2023
Patient-, Clinician-, and Institution-level Variation in Inotrope Use for Cardiac Surgery: A Multicenter Observational Analysis
Mathis M, Janda A, Kheterpal S, Schonberger R, Pagani F, Engoren M, Mentz G, Shook D, Muehlschlegel J, Cassidy R, Clark D, Colquhoun D, Freundlich R, Jewell E. Patient-, Clinician-, and Institution-level Variation in Inotrope Use for Cardiac Surgery: A Multicenter Observational Analysis. Anesthesiology 2023, 139: 122-141. PMID: 37094103, PMCID: PMC10524016, DOI: 10.1097/aln.0000000000004593.Peer-Reviewed Original ResearchConceptsInotrope useCardiac surgeryHome medicationsAdjusted median odds ratioPulmonary circulation disordersAdult cardiac surgeryMechanical circulatory supportMedian odds ratioMedical school affiliationHome inotropesInotrope infusionInotrope therapyInotropic therapyCardiopulmonary bypassHeart failureMulticenter cohortPrimary outcomeCirculatory supportBlack raceCirculation disordersOdds ratioCommunity hospitalObservational studySame patientPatients
2022
Oxygen administration during surgery and postoperative organ injury: observational cohort study
McIlroy D, Shotwell M, Lopez M, Vaughn M, Olsen J, Hennessy C, Wanderer J, Semler M, Rice T, Kheterpal S, Billings F, Group M, Cuff G, Freundlich R, Kurz A, Naik B, Mathis M, Schonberger R. Oxygen administration during surgery and postoperative organ injury: observational cohort study. The BMJ 2022, 379: e070941. PMID: 36450405, PMCID: PMC9710248, DOI: 10.1136/bmj-2022-070941.Peer-Reviewed Original ResearchConceptsAcute kidney injuryObservational cohort studyLung injuryKidney injuryMyocardial injuryOxygen administrationGreater oddsCohort studyMedian age 59 yearsHospital discharge diagnosis codesGlobal Outcomes criteriaAge 59 yearsHours of surgeryDischarge diagnosis codesPotential confounding variablesHemoglobin oxygen saturationPostoperative kidneyPrimary endpointAdult patientsMedian durationOrgan injurySerum troponinEndotracheal intubationGeneral anesthesiaKidney disease
2021
Trends in personal protective equipment use by clinicians performing airway procedures for patients with coronavirus disease 2019 in the USA from the intubateCOVID registry
Gaulton T, Neuman M, Investigators I, Gaulton T, Neuman M, Lane-Fall M, Gaskins L, Dattilo J, El-Boghdadly K, Wong D, Ahmad I, Johnstone C, Gutstein H, Muehlschlegel J, Hua M, Fonseca L, Mitrev L, Low Y, Gupta D, Ayad S, Volio A, Salih A, Kim D, Nutcharoen A, Skolaris A, Sherman M, Giska M, Nowak K, Chhina A, Guruswamy J, Penning D, Majewski M, Nagrebetsky A, Houle T, Aziz M, Freed J, Lien C, Mihm F, Desai P, Fahy B, Davies L, Adair K, Gunnett A, Mhyre J, Sharawi N, Applegate R, Brzenski A, Lin M, Olmos A, Chen C, Gropper M, Shochat G, Hoefnagel A, Ranganath Y, Sibenellar Z, Colquhoun D, Cloyd B, Healy D, Mathis M, Schechtman S, Steadman J, Stuart A, Bott S, Gerety L, Fisher J, Friend A, Breidenstein M, Domino K, Cervantes V, Joffe A, Dutton R, Shanahan J, Leissner K, Jaffe J, Strathman A, Khanna A, Segal B, Harris L, Fowler J, Johnson K, Hill S, Murrell M, Panzica P, Mittnacht A, Abramowicz E, Wecksell M, Schonberger R, Li J, Michel S, Treggiari M, Berstein S, Dashevksy M. Trends in personal protective equipment use by clinicians performing airway procedures for patients with coronavirus disease 2019 in the USA from the intubateCOVID registry. British Journal Of Anaesthesia 2021, 126: e184-e186. PMID: 33612248, PMCID: PMC8052559, DOI: 10.1016/j.bja.2021.01.019.Peer-Reviewed Original Research
2018
Quantification of Postmembrane Gaseous Microembolization During Venoarterial Extracorporeal Membrane Oxygenation
Jiao Y, Gipson KE, Bonde P, Mangi A, Hagberg R, Rosinski DJ, Gross JB, Schonberger RB. Quantification of Postmembrane Gaseous Microembolization During Venoarterial Extracorporeal Membrane Oxygenation. ASAIO Journal 2018, 64: 31-37. PMID: 28557862, DOI: 10.1097/mat.0000000000000598.Peer-Reviewed Original ResearchConceptsVenoarterial extracorporeal membrane oxygenationVA-ECMO patientsExtracorporeal membrane oxygenationGaseous microemboliVA-ECMOECMO patientsMembrane oxygenationCardiopulmonary bypassAdult VA-ECMO patientsExtracorporeal membrane oxygenation circuitEnd-organ dysfunctionInstitutional review board approvalRoutine patient careMembrane oxygenation circuitPatient care eventsPatient care activitiesReview board approvalOrgan dysfunctionEmbolic rateClinical eventsObservational studyIntravenous injectionEnd organsGME volumeBoard approval
2017
Postcardiotomy Venoarterial Extracorporeal Membrane Oxygenation (VA ECMO) in Adult Patients – Many Questions, Few Answers, and Hard Choices
Bardia A, Schonberger RB. Postcardiotomy Venoarterial Extracorporeal Membrane Oxygenation (VA ECMO) in Adult Patients – Many Questions, Few Answers, and Hard Choices. Journal Of Cardiothoracic And Vascular Anesthesia 2017, 32: 1183-1184. PMID: 29276089, DOI: 10.1053/j.jvca.2017.10.037.Peer-Reviewed Original ResearchThe effect of race on postsurgical ambulatory medical follow-up among United States Veterans
Schonberger RB, Dai F, Brandt C, Burg MM. The effect of race on postsurgical ambulatory medical follow-up among United States Veterans. Journal Of Clinical Anesthesia 2017, 40: 55-61. PMID: 28625448, PMCID: PMC5490668, DOI: 10.1016/j.jclinane.2016.11.002.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAmbulatory CareBlack or African AmericanComorbidityContinuity of Patient CareFemaleFollow-Up StudiesHealthcare DisparitiesHumansLong-Term CareMaleMiddle AgedPatient Acceptance of Health CareRetrospective StudiesSurgical Procedures, OperativeUnited StatesVeteransVeterans HealthYoung AdultConceptsAfrican American raceAfrican American patientsInternal medicineAmerican patientsAmbulatory internal medicineAmerican raceUS Veterans Affairs hospitalsYear of surgeryDay of surgeryVeterans Affairs hospitalUnited States veteransQuality improvement initiativesRetrospective observationalUS veteransHispanic ethnicityInpatient daysStates veteransSurgeryDecreased likelihoodEffect of raceImprovement initiativesVeteransFurther studiesPatientsAfrican Americans
2016
A Retrospective Observational Study of Anesthetic Induction Dosing Practices in Female Elderly Surgical Patients: Are We Overdosing Older Patients?
Akhtar S, Heng J, Dai F, Schonberger RB, Burg MM. A Retrospective Observational Study of Anesthetic Induction Dosing Practices in Female Elderly Surgical Patients: Are We Overdosing Older Patients? Drugs & Aging 2016, 33: 737-746. PMID: 27581549, DOI: 10.1007/s40266-016-0394-x.Peer-Reviewed Original ResearchConceptsDoses of fentanylOlder patientsFemale patientsInduction dosesGeneral anesthesiaObservational studyTertiary care academic hospitalElderly surgical patientsIncidence of hypotensionDose of propofolRetrospective observational studyOld female patientIntravenous anesthetic agentPost-induction hypotensionAge-associated differencesQuality improvement effortsResultsOlder patientsVasopressor therapyElderly patientsSurgical patientsYounger patientsBlood pressureHemodynamic outcomesASA-PSStudy designWeDoes intravenous induction dosing among patients undergoing gastrointestinal surgical procedures follow current recommendations: a study of contemporary practice
Akhtar S, Liu J, Heng J, Dai F, Schonberger RB, Burg MM. Does intravenous induction dosing among patients undergoing gastrointestinal surgical procedures follow current recommendations: a study of contemporary practice. Journal Of Clinical Anesthesia 2016, 33: 208-215. PMID: 27555166, DOI: 10.1016/j.jclinane.2016.02.001.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAgingAlgorithmsAnesthesia, IntravenousAnesthetics, IntravenousBody WeightDigestive System Surgical ProceduresFemaleFentanylGuidelines as TopicHumansHypotensionIntraoperative ComplicationsMaleMidazolamMiddle AgedPropofolRetrospective StudiesSeverity of Illness IndexConceptsASA-PS classAge groupsInduction dosesSurgical proceduresAnesthesiologists physical status classMean arterial pressure changesYounger groupOlder groupAge-adjusted doseRate of hypotensionMean arterial pressureRetrospective chart reviewAnesthetic induction agentGastrointestinal surgical proceduresArterial pressure changesGI surgical proceduresAcademic medical centerCochran-Armitage trend testDifferent age groupsPostinduction hypotensionOlder patientsAdult patientsArterial pressureChart reviewIntravenous induction
2015
Ambulatory Medical Follow-Up in the Year After Surgery and Subsequent Survival in a National Cohort of Veterans Health Administration Surgical Patients
Schonberger RB, Dai F, Brandt C, Burg MM. Ambulatory Medical Follow-Up in the Year After Surgery and Subsequent Survival in a National Cohort of Veterans Health Administration Surgical Patients. Journal Of Cardiothoracic And Vascular Anesthesia 2015, 30: 671-679. PMID: 27021176, PMCID: PMC5499041, DOI: 10.1053/j.jvca.2015.12.019.Peer-Reviewed Original ResearchConceptsFirst postoperative yearPostoperative yearNational cohortPostsurgical yearSurgical patientsLong-term postoperative survivalVeterans Health Administration facilitiesFirst postsurgical yearRetrospective cohort studyPostoperative year 1Day of surgeryAmbulatory medical careHazard of deathPostoperative year 2Medical Follow-UpYear 2US veterans' hospitalsYear 1Cause mortalityPostoperative survivalCohort studyPatient subgroupsCare coordinationFollow-upUS veterans
2014
Preoperative Depression Symptom Severity and Its Impact on Adherence to Preoperative Beta-Blocker Therapy
Schonberger RB, Feinleib J, Holt N, Dai F, Brandt C, Burg MM. Preoperative Depression Symptom Severity and Its Impact on Adherence to Preoperative Beta-Blocker Therapy. Journal Of Cardiothoracic And Vascular Anesthesia 2014, 28: 1467-1473. PMID: 25263776, PMCID: PMC4258545, DOI: 10.1053/j.jvca.2014.05.006.Peer-Reviewed Original ResearchConceptsBeta-blocker therapyDistressed personality typeMajor depressionChronic beta-blocker therapyPreoperative beta-blocker therapyRecent primary care visitBeta-blocker withdrawalMost surgical patientsUntreated major depressionPrimary care visitsProspective observational studyDay of surgeryPatient Health QuestionnaireDiagnosis of depressionMajor depressive disorderIndication of depressionSymptoms of depressionDepression symptom severityCare visitsSurgical patientsMedication nonadherenceDepression screeningTreatable conditionDepressive disorderSevere depressionHandheld Doppler to Improve Pulse Checks during Resuscitation of Putative Pulseless Electrical Activity Arrest
Schonberger RB, Lampert RJ, Mandel EI, Feinleib J, Gong Z, Honiden S. Handheld Doppler to Improve Pulse Checks during Resuscitation of Putative Pulseless Electrical Activity Arrest. Anesthesiology 2014, 120: 1042-1045. PMID: 24335750, PMCID: PMC3975650, DOI: 10.1097/aln.0000000000000106.Peer-Reviewed Original Research
2013
New Utility for an Old Tool
Odonkor CA, Schonberger RB, Dai F, Shelley KH, Silverman DG, Barash PG. New Utility for an Old Tool. American Journal Of Physical Medicine & Rehabilitation 2013, 92: 849-863. PMID: 24051992, PMCID: PMC3850792, DOI: 10.1097/phm.0b013e3182a51ac5.Peer-Reviewed Original ResearchConceptsElective ambulatory surgeryUnplanned admissionsAmbulatory surgeryGait speedOdds ratioPrimary outcomeDischarge readinessProspective observational cohort studyMultivariable logistic regression modelSeparate multivariable logistic regression modelsEarly home dischargeHome discharge timePreoperative gait speedObservational cohort studyTotal anesthesia timeAdjusted odds ratioGait speed testingLogistic regression modelsCohort studyHome dischargeCardiac surgeryAnesthesia timeHeart rateSurgeryAdmission
2006
Topical non-iontophoretic application of acetylcholine and nitroglycerin via a translucent patch: a new means for assessing microvascular reactivity.
Schonberger RB, Worden WS, Shahmohammadi K, Menn K, Silverman TJ, Stout RG, Shelley KH, Silverman DG. Topical non-iontophoretic application of acetylcholine and nitroglycerin via a translucent patch: a new means for assessing microvascular reactivity. The Yale Journal Of Biology And Medicine 2006, 79: 1-7. PMID: 17876370, PMCID: PMC1942174.Peer-Reviewed Original ResearchConceptsTransdermal deliveryLocal vasodilatory responseLaser Doppler flowmetry probeEndothelial cell functionTopical nitroglycerinMicrovascular reactivityVasodilatory responseLocal vasodilationMicrocirculatory changesVascular diseaseHealthy volunteersPlacebo sitesLDF monitoringLDF probeTranslucent patchesTherapeutic interventionsAcetylcholineNitroglycerinLDF readingsCell functionDrug applicationIontophoretic deliveryDrug preparationSuch dilationAcetylcholine chloride