2019
Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation
Kato T, Pothula S, Liu RJ, Duman CH, Terwilliger R, Vlasuk GP, Saiah E, Hahm S, Duman RS. Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation. Journal Of Clinical Investigation 2019, 129: 2542-2554. PMID: 30990795, PMCID: PMC6546461, DOI: 10.1172/jci126859.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexRapid acting antidepressantsActing antidepressantsAntidepressant actionAntidepressant effectsBDNF releaseActivity-dependent BDNF releaseRapid antidepressant effectsBlood-brain barrierChronic stress exposureSynaptic deficitsBDNF polymorphismSingle doseBrain barrierSynapse numberPreclinical studiesPharmacological modulationNeuronal activityChronic stressPrefrontal cortexRapid synapticStress exposureBehavioral responsesAmino acid leucineAntidepressants
2010
Antipsychotic‐induced gene regulation in multiple brain regions
Girgenti MJ, Nisenbaum LK, Bymaster F, Terwilliger R, Duman RS, Newton SS. Antipsychotic‐induced gene regulation in multiple brain regions. Journal Of Neurochemistry 2010, 113: 175-187. PMID: 20070867, PMCID: PMC2921913, DOI: 10.1111/j.1471-4159.2010.06585.x.Peer-Reviewed Original ResearchConceptsGene regulationTranscription factorsMolecular mechanismsHigh-throughput gene profilingInduction of genesComplex molecular mechanismsGene expression studiesFuture drug development effortsNovel genesRegulated genesDrug development effortsFunctional categoriesGene inductionMicroarray approachExpression studiesG proteinsGenesReal-time PCRGene profilingNeurotransmitter signalingLimited overlapFrontal cortexSitu hybridizationRetinoic acidRegulation