfaceMarginal zoneApical neuritesL6 neuronsRecombinant ReelinNeocortical neuronsNeuronal somataReelin-Dab1Arbor lengthArbor sizeExplant modelVentricular zonePioneer neuronsMutant neuronsReelinNeuronsConclusionsThese findingsMore primary processesNeuronal orientationCortexNeurite growth