Genome-wide significant, replicated and functional risk variants for Alzheimer’s disease
Guo X, Qiu W, Garcia-Milian R, Lin X, Zhang Y, Cao Y, Tan Y, Wang Z, Shi J, Wang J, Liu D, Song L, Xu Y, Wang X, Liu N, Sun T, Zheng J, Luo J, Zhang H, Xu J, Kang L, Ma C, Wang K, Luo X. Genome-wide significant, replicated and functional risk variants for Alzheimer’s disease. Journal Of Neural Transmission 2017, 124: 1455-1471. PMID: 28770390, PMCID: PMC5654670, DOI: 10.1007/s00702-017-1773-0.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesNon-coding RNAsRisk variantsRisk genesProtein-coding genesProtein-coding RNAsLong non-coding RNAsFunctional risk variantsPotential biological functionsAD-related pathwaysExpression of piRNAsAlterations of proteinsGenomic regionsExpression correlationBiological functionsProtein structureAssociation studiesMetabolism pathwaysLipoprotein metabolism pathwaysRisk SNPsGenesSNPsPiRNAsRNARegulatory effects