Topical non-iontophoretic application of acetylcholine and nitroglycerin via a translucent patch: a new means for assessing microvascular reactivity.
Schonberger RB, Worden WS, Shahmohammadi K, Menn K, Silverman TJ, Stout RG, Shelley KH, Silverman DG. Topical non-iontophoretic application of acetylcholine and nitroglycerin via a translucent patch: a new means for assessing microvascular reactivity. The Yale Journal Of Biology And Medicine 2006, 79: 1-7. PMID: 17876370, PMCID: PMC1942174.Peer-Reviewed Original ResearchConceptsTransdermal deliveryLocal vasodilatory responseLaser Doppler flowmetry probeEndothelial cell functionTopical nitroglycerinMicrovascular reactivityVasodilatory responseLocal vasodilationMicrocirculatory changesVascular diseaseHealthy volunteersPlacebo sitesLDF monitoringLDF probeTranslucent patchesTherapeutic interventionsAcetylcholineNitroglycerinLDF readingsCell functionDrug applicationIontophoretic deliveryDrug preparationSuch dilationAcetylcholine chloride