2001
Characterization of a DNA-Cleaving deoxyribozyme
Carmi N, Breaker R. Characterization of a DNA-Cleaving deoxyribozyme. Bioorganic & Medicinal Chemistry 2001, 9: 2589-2600. PMID: 11557347, DOI: 10.1016/s0968-0896(01)00035-9.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceCatalysisCopperDeoxyadenosinesDeoxyribonucleotidesDNADNA, CatalyticDNA, Single-StrandedElectrophoresis, Gel, Two-DimensionalModels, MolecularMolecular StructureNucleic Acid ConformationOxidation-ReductionSequence Analysis, DNAStructure-Activity RelationshipSubstrate Specificity
2000
Molecular Recognition of cAMP by an RNA Aptamer †
Koizumi M, Breaker R. Molecular Recognition of cAMP by an RNA Aptamer †. Biochemistry 2000, 39: 8983-8992. PMID: 10913311, DOI: 10.1021/bi000149n.Peer-Reviewed Original ResearchStructural diversity of self-cleaving ribozymes
Tang J, Breaker R. Structural diversity of self-cleaving ribozymes. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 5784-5789. PMID: 10823936, PMCID: PMC18511, DOI: 10.1073/pnas.97.11.5784.Peer-Reviewed Original ResearchAltering molecular recognition of RNA aptamers by allosteric selection11Edited by D. E. Draper
Soukup G, Emilsson G, Breaker R. Altering molecular recognition of RNA aptamers by allosteric selection11Edited by D. E. Draper. Journal Of Molecular Biology 2000, 298: 623-632. PMID: 10788325, DOI: 10.1006/jmbi.2000.3704.Peer-Reviewed Original Research
1999
Phosphorylating DNA with DNA
Li Y, Breaker R. Phosphorylating DNA with DNA. Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 2746-2751. PMID: 10077582, PMCID: PMC15840, DOI: 10.1073/pnas.96.6.2746.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceDNAHydrolysisMolecular Sequence DataPhosphorylationRNASubstrate SpecificityConceptsSubstrate recognition patternRandom sequence poolsKinase-like activityStandard NTPsATP hydrolysisSpecific target DNAVitro SelectionIndividual DNAProtein enzymesDNADNTP substratesMultiple turnoversDeoxyribozymesEnzymeTarget DNABiological systemsDeoxyribose moietyGTPNTPsRNAATPDNTPsCatalytic potentialSelectionRibose
1998
Cleaving DNA with DNA
Carmi N, Balkhi S, Breaker R. Cleaving DNA with DNA. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 2233-2237. PMID: 9482868, PMCID: PMC19303, DOI: 10.1073/pnas.95.5.2233.Peer-Reviewed Original Research
1995
Self-Incorporation of coenzymes by ribozymes
Breaker R, Joyce G. Self-Incorporation of coenzymes by ribozymes. Journal Of Molecular Evolution 1995, 40: 551-558. PMID: 7643406, DOI: 10.1007/bf00160500.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCoenzymesGuanosineIntronsNADNADPRNA, CatalyticSubstrate SpecificityTetrahymena thermophilaConceptsFunctional groupsCoenzyme analoguesAdditional functional groupsChemical functional groupsChemical moietiesTransfer reactionsCovalent attachmentRNA enzymeAbsence of proteinStandard nucleotidesCatalysisCatalytic functionRibozyme activityRNA worldRibozymeMoietyAnaloguesCoenzymeCoA-SHMoleculesReaction
1994
Continuous in vitro evolution of bacteriophage RNA polymerase promoters.
Breaker R, Banerji A, Joyce G. Continuous in vitro evolution of bacteriophage RNA polymerase promoters. Biochemistry 1994, 33: 11980-6. PMID: 7522554, DOI: 10.1021/bi00205a037.Peer-Reviewed Original Research