2024
Macrophage Infusion Rescues Cisplatin (CP)-Induced AKI
Guo X, Xu L, Velazquez H, Chen T, Safirstein R, Desir G. Macrophage Infusion Rescues Cisplatin (CP)-Induced AKI. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.2024psy855fx. DOI: 10.1681/asn.2024psy855fx.Peer-Reviewed Original ResearchCOMBINED EFFECTS OF CHILD AND ADULT ELEVATED BLOOD PRESSURE ON ADULT SUBCLINICAL KIDNEY DAMAGE AND ALBUMINURIA: A 36-YEAR PROSPECTIVE COHORT STUDY
Wang Y, Jia H, Du M, Sun Y, Wang D, Hu G, Man Z, Chu C, Desir G, Safirstein R, Zheng X, Mu J. COMBINED EFFECTS OF CHILD AND ADULT ELEVATED BLOOD PRESSURE ON ADULT SUBCLINICAL KIDNEY DAMAGE AND ALBUMINURIA: A 36-YEAR PROSPECTIVE COHORT STUDY. Journal Of Hypertension 2024, 42: e204. DOI: 10.1097/01.hjh.0001021508.55729.ea.Peer-Reviewed Original ResearchPersistently elevated BPUrinary albumin-to-creatinine ratioAlbumin-to-creatinine ratioElevated BPSubclinical kidney damageIncreased riskBlood pressureAdult BPCreatinine ratioElevated urinary albumin-to-creatinine ratioEffects of childrenParticipants aged 6Self-reported useKidney damageRisk of chronic kidney diseaseAssociated with increased riskAssociated with increased risk of chronic kidney diseaseChildhood elevated BPNational Health Commission of the People's Republic of ChinaRisk of albuminuriaElevated blood pressureChronic kidney diseaseChildhood to adulthoodCohort studyLongitudinal cohort
2023
APOBEC-1 deletion enhances cisplatin-induced acute kidney injury
Guo X, Blanc V, Davidson N, Velazquez H, Chen T, Moledina D, Moeckel G, Safirstein R, Desir G. APOBEC-1 deletion enhances cisplatin-induced acute kidney injury. Scientific Reports 2023, 13: 22255. PMID: 38097707, PMCID: PMC10721635, DOI: 10.1038/s41598-023-49575-3.Peer-Reviewed Original ResearchmRNA Editing via the Apobec1 Gene Promotes Recovery from AKI
Guo X, Velazquez H, Xu L, Cheng Z, Chen T, Tian Y, Bewersdorf J, Blanc V, Davidson N, Safirstein R, Desir G. mRNA Editing via the Apobec1 Gene Promotes Recovery from AKI. Journal Of The American Society Of Nephrology 2023, 34: 451-451. DOI: 10.1681/asn.20233411s1451b.Peer-Reviewed Original ResearchRenalase Ameliorates AKI by Altering Mitochondrial Function to Induce Cellular Repair Mechanisms
Guo X, Chen R, Chen T, Safirstein R, Jonas E, Desir G. Renalase Ameliorates AKI by Altering Mitochondrial Function to Induce Cellular Repair Mechanisms. Journal Of The American Society Of Nephrology 2023, 34: 117-117. DOI: 10.1681/asn.20233411s1117b.Peer-Reviewed Original Research
2022
Apobec-1 Limits Cisplatin and Ischemia-Reperfusion-Induced AKI
Guo X, Xu L, Velazquez H, Chen T, Blanc V, Davidson N, Moeckel G, Safirstein R, Desir G. Apobec-1 Limits Cisplatin and Ischemia-Reperfusion-Induced AKI. Journal Of The American Society Of Nephrology 2022, 33: 359-360. DOI: 10.1681/asn.20223311s1359e.Peer-Reviewed Original ResearchRenalase Protects Renal Injury by Maintaining Mitochondrial Dynamic Homeostasis
Guo X, Chen R, Chen T, Moeckel G, Safirstein R, Jonas E, Desir G. Renalase Protects Renal Injury by Maintaining Mitochondrial Dynamic Homeostasis. Journal Of The American Society Of Nephrology 2022, 33: 359-359. DOI: 10.1681/asn.20223311s1359d.Peer-Reviewed Original ResearchEarly life body mass index trajectories and albuminuria in midlife: A 30-year prospective cohort study
Wang Y, Li F, Chu C, Zhang X, Zhang X, Liao Y, Du M, Zou T, Ma Q, Chen C, Wang D, Wang K, Yan Y, Sun Y, Hu G, Jia H, Li H, Niu Z, Yan R, Man Z, Wang L, Luo W, Zhang J, Li C, Lu W, Chang J, Safirstein R, Lu Y, Mu J. Early life body mass index trajectories and albuminuria in midlife: A 30-year prospective cohort study. EClinicalMedicine 2022, 48: 101420. PMID: 35516445, PMCID: PMC9065297, DOI: 10.1016/j.eclinm.2022.101420.Peer-Reviewed Original ResearchBody mass indexDistinct BMI trajectoriesFirst Affiliated HospitalBMI trajectoriesOdds ratioXi'an Jiaotong UniversityAffiliated HospitalCardiovascular diseaseBody mass index (BMI) trajectoriesClinical Research AwardHigher BMI trajectoriesProspective cohort studySystolic blood pressureRisk of albuminuriaUnadjusted odds ratioNon-communicable disease preventionHigher UACRCohort studyBlood pressureCreatinine ratioRenal diseaseUrinary albuminVascular dysfunctionBMI groupsStudy cohort
2021
Heightened Innate Immune Response to COVID-19 Infection in CKD: Implications to Poorer Outcome During CKD
Guo X, Xu L, Chen T, Gorelick F, Desir G, Safirstein R. Heightened Innate Immune Response to COVID-19 Infection in CKD: Implications to Poorer Outcome During CKD. Journal Of The American Society Of Nephrology 2021, 32: 749-749. DOI: 10.1681/asn.20213210s1749c.Peer-Reviewed Original Research
2020
Kidney Targeted Renalase Agonist Peptide Rescues Severe Model of Cisplatin-Induced AKI and CKD
Guo X, Xu L, Velazquez H, Chen T, Williams R, Heller D, Safirstein R, Desir G. Kidney Targeted Renalase Agonist Peptide Rescues Severe Model of Cisplatin-Induced AKI and CKD. Journal Of The American Society Of Nephrology 2020, 31: 230-230. DOI: 10.1681/asn.20203110s1230b.Peer-Reviewed Original ResearchApobec 1 Limits Cisplatin-Induced AKI by Regulating the Disposal of Pro-Ferroptotic Lipids
Guo X, Velazquez H, Chen T, Blanc V, Davidson N, Safirstein R, Desir G. Apobec 1 Limits Cisplatin-Induced AKI by Regulating the Disposal of Pro-Ferroptotic Lipids. Journal Of The American Society Of Nephrology 2020, 31: 123-123. DOI: 10.1681/asn.20203110s1123d.Peer-Reviewed Original Research
2013
Renalase protects against cisplatin acute kidney injury in mice
Desir G, Wang L, Velazquez H, Moeckel G, Safirstein R. Renalase protects against cisplatin acute kidney injury in mice. The FASEB Journal 2013, 27: 910.7-910.7. DOI: 10.1096/fasebj.27.1_supplement.910.7.Peer-Reviewed Original ResearchCisplatin acute kidney injuryAcute kidney injuryRenalase expressionKidney injuryCisplatin-induced acute kidney injuryIschemic acute kidney injuryRenal injury scoreUseful therapeutic optionHK-2 cellsImportant clinical syndromeRenalase deficiencyTubular necrosisPro-survival signalsTherapeutic optionsClinical syndromeInjury scorePlasma creatinineKO miceEffective therapyRenalaseBCL2 expressionMarked reductionProtective actionCaspase-3Injury