2022
Effects of Ketamine Infusion on Breathing and Encephalography in Spontaneously Breathing ICU Patients
Suleiman A, Santer P, Munoz-Acuna R, Hammer M, Schaefer MS, Wachtendorf LJ, Rumyantsev S, Berra L, Chamadia S, Johnson-Akeju O, Baedorf-Kassis EN, Eikermann M. Effects of Ketamine Infusion on Breathing and Encephalography in Spontaneously Breathing ICU Patients. Journal Of Intensive Care Medicine 2022, 38: 299-306. PMID: 35934953, DOI: 10.1177/08850666221119716.Peer-Reviewed Original ResearchConceptsSpontaneous breathing trialKetamine infusionMcg/Inspiratory flowInspiratory workKey secondary endpointProspective interventional studyEnd-expiratory pressurePre-specified time pointsKetamine 10Breathing trialSecondary endpointsPrimary outcomeICU patientsIll patientsMechanical ventilationEsophageal pressureInfusion regimenInterventional studyPropofol sedationRespiratory timingResistive workAirway flowPreclinical studiesElectroencephalographic patterns
2021
Delirium
Munoz-Acuna R, O'Gara B. Delirium. 2021, 205-210. DOI: 10.1201/9781003042136-35.Peer-Reviewed Original ResearchIntensive care unitNewer atypical antipsychotic agentsLong-term cognitive functionIncidence of deliriumMechanical ventilation timeNumerous pharmacological strategiesUnderlying medical disorderAtypical antipsychotic agentsDelirium preventionICU lengthCare unitMechanical ventilationVentilation timeClinical trialsPharmacological strategiesSimilar efficacyAntipsychotic agentsMedical disordersDeliriumBehavioral disturbancesSide effectsMental disordersCognitive functionStatistical ManualExcess costs
2020
BOSTN Bundle Intervention for Perioperative Screening and Management of Patients With Suspected Obstructive Sleep Apnea: A Hospital Registry Study.
Raub D, Santer P, Nabel S, Platzbecker K, Munoz-Acuna R, Xu X, Friedrich S, Ramachandran SK, Eikermann M, Sundar E. BOSTN Bundle Intervention for Perioperative Screening and Management of Patients With Suspected Obstructive Sleep Apnea: A Hospital Registry Study. Anesthesia & Analgesia 2020, 130: 1415-1424. PMID: 31283617, DOI: 10.1213/ane.0000000000004294.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaInvasive mechanical ventilationBeth Israel Deaconess Medical CenterHospital registry studyMechanical ventilationRegistry studyPostoperative desaturationSleep apneaPeripheral oxygen saturation measurementsMinutes of extubationNoncardiac surgical casesPostoperative invasive ventilationPreoperative screening toolPostoperative mechanical ventilationKey secondary outcomesDay of surgeryManagement of patientsBody mass indexMultivariable logistic regressionHigh-risk casesLow-risk casesPatient-specific factorsClinical management pathwayOxygen saturation measurementsInvasive ventilation