2001
Reproducibility of in vivo brain measures of 5-HT2A receptors with PET and [18F]deuteroaltanserin
Soares J, van Dyck C, Tan P, Zoghbi S, Garg P, Soufer R, Baldwin R, Fujita M, Staley J, Fu X, Amici L, Seibyl J, Innis R. Reproducibility of in vivo brain measures of 5-HT2A receptors with PET and [18F]deuteroaltanserin. Psychiatry Research 2001, 106: 81-93. PMID: 11306248, DOI: 10.1016/s0925-4927(01)00071-3.Peer-Reviewed Original ResearchConceptsTest/retest reproducibilityPositron emission tomographyCortical brain areasIntra-class correlation coefficientRetest reproducibilityBrain areasBrain measuresHealthy human subjectsMean intra-class correlation coefficientOutcome measuresConstant infusionParent tracerBlood measurementsEmission tomographyNeuropsychiatric disordersPET measuresReceptorsHuman subjectsPET acquisitionMean intraEquilibrium imagingImaging methodInfusionBolusRTComparison of [18F]altanserin and [18F]deuteroaltanserin for PET imaging of serotonin2A receptors in baboon brain: pharmacological studies
Staley J, Van Dyck C, Tan P, Tikriti M, Ramsby Q, Klump H, Ng C, Garg P, Soufer R, Baldwin R, Innis R. Comparison of [18F]altanserin and [18F]deuteroaltanserin for PET imaging of serotonin2A receptors in baboon brain: pharmacological studies. Nuclear Medicine And Biology 2001, 28: 271-279. PMID: 11323237, DOI: 10.1016/s0969-8051(00)00212-2.Peer-Reviewed Original ResearchConceptsReceptor antagonist SR 46349BSerotonin2A receptorsSR 46349BReceptor radiotracerPharmacological specificityTime-activity curvesConstant infusionBaboon brainCortical activityDistribution volumePharmacological studiesPET imagingRadiotracerBrainReceptorsBaboonsPET imagesRegional distributionFenfluramineInfusionBolus
2000
PET quantification of 5-HT2A receptors in the human brain: a constant infusion paradigm with [18F]altanserin.
van Dyck CH, Tan PZ, Baldwin RM, Amici LA, Garg PK, Ng CK, Soufer R, Charney DS, Innis RB. PET quantification of 5-HT2A receptors in the human brain: a constant infusion paradigm with [18F]altanserin. Journal Of Nuclear Medicine 2000, 41: 234-41. PMID: 10688105.Peer-Reviewed Original ResearchConceptsConstant infusion paradigmInfusion paradigmFrontal cortexAnterior cingulateVenous blood samplingPathophysiology of schizophreniaLipophilic radiometabolitesIntravenous administrationInfusion periodHealthy volunteersPET acquisitionReceptor densityBlood samplingTime-activity curvesConstant infusionLinear regression analysisH onwardMetabolite concentrationsBrain activityRegression analysisCingulateCortexHuman brainReceptorsPET quantification
1999
Kinetic modeling of benzodiazepine receptor binding with PET and high specific activity [11C]Iomazenil in healthy human subjects
Bremner J, Horti A, Staib L, Zea‐Ponce Y, Soufer R, Charney D, Baldwin R. Kinetic modeling of benzodiazepine receptor binding with PET and high specific activity [11C]Iomazenil in healthy human subjects. Synapse 1999, 35: 68-77. PMID: 10579810, DOI: 10.1002/(sici)1098-2396(200001)35:1<68::aid-syn9>3.0.co;2-h.Peer-Reviewed Original ResearchConceptsBenzodiazepine receptor bindingHealthy human subjectsReceptor bindingBenzodiazepine receptorsHuman subjectsBenzodiazepine receptor antagonistCompartment modelReceptor antagonistMultiple time pointsBolus injectionArterial samplesTime-activity curvesSPECT radioligandBrain tissueBrain tissue compartmentsPET imagingTime pointsPrior reportsRadioligandParent compoundTissue compartmentsRadioligand concentrationHigh specific activityWiley-LissReceptorsQuantitation of benzodiazepine receptor binding with PET [11C]iomazenil and SPECT [123I]iomazenil: preliminary results of a direct comparison in healthy human subjects
Bremner J, Baldwin R, Horti A, Staib L, Ng C, Tan P, Zea-Ponce Y, Zoghbi S, Seibyl J, Soufer R, Charney D, Innis R. Quantitation of benzodiazepine receptor binding with PET [11C]iomazenil and SPECT [123I]iomazenil: preliminary results of a direct comparison in healthy human subjects. Psychiatry Research 1999, 91: 79-91. PMID: 10515463, DOI: 10.1016/s0925-4927(99)00015-3.Peer-Reviewed Original ResearchConceptsPositron emission tomographyBenzodiazepine receptorsArterial blood samplesBenzodiazepine receptor bindingHealthy human subjectsHuman subjectsNeuroreceptor bindingSingle photon emissionSingle bolusOccipital cortexBlood samplesTemporal cortexEmission tomographyBrain compartmentsDynamic positron emission tomographyReceptor bindingSPECTSame human subjectsPhoton emissionCortexHuman brainRadioligandPreliminary findingsBrainReceptors