2020
The Foundational Role of Cardiovascular Imaging in the Characterization of Mental Stress–Induced Myocardial Ischemia in Patients with Coronary Artery Disease
Meadows JL, Shah S, Burg MM, Pfau S, Soufer R. The Foundational Role of Cardiovascular Imaging in the Characterization of Mental Stress–Induced Myocardial Ischemia in Patients with Coronary Artery Disease. Current Cardiology Reports 2020, 22: 162. PMID: 33037938, DOI: 10.1007/s11886-020-01407-w.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCoronary artery diseaseArtery diseaseMyocardial ischemiaMental Stress–Induced Myocardial IschemiaNon-obstructive coronary artery diseaseStable coronary artery diseaseHalf of patientsEpicardial coronary stenosisMental stress testingMyocardial oxygen demandUnderstanding of pathophysiologyCoronary macroAnginal symptomsCardiac eventsAdverse prognosisEarly mortalityIschemic phenomenaCoronary perfusionCoronary stenosisCoronary microvasculatureInvasive studiesClinical careMyocardial perfusionStress-mediated changesCardiac responseCardiovascular Imaging of Biology and Emotion
Meadows JL, Shah S, Burg MM, Pfau S, Soufer R. Cardiovascular Imaging of Biology and Emotion. Circulation Cardiovascular Imaging 2020, 13: e011054. PMID: 32762255, PMCID: PMC9261020, DOI: 10.1161/circimaging.120.011054.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMental stressEpicardial coronary artery diseaseCoronary artery diseaseExercise-induced changesMicrovascular dysfunctionArtery diseaseObstructive diseaseClinical manifestationsVascular responsesCentral activationCardiovascular healthPathophysiologic changesCardiovascular responsesMyocardial ischemiaPeripheral vasculatureTreatment targetsVascular pathophysiologyPsychosocial determinantsCardiovascular imagingPsychosocial experiencesImplementation studyMS testingTriggers activationCardiovascular biologyDisease
2016
Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1&bgr; Production
Ceneri N, Zhao L, Young BD, Healy A, Coskun S, Vasavada H, Yarovinsky TO, Ike K, Pardi R, Qin L, Qin L, Tellides G, Hirschi K, Meadows J, Soufer R, Chun HJ, Sadeghi M, Bender JR, Morrison AR. Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1&bgr; Production. Arteriosclerosis Thrombosis And Vascular Biology 2016, 37: 328-340. PMID: 27834690, PMCID: PMC5269510, DOI: 10.1161/atvbaha.116.308507.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortaAortic DiseasesApolipoproteins EAtherosclerosisCells, CulturedCoronary Artery DiseaseCoronary VesselsFemaleGenetic Predisposition to DiseaseHumansInflammation MediatorsInterleukin 1 Receptor Antagonist ProteinInterleukin-1betaMacrophagesMaleMice, Inbred C57BLMice, KnockoutMuscle, Smooth, VascularMyocytes, Smooth MuscleNeuropeptidesPhenotypePlaque, AtheroscleroticPrognosisRac GTP-Binding ProteinsRac1 GTP-Binding ProteinSignal TransductionTransfectionUp-RegulationVascular CalcificationConceptsCoronary calcium burdenIL-1β expressionCalcium burdenSerum IL-1β levelsElevated IL-1βIL-1β levelsCoronary artery diseaseInterleukin-1β expressionCalcified coronary arteryCardiovascular deathCardiovascular eventsArtery diseaseIndependent predictorsClinical outcomesVascular calcificationCoronary arteryIL-1βPlaque calciumAtherosclerotic calcificationExperimental atherogenesisInflammatory regulatorsMacrophage interleukinAtherosclerotic plaquesTherapeutic targetProgressive calcificationBody Mass Index and Risk for Mental Stress-Induced Ischemia in Coronary Artery Disease
Soufer R, Fernandez AB, Meadows J, Collins D, Burg MM. Body Mass Index and Risk for Mental Stress-Induced Ischemia in Coronary Artery Disease. Molecular Medicine 2016, 22: 286-291. PMID: 27261777, PMCID: PMC5023512, DOI: 10.2119/molmed.2016.00128.Peer-Reviewed Original ResearchBody mass indexHigher body mass indexMental stressMass indexChronic inflammationAutonomic dysregulationMyocardial ischemiaTraditional coronary artery disease risk factorsConfidence intervalsCoronary artery disease risk factorsMean body mass indexGreater body mass indexLaboratory mental stressHistory of hypertensionIndependent risk markerDisease risk factorsProspective interventional studyCoronary artery diseaseMultivariate logistic regressionMyocardial blood flowSingle photon emissionStress–Induced IschemiaCAD mortalityElevated markersStable CAD
2013
The Role of Cardiovascular Nuclear Imaging in Clinical Consultation
Meadows J, Soufer R. The Role of Cardiovascular Nuclear Imaging in Clinical Consultation. 2013, 159-180. DOI: 10.1007/978-1-4471-4441-0_13.Peer-Reviewed Original ResearchCoronary artery diseaseArtery diseaseNuclear cardiology techniquesCardiovascular prognosisRevascularization strategyRisk stratificationCardiology testsMyocardial perfusionPerfusion imagingClinical consultationPhysiologic principlesConsultant evaluationCardiovascular Nuclear ImagingNuclear imagingDiseaseImagingPatientsPrognosisPerfusionDiagnosis
2011
Autonomic Contribution to Endothelin-1 Increase during Laboratory Anger-Recall Stress in Patients with Coronary Artery Disease
Burg MM, Soufer A, Lampert R, Collins D, Soufer R. Autonomic Contribution to Endothelin-1 Increase during Laboratory Anger-Recall Stress in Patients with Coronary Artery Disease. Molecular Medicine 2011, 17: 495-501. PMID: 21267513, PMCID: PMC3105151, DOI: 10.2119/molmed.2010.00083.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseEndothelin-1Parasympathetic activityArtery diseaseAutonomic contributionsChronic stable coronary artery diseaseStable coronary artery diseaseCholinergic antiinflammatory pathwayLaboratory stressCoronary plaque ruptureEndothelin-1 increaseSignificant odds ratioEndothelial cell functionCardiac eventsEndothelial dysfunctionIndwelling catheterAutonomic factorsSympathetic activityAntiinflammatory pathwayAutonomic influencesAutonomic toneOdds ratioPlaque ruptureParasympathetic withdrawalHemodynamic monitor
2010
Depression Predicts Elevated Endothelin-1 in Patients With Coronary Artery Disease
Burg MM, Martens EJ, Collins D, Soufer R. Depression Predicts Elevated Endothelin-1 in Patients With Coronary Artery Disease. Psychosomatic Medicine 2010, 73: 2-6. PMID: 20947777, PMCID: PMC3016462, DOI: 10.1097/psy.0b013e3181fdfb25.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseEndothelin-1Beck Depression InventoryBDI scoresLogistic regression modelsArtery diseaseLog-transformed continuous variableRisk thresholdElevated endothelin-1ET-1 elevationET-1 levelsEvent-free survivalMorning blood samplesWorse depression symptomsDepression symptom severityEarly morbidityRegression modelsPoor survivalPlaque ruptureAdjusted modelBlood samplesDepressive symptomsDepression severityDepression symptomsDepression InventoryTendency to Angry Rumination Predicts Stress-Provoked Endothelin-1 Increase in Patients With Coronary Artery Disease
Fernandez AB, Soufer R, Collins D, Soufer A, Ranjbaran H, Burg MM. Tendency to Angry Rumination Predicts Stress-Provoked Endothelin-1 Increase in Patients With Coronary Artery Disease. Psychosomatic Medicine 2010, 72: 348-353. PMID: 20368479, PMCID: PMC2872076, DOI: 10.1097/psy.0b013e3181d71982.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseET-1 increaseET-1Chronic stable coronary heart diseaseStable coronary heart diseaseMultivariate logistic regression modelET-1 elevationAcute coronary syndromeHistory of diabetesRate-pressure productCoronary artery diseaseEndothelin-1 increaseLogistic regression modelsCoronary syndromeArtery diseaseBeta blockersPotential confoundersPressure productHeart diseasePlaque ruptureBlood samplesPatientsAngry ruminationNitric oxideStress protocol
2009
Heart-brain interactions in mental stress-induced myocardial ischemia
Soufer R, Jain H, Yoon AJ. Heart-brain interactions in mental stress-induced myocardial ischemia. Current Cardiology Reports 2009, 11: 133-140. PMID: 19236829, PMCID: PMC3726062, DOI: 10.1007/s11886-009-0020-1.Peer-Reviewed Original ResearchConceptsMental stress ischemiaStress ischemiaMyocardial ischemiaMental stress-induced myocardial ischemiaStress-induced myocardial ischemiaCoronary artery diseaseCentral nervous systemHeart-brain interactionsArtery diseasePoor prognosisAutonomic balancePathophysiologic underpinningsTreatment strategiesNervous systemIschemiaPsychosocial stressBiobehavioral aspectsBiobehavioral modelBiologic consequencesSensory inputBiologic processesBrainEmotional provocationPatientsPrognosis
2008
Noninvasive Detection of Risk for Emotion Provoked Myocardial Ischemia
Burg MM, Graeber B, Vashist A, Collins D, Earley C, Liu J, Lampert R, Soufer R. Noninvasive Detection of Risk for Emotion Provoked Myocardial Ischemia. Psychosomatic Medicine 2008, 71: 14-20. PMID: 18941131, PMCID: PMC2739989, DOI: 10.1097/psy.0b013e318187c035.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngerAngiotensin-Converting Enzyme InhibitorsBlood PressureCoronary DiseaseEpinephrineFemaleHeart RateHumansImagery, PsychotherapyMaleManometryMiddle AgedMyocardial IschemiaNorepinephrinePlethysmographyPredictive Value of TestsPulsatile FlowRiskSensitivity and SpecificityStress, PsychologicalTomography, Emission-Computed, Single-PhotonVascular ResistanceConceptsPeripheral arterial tonometryCoronary artery diseasePAT ratioMyocardial ischemiaMajor adverse cardiac eventsStable coronary artery diseaseLower PAT ratioMental stress ischemiaAdverse cardiac eventsNew perfusion defectsCT myocardial perfusionSensitivity/specificityStress ischemiaArterial tonometryCardiac eventsArtery diseaseBlood pressureACE inhibitionPerfusion defectsHeart rateMyocardial perfusionPatientsEnzyme inhibitorsClinical settingIschemia
2006
C-Reactive Protein and Vulnerability to Mental Stress-Induced Myocardial Ischemia
Shah R, Burg MM, Vashist A, Collins D, Liu J, Jadbabaie F, Graeber B, Earley C, Lampert R, Soufer R. C-Reactive Protein and Vulnerability to Mental Stress-Induced Myocardial Ischemia. Molecular Medicine 2006, 12: 269-274. PMID: 17380191, PMCID: PMC1829194, DOI: 10.2119/2006-00077.shah.Peer-Reviewed Original ResearchConceptsC-reactive proteinCoronary artery diseaseMyocardial perfusion imagingTransthoracic echocardiographyCRP levelsMental stressRisk markersMyocardial ischemiaLevels of CRPNew regional wall motion abnormalitiesAssociation of CRPRelationship of CRPSimultaneous single-photon emissionStable coronary artery diseaseUnivariate logistic regression analysisRegional wall motion abnormalitiesTetrofosmin myocardial perfusion imagingLaboratory mental stressRisk of MSISerum CRP levelsHistory of diabetesSubsequent clinical eventsNew perfusion defectsWall motion abnormalitiesLogistic regression analysis
2004
Differential impact of parasympathetic withdrawal to mental stress ischemia as assessed by noninvasive evaluation of myocardial perfusion and/or function
Vashist A, Arrighi J, Lampert R, Burg M, Soufer R. Differential impact of parasympathetic withdrawal to mental stress ischemia as assessed by noninvasive evaluation of myocardial perfusion and/or function. Journal Of Nuclear Cardiology 2004, 11: s21. DOI: 10.1016/j.nuclcard.2004.06.068.Peer-Reviewed Original ResearchChronic coronary artery diseaseRegional LV dysfunctionMyocardial ischemiaParasympathetic withdrawalLV dysfunctionChronic chronic coronary artery diseaseMental stress ischemiaRate-pressure productCoronary artery diseaseGreater parasympathetic withdrawalHigh-frequency powerStress ischemiaArtery diseaseNon-invasive imagingMPI defectsSympathovagal balanceIndividual patientsSPECT-MPIIschemiaMyocardial perfusionNoninvasive evaluationPatientsMental arithmetic taskAutonomic responsesSPECT defects
2003
Simultaneous assessment of myocardial perfusion and function during mental stress in patients with chronic coronary artery disease
Arrighi JA, Burg M, Cohen IS, Soufer R. Simultaneous assessment of myocardial perfusion and function during mental stress in patients with chronic coronary artery disease. Journal Of Nuclear Cardiology 2003, 10: 267-274. PMID: 12794625, DOI: 10.1016/s1071-3581(02)43235-7.Peer-Reviewed Original ResearchConceptsMyocardial perfusion imagingChronic coronary artery diseaseLeft ventricular dysfunctionVentricular dysfunctionCoronary artery diseaseReversible perfusion defectsPerfusion defectsArtery diseaseVentricular functionMyocardial perfusionNew regional wall motion abnormalitiesSestamibi single-photon emissionPharmacologic stress myocardial perfusion imagingStress myocardial perfusion imagingGlobal left ventricular dysfunctionRegional wall motion abnormalitiesResultsTwenty-eight patientsLeft ventricular functionWall motion abnormalitiesTomography (SPECT) MPIMyocardial perfusion defectsRegional wall motionCircumferential profile analysisSingle photon emissionSimultaneous assessmentPresurgical Depression Predicts Medical Morbidity 6 Months After Coronary Artery Bypass Graft Surgery
Burg MM, Benedetto MC, Rosenberg R, Soufer R. Presurgical Depression Predicts Medical Morbidity 6 Months After Coronary Artery Bypass Graft Surgery. Psychosomatic Medicine 2003, 65: 111-118. PMID: 12554822, DOI: 10.1097/01.psy.0000038940.33335.09.Peer-Reviewed Original ResearchConceptsCoronary artery bypass graft surgeryArtery bypass graft surgeryBypass graft surgeryPresurgical depressionBeck Depression InventoryGraft surgeryDepression IndexMedical outcomesDepression InventoryShort-term medical outcomesPsychosocial risk indexCoronary artery diseasePoor medical prognosisImpact of depressionPsychosocial risk factorsOutcomes of interestQuality of lifeImportant independent contributorCardiac hospitalizationArtery diseaseSurgical painPsychosocial morbidityMedical recordsRisk factorsStudy population
2001
7.44 Simultaneous assessment of myocardial perfusion and function during mental stress in patients with chronic coronary artery disease
Arrighi J, Burg M, Cohen I, Soufer R. 7.44 Simultaneous assessment of myocardial perfusion and function during mental stress in patients with chronic coronary artery disease. Journal Of Nuclear Cardiology 2001, 8: s51. DOI: 10.1016/s1071-3581(01)80621-8.Peer-Reviewed Original Research
2000
Myocardial blood-flow response during mental stress in patients with coronary artery disease
Arrighi J, Burg M, Cohen I, Kao A, Pfau S, Caulin-Glaser T, Zaret B, Soufer R. Myocardial blood-flow response during mental stress in patients with coronary artery disease. The Lancet 2000, 356: 310-311. PMID: 11071190, DOI: 10.1016/s0140-6736(00)02510-1.Peer-Reviewed Original Research
1998
Cerebral cortical hyperactivation in response to mental stress in patients with coronary artery disease
Soufer R, Bremner J, Arrighi J, Cohen I, Zaret B, Burg M, Goldman-Rakic P. Cerebral cortical hyperactivation in response to mental stress in patients with coronary artery disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 6454-6459. PMID: 9600987, PMCID: PMC27794, DOI: 10.1073/pnas.95.11.6454.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseVisual association cortexSuperior frontal gyrusRight visual association cortexCAD patientsHealthy subjectsPositron emission tomographyMental stressAssociation cortexFrontal gyrusArtery diseaseMyocardial ischemiaAnterior cingulateCentral nervous system effectsCAD patient groupCerebral cortical responsePainless myocardial ischemiaNervous system effectsLeft parietal cortexInferior parietal lobuleMiddle temporal gyrusPatient groupSerial subtraction taskRight thalamusInferior frontal gyrusEffects of Mental Stress on Left Ventricular and Peripheral Vascular Performance in Patients With Coronary Artery Disease
Jain D, Shaker M, Burg M, Wackers F, Soufer R, Zaret B. Effects of Mental Stress on Left Ventricular and Peripheral Vascular Performance in Patients With Coronary Artery Disease. Journal Of The American College Of Cardiology 1998, 31: 1314-1322. PMID: 9581726, DOI: 10.1016/s0735-1097(98)00092-8.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionPeripheral vascular resistanceCoronary artery diseaseRate-pressure productStress-induced fallSystolic blood pressureArtery diseaseBlood pressureCardiac outputHeart rateMental stressGroup IHemodynamic variablesAnger recallGroup IIMental stressorsEnd-systolic ventricular elastanceMental stress-induced changesSemisupine bicycle exerciseGroup II patientsComparable increaseDiastolic blood pressureVentricular ejection fractionExercise-induced changesVascular resistance
1997
Effect of left ventricular function on the assessment of myocardial viability by technectium-99m sestamibi and correlation with positron emission tomography in patients with healed myocardial infarcts or stable angina pectoris, or both
Arrighi J, Ng C, Dey H, Wackers F, Soufer R. Effect of left ventricular function on the assessment of myocardial viability by technectium-99m sestamibi and correlation with positron emission tomography in patients with healed myocardial infarcts or stable angina pectoris, or both. The American Journal Of Cardiology 1997, 80: 1007-1013. PMID: 9352969, DOI: 10.1016/s0002-9149(97)00594-8.Peer-Reviewed Original ResearchConceptsCoronary artery diseasePositron emission tomographyLV dysfunctionArtery diseaseGroup 2Myocardial viabilityGroup 1Ejection fractionModerate coronary artery diseaseEmission tomographyModerate LV dysfunctionSevere LV dysfunctionStable angina pectorisLV ejection fractionGlobal LV dysfunctionAccuracy of technetiumSingle photon emissionSemiquantitative SPECTVentricular dysfunctionViability detectionAngina pectorisVentricular functionReduced perfusionSestamibi SPECTMyocardial infarct
1995
Left ventricular diastolic function: Physiology, methods of assessment, and clinical significance
Arrighi J, Soufer R. Left ventricular diastolic function: Physiology, methods of assessment, and clinical significance. Journal Of Nuclear Cardiology 1995, 2: 525-543. PMID: 9420835, DOI: 10.1016/s1071-3581(05)80045-5.Peer-Reviewed Original ResearchConceptsDiastolic functionVentricular fillingHeart failureElevated pulmonary venous pressureNormal systolic ventricular functionSystolic ventricular functionNormal systolic functionCongestive heart failurePulmonary venous pressureCoronary artery diseaseCalcium channel blockersEarly ventricular fillingHealthy elderly subjectsMitral valve closureBeta blockersSystolic functionArtery diseaseCardiac catheterizationSuch patientsValvular diseaseVenous pressureVentricular functionOptimal therapyRadionuclide angiographyMyocardial compliance