2007
The heart-brain interaction during emotionally provoked myocardial ischemia: implications of cortical hyperactivation in CAD and gender interactions.
Soufer R, Burg MM. The heart-brain interaction during emotionally provoked myocardial ischemia: implications of cortical hyperactivation in CAD and gender interactions. Cleveland Clinic Journal Of Medicine 2007, 74 Suppl 1: s59-62. PMID: 17455547, DOI: 10.3949/ccjm.74.suppl_1.s59.Peer-Reviewed Original ResearchConceptsMental stress-induced ischemiaStress-induced ischemiaMental stressMyocardial ischemiaAcute coronary syndromeRecurrent cardiac eventsSilent myocardial ischemiaRisk stratification algorithmLong-term outcomesTreatment of patientsHeart-brain interactionsDifferential pathophysiologyCoronary syndromeCardiac eventsRisk stratificationPoor prognosisTransient ischemiaVulnerable patientsStratification algorithmCortical hyperactivationEarly deathIschemiaDiagnostic testingClinical settingClinical goals
1998
Cerebral cortical hyperactivation in response to mental stress in patients with coronary artery disease
Soufer R, Bremner J, Arrighi J, Cohen I, Zaret B, Burg M, Goldman-Rakic P. Cerebral cortical hyperactivation in response to mental stress in patients with coronary artery disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 6454-6459. PMID: 9600987, PMCID: PMC27794, DOI: 10.1073/pnas.95.11.6454.Peer-Reviewed Original ResearchMeSH KeywordsAdultCerebral CortexCoronary DiseaseEchocardiographyHeart RateHumansMagnetic Resonance ImagingMaleStress, PsychologicalConceptsCoronary artery diseaseVisual association cortexSuperior frontal gyrusRight visual association cortexCAD patientsHealthy subjectsPositron emission tomographyMental stressAssociation cortexFrontal gyrusArtery diseaseMyocardial ischemiaAnterior cingulateCentral nervous system effectsCAD patient groupCerebral cortical responsePainless myocardial ischemiaNervous system effectsLeft parietal cortexInferior parietal lobuleMiddle temporal gyrusPatient groupSerial subtraction taskRight thalamusInferior frontal gyrus