2024
The role of 18F-FDG PET in minimizing variability in gross tumor volume delineation of soft tissue sarcomas
Najem E, Marin T, Zhuo Y, Lahoud R, Tian F, Beddok A, Rozenblum L, Xing F, Moteabbed M, Lim R, Liu X, Woo J, Lostetter S, Lamane A, Chen Y, Ma C, El Fakhri G. The role of 18F-FDG PET in minimizing variability in gross tumor volume delineation of soft tissue sarcomas. Radiotherapy And Oncology 2024, 194: 110186. PMID: 38412906, PMCID: PMC11042980, DOI: 10.1016/j.radonc.2024.110186.Peer-Reviewed Original ResearchGross tumor volume delineationGross tumor volumeDice similarity coefficientF-FDG PET imagingSoft tissue sarcomasInter-reader variabilityGTV delineationRadiation therapy treatment planningF-FDGF-FDG PETTherapy treatment planningPerformance level estimationTumor volume delineationTissue sarcomasPET imagingVolume delineationSimultaneous truthHausdorff distanceDice similarity coefficient scoreAccurate gross tumor volumeImaging modality groupsWilcoxon signed-rank testStatistically significant decreaseSigned-rank testTumor volume
2021
Deep learning-based GTV contouring modeling inter- and intra- observer variability in sarcomas
Marin T, Zhuo Y, Lahoud R, Tian F, Ma X, Xing F, Moteabbed M, Liu X, Grogg K, Shusharina N, Woo J, Lim R, Ma C, Chen Y, El Fakhri G. Deep learning-based GTV contouring modeling inter- and intra- observer variability in sarcomas. Radiotherapy And Oncology 2021, 167: 269-276. PMID: 34808228, PMCID: PMC8934266, DOI: 10.1016/j.radonc.2021.09.034.Peer-Reviewed Original ResearchConceptsGross tumor volumeRadiation therapy treatment planningGross tumor volume contoursGross tumor volume delineationTherapy treatment planningIntra-observer variabilityConsensus contoursGTV contoursPre-operative CT imagesSoft tissue sarcomasRadiation oncologistsTumor volumeBone sarcomasTreatment planningAccurate contoursCT imagesDelineation procedureSarcomaSoft tissueConfidence levelRadiationPatientsHausdorff distanceMultiple contoursX-ray
2014
[18F]-Fluoromisonidazole Positron Emission Tomography/Computed Tomography Visualization of Tumor Hypoxia in Patients With Chordoma of the Mobile and Sacrococcygeal Spine
Cheney M, Chen Y, Lim R, Winrich B, Grosu A, Trofimov A, Depauw N, Shih H, Schwab J, Hornicek F, DeLaney T. [18F]-Fluoromisonidazole Positron Emission Tomography/Computed Tomography Visualization of Tumor Hypoxia in Patients With Chordoma of the Mobile and Sacrococcygeal Spine. International Journal Of Radiation Oncology • Biology • Physics 2014, 90: 1030-1036. PMID: 25539367, PMCID: PMC4280072, DOI: 10.1016/j.ijrobp.2014.08.016.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCell HypoxiaChordomaFeasibility StudiesFemaleHumansMaleMiddle AgedMisonidazoleMultimodal ImagingNeoplasm Recurrence, LocalPhotonsPilot ProjectsPositron-Emission TomographyProspective StudiesProton TherapyRadiopharmaceuticalsRadiotherapy DosageRelative Biological EffectivenessSacrococcygeal RegionSpinal NeoplasmsTomography, X-Ray ComputedTumor BurdenConceptsHypoxic subvolumesGross tumor volumeFMISO PET/CTRadiation therapyLocal recurrenceTumor volumeSacrococcygeal spinePositron emission tomography/computed tomographyRT dose escalationStage T2 tumorsEmission tomography/computed tomographyStandardized uptake valueMedian follow-upTreatment of chordomasChanges to treatmentVisualization of tumor hypoxiaDose escalationT2 tumorsTomography/computed tomographyMetastatic diseaseRecurrent chordomaUptake valueClinical characteristicsTumor hypoxiaFollow-up