2022
Longitudinal Assessment of Global and Regional Left Ventricular Strain in Patients with Multisystem Inflammatory Syndrome in Children (MIS-C)
He M, Leone DM, Frye R, Ferdman DJ, Shabanova V, Kosiv KA, Sugeng L, Faherty E, Karnik R. Longitudinal Assessment of Global and Regional Left Ventricular Strain in Patients with Multisystem Inflammatory Syndrome in Children (MIS-C). Pediatric Cardiology 2022, 43: 844-854. PMID: 34993558, PMCID: PMC8739007, DOI: 10.1007/s00246-021-02796-7.Peer-Reviewed Original ResearchConceptsMIS-C patientsAcute phaseChronic phaseInflammatory syndromeTwo-dimensional speckle tracking echocardiographySubclinical myocardial injuryCircumferential strainMultisystem inflammatory syndromeLeft ventricular dysfunctionSingle-institution reviewSpeckle tracking echocardiographyTwo-dimensional echocardiographyCoronavirus disease 2019Future adverse eventsVentricular function parametersBasal anterolateral segmentMean GCSVentricular dysfunctionAdverse eventsFractional shorteningSignificant sequelaeVentricular strainMyocardial dysfunctionGlobal longitudinalMyocardial injury
2018
Abnormalities in Left Ventricular Rotation Are Inherent in Young Children with Repaired Tetralogy of Fallot and Are Independent of Right Ventricular Dilation
Karnik R, Uppu SC, Tozzi M, Doucette J, Lytrivi ID, Geiger M, Klas B, Parness IA, Shenoy R, Rajagopal H, Srivastava S. Abnormalities in Left Ventricular Rotation Are Inherent in Young Children with Repaired Tetralogy of Fallot and Are Independent of Right Ventricular Dilation. Pediatric Cardiology 2018, 39: 1172-1180. PMID: 29644405, DOI: 10.1007/s00246-018-1877-9.Peer-Reviewed Original ResearchConceptsRight ventricular dilationRV dilationAbnormal ARLV systolicPulmonary regurgitationVentricular dilationRotational mechanicsApical rotationYoung childrenAge-matched normal controlsAsymptomatic young childrenLeft ventricular dysfunctionSingle-center studyLV myocardial mechanicsTetralogy of FallotLV rotational mechanicsTwo-dimensional echocardiographyFurther longitudinal studiesLeft ventricular rotationRTOF childrenLack of maturationVentricular dysfunctionDiastolic dysfunctionDiastolic functionClinical outcomes