2006
C-Reactive Protein and Vulnerability to Mental Stress-Induced Myocardial Ischemia
Shah R, Burg MM, Vashist A, Collins D, Liu J, Jadbabaie F, Graeber B, Earley C, Lampert R, Soufer R. C-Reactive Protein and Vulnerability to Mental Stress-Induced Myocardial Ischemia. Molecular Medicine 2006, 12: 269-274. PMID: 17380191, PMCID: PMC1829194, DOI: 10.2119/2006-00077.shah.Peer-Reviewed Original ResearchConceptsC-reactive proteinCoronary artery diseaseMyocardial perfusion imagingTransthoracic echocardiographyCRP levelsMental stressRisk markersMyocardial ischemiaLevels of CRPNew regional wall motion abnormalitiesAssociation of CRPRelationship of CRPSimultaneous single-photon emissionStable coronary artery diseaseUnivariate logistic regression analysisRegional wall motion abnormalitiesTetrofosmin myocardial perfusion imagingLaboratory mental stressRisk of MSISerum CRP levelsHistory of diabetesSubsequent clinical eventsNew perfusion defectsWall motion abnormalitiesLogistic regression analysis
2003
Simultaneous assessment of myocardial perfusion and function during mental stress in patients with chronic coronary artery disease
Arrighi JA, Burg M, Cohen IS, Soufer R. Simultaneous assessment of myocardial perfusion and function during mental stress in patients with chronic coronary artery disease. Journal Of Nuclear Cardiology 2003, 10: 267-274. PMID: 12794625, DOI: 10.1016/s1071-3581(02)43235-7.Peer-Reviewed Original ResearchConceptsMyocardial perfusion imagingChronic coronary artery diseaseLeft ventricular dysfunctionVentricular dysfunctionCoronary artery diseaseReversible perfusion defectsPerfusion defectsArtery diseaseVentricular functionMyocardial perfusionNew regional wall motion abnormalitiesSestamibi single-photon emissionPharmacologic stress myocardial perfusion imagingStress myocardial perfusion imagingGlobal left ventricular dysfunctionRegional wall motion abnormalitiesResultsTwenty-eight patientsLeft ventricular functionWall motion abnormalitiesTomography (SPECT) MPIMyocardial perfusion defectsRegional wall motionCircumferential profile analysisSingle photon emissionSimultaneous assessment
1998
Cerebral cortical hyperactivation in response to mental stress in patients with coronary artery disease
Soufer R, Bremner J, Arrighi J, Cohen I, Zaret B, Burg M, Goldman-Rakic P. Cerebral cortical hyperactivation in response to mental stress in patients with coronary artery disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 6454-6459. PMID: 9600987, PMCID: PMC27794, DOI: 10.1073/pnas.95.11.6454.Peer-Reviewed Original ResearchMeSH KeywordsAdultCerebral CortexCoronary DiseaseEchocardiographyHeart RateHumansMagnetic Resonance ImagingMaleStress, PsychologicalConceptsCoronary artery diseaseVisual association cortexSuperior frontal gyrusRight visual association cortexCAD patientsHealthy subjectsPositron emission tomographyMental stressAssociation cortexFrontal gyrusArtery diseaseMyocardial ischemiaAnterior cingulateCentral nervous system effectsCAD patient groupCerebral cortical responsePainless myocardial ischemiaNervous system effectsLeft parietal cortexInferior parietal lobuleMiddle temporal gyrusPatient groupSerial subtraction taskRight thalamusInferior frontal gyrus
1995
Left ventricular diastolic function: Physiology, methods of assessment, and clinical significance
Arrighi J, Soufer R. Left ventricular diastolic function: Physiology, methods of assessment, and clinical significance. Journal Of Nuclear Cardiology 1995, 2: 525-543. PMID: 9420835, DOI: 10.1016/s1071-3581(05)80045-5.Peer-Reviewed Original ResearchConceptsDiastolic functionVentricular fillingHeart failureElevated pulmonary venous pressureNormal systolic ventricular functionSystolic ventricular functionNormal systolic functionCongestive heart failurePulmonary venous pressureCoronary artery diseaseCalcium channel blockersEarly ventricular fillingHealthy elderly subjectsMitral valve closureBeta blockersSystolic functionArtery diseaseCardiac catheterizationSuch patientsValvular diseaseVenous pressureVentricular functionOptimal therapyRadionuclide angiographyMyocardial compliance
1992
The Radionuclide Assessment of Left Ventricular Diastolic Filling: Methodology and Clinical Significance
SOUFER R, DEY H. The Radionuclide Assessment of Left Ventricular Diastolic Filling: Methodology and Clinical Significance. Echocardiography 1992, 9: 339-348. PMID: 10149890, DOI: 10.1111/j.1540-8175.1992.tb00475.x.Peer-Reviewed Original ResearchConceptsDiastolic fillingLeft ventricular diastolic fillingDiastolic heart failureVentricular diastolic fillingHypertensive heart diseaseCoronary artery diseaseAppropriate clinical contextArtery diseaseHeart failureDiastolic performanceHeart diseasePathophysiological presentationHypertrophic cardiomyopathyClinical significanceNoninvasive indexRadionuclide assessmentClinical settingRadionuclide methodsClinical contextDiseaseCardiomyopathyRadionuclide measurements
1990
Usefulness of verapamil for congestive heart failure associated with abnormal left ventricular diastolic filling and normal left ventricular systolic performance
Setaro J, Zaret B, Schulman D, Black H, Soufer R. Usefulness of verapamil for congestive heart failure associated with abnormal left ventricular diastolic filling and normal left ventricular systolic performance. The American Journal Of Cardiology 1990, 66: 981-986. PMID: 2220622, DOI: 10.1016/0002-9149(90)90937-v.Peer-Reviewed Original ResearchConceptsCongestive heart failureNormal left ventricular systolic performanceLeft ventricular diastolic fillingLeft ventricular systolic performanceVentricular diastolic fillingVentricular systolic performanceDiastolic fillingBlood pressureHeart failureSystolic performanceAbnormal left ventricular diastolic fillingThallium-201 stress scintigraphyAbnormal diastolic fillingEDV/sHeart failure scoreSignificant valvular diseaseMean ejection fractionDiastolic blood pressureSystolic blood pressureLeft ventricular functionPeak filling rateOral verapamilExercise capacityPlacebo valuesSystolic function