PDE‐5 inhibition improves skin flap viability in rats that are exposed to nicotine
Shah A, Pfaff MJ, Assi R, Wu W, Steinbacher DM. PDE‐5 inhibition improves skin flap viability in rats that are exposed to nicotine. Microsurgery 2014, 34: 390-397. PMID: 24610727, DOI: 10.1002/micr.22237.Peer-Reviewed Original ResearchConceptsPDE-5 inhibitionSkin flap necrosisFlap necrosisNicotine SCSkin flapsPostoperative day 1Skin flap survivalPhosphodiesterase-5 inhibitionSildenafil-treated groupSkin flap viabilityDose-dependent reductionDays of treatmentWestern blot analysisDaily groupMcFarlane flapsFlap survivalFluorescence angiographyBlood flowGroup 2Group 1Blinded observersDay 1Flap viabilityDay 7Group 3