2001
Reproducibility of in vivo brain measures of 5-HT2A receptors with PET and [18F]deuteroaltanserin
Soares J, van Dyck C, Tan P, Zoghbi S, Garg P, Soufer R, Baldwin R, Fujita M, Staley J, Fu X, Amici L, Seibyl J, Innis R. Reproducibility of in vivo brain measures of 5-HT2A receptors with PET and [18F]deuteroaltanserin. Psychiatry Research 2001, 106: 81-93. PMID: 11306248, DOI: 10.1016/s0925-4927(01)00071-3.Peer-Reviewed Original ResearchConceptsTest/retest reproducibilityPositron emission tomographyCortical brain areasIntra-class correlation coefficientRetest reproducibilityBrain areasBrain measuresHealthy human subjectsMean intra-class correlation coefficientOutcome measuresConstant infusionParent tracerBlood measurementsEmission tomographyNeuropsychiatric disordersPET measuresReceptorsHuman subjectsPET acquisitionMean intraEquilibrium imagingImaging methodInfusionBolusRT
1999
A complete remote-control system for reliable preparation of [18F]altanserin
Tan P, Baldwin R, Soufer R, Garg P, Charney D, Innis R. A complete remote-control system for reliable preparation of [18F]altanserin. Applied Radiation And Isotopes 1999, 50: 923-927. PMID: 10214711, DOI: 10.1016/s0969-8043(98)00150-x.Peer-Reviewed Original Research
1997
Radiosynthesis and PET imaging of [N-methyl-11C]LY257327 as a tracer for 5-HT transporters
Zea-Ponce Y, Baldwin R, Stratton M, Al-Tikriti M, Soufer R, Schaus J, Innis R. Radiosynthesis and PET imaging of [N-methyl-11C]LY257327 as a tracer for 5-HT transporters. Nuclear Medicine And Biology 1997, 24: 251-254. PMID: 9228659, DOI: 10.1016/s0969-8051(97)00062-0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCarrier ProteinsChromatography, High Pressure LiquidCitalopramFemaleIsotope LabelingMaleMembrane GlycoproteinsMembrane Transport ProteinsNerve Tissue ProteinsOvariectomyPapioParoxetinePiperazinesRadiopharmaceuticalsRatsRats, Sprague-DawleySelective Serotonin Reuptake InhibitorsSerotonin Plasma Membrane Transport ProteinsSpectrophotometry, UltravioletTetrahydronaphthalenesTomography, Emission-ComputedConceptsSelective serotonin reuptake inhibitor citalopramSerotonin reuptake inhibitor citalopramReuptake inhibitor citalopramHigh brain uptakeSame brain regionsPositron emission tomographySerotonergic areasBrain uptakeMin postinjectionNontarget ratioUseful agentBrain regionsEmission tomographyN-methylMCi/mumolPET imagingNonspecific uptakeVivo studiesPartial inhibitionRadiochemical purityRadioactivity concentrationThalamusStriatumSerotoninCitalopram