2024
Amygdala Cannabinoid 1 Receptor, Pain Response, and Emotional Numbing in Trauma-Exposed Individuals
Korem N, Hillmer A, D’Souza D, Nia A, Levy I, Pietrzak R, Harpaz-Rotem I. Amygdala Cannabinoid 1 Receptor, Pain Response, and Emotional Numbing in Trauma-Exposed Individuals. JAMA Network Open 2024, 7: e2432387. PMID: 39250156, PMCID: PMC11385051, DOI: 10.1001/jamanetworkopen.2024.32387.Peer-Reviewed Original ResearchAssociation patterns of antisocial personality disorder across substance use disorders
Low A, Stiltner B, Nunez Y, Adhikari K, Deak J, Pietrzak R, Kranzler H, Gelernter J, Polimanti R. Association patterns of antisocial personality disorder across substance use disorders. Translational Psychiatry 2024, 14: 346. PMID: 39198385, PMCID: PMC11358160, DOI: 10.1038/s41398-024-03054-z.Peer-Reviewed Original ResearchConceptsAntisocial personality disorderSubstance use disordersPersonality disorderUse disorderAssociation of antisocial personality disorderPresence of antisocial personality disorderPrevalence of antisocial personality disorderHazardous useDSM-5 SUD diagnosesSubstance use disorder severityDiagnostic criteriaInteraction effects with sexTobacco use disorderDSM-5Association of alcoholSUD diagnosisDisordersCocaineRacial/ethnic backgroundsIndividualsCocUDSeverityCannabisAssociation patternsAssociationMicroglia-mediated neuroimmune suppression in PTSD is associated with anhedonia
Bonomi R, Hillmer A, Woodcock E, Bhatt S, Rusowicz A, Angarita G, Carson R, Davis M, Esterlis I, Nabulsi N, Huang Y, Krystal J, Pietrzak R, Cosgrove K. Microglia-mediated neuroimmune suppression in PTSD is associated with anhedonia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2406005121. PMID: 39172786, PMCID: PMC11363315, DOI: 10.1073/pnas.2406005121.Peer-Reviewed Original ResearchConceptsPTSD groupPrefrontal-limbic circuitsNeuroimmune responseAssociated with anhedoniaPosttraumatic stress disorderPositron emission tomography brain imagingTranslocator protein availabilityBrain immune functionAnhedonic symptomsStress disorderPeripheral immune dysfunctionPTSDGroup differencesSeverity of symptomsPsychiatric diseasesTranslocator proteinBrain imagingAdministration of lipopolysaccharideSymptomsMicroglial markersLPS-induced increaseCompared to controlsImmune functionSickness symptomsAnhedoniaPsychological Factors, Physical Conditions, and Functioning Among US Veterans
Fischer I, Na P, Feldman D, Krist A, Kudler H, Jeste D, Pietrzak R. Psychological Factors, Physical Conditions, and Functioning Among US Veterans. JAMA Network Open 2024, 7: e2427382. PMID: 39120905, PMCID: PMC11316230, DOI: 10.1001/jamanetworkopen.2024.27382.Peer-Reviewed Original ResearchHelping the Helpers: Mental Health Challenges of Psychosocial Support Workers During the Russian-Ukrainian War
Kang H, Fischer I, Esterlis I, Kolyshkina A, Ponomarenko L, Chobanian A, Vus V, Pietrzak R. Helping the Helpers: Mental Health Challenges of Psychosocial Support Workers During the Russian-Ukrainian War. Disaster Medicine And Public Health Preparedness 2024, 18: e95. PMID: 38829179, DOI: 10.1017/dmp.2024.68.Peer-Reviewed Original ResearchConceptsPsychosocial support workersPosttraumatic stress disorderAssociated with greater oddsPresence of meaning in lifeMeaning in lifeSuicidal ideationMental health challengesGreater oddsMental healthLow optimismSupport workersHealth challengesMental health problemsCorrelates of burnoutPromote social connectednessStress disorderPsychosocial characteristicsGreater distressWar exposureGeneral populationHealth problemsSocial connectednessBurnoutOddsSocial relationshipsGenome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder
Nievergelt C, Maihofer A, Atkinson E, Chen C, Choi K, Coleman J, Daskalakis N, Duncan L, Polimanti R, Aaronson C, Amstadter A, Andersen S, Andreassen O, Arbisi P, Ashley-Koch A, Austin S, Avdibegoviç E, Babić D, Bacanu S, Baker D, Batzler A, Beckham J, Belangero S, Benjet C, Bergner C, Bierer L, Biernacka J, Bierut L, Bisson J, Boks M, Bolger E, Brandolino A, Breen G, Bressan R, Bryant R, Bustamante A, Bybjerg-Grauholm J, Bækvad-Hansen M, Børglum A, Børte S, Cahn L, Calabrese J, Caldas-de-Almeida J, Chatzinakos C, Cheema S, Clouston S, Colodro-Conde L, Coombes B, Cruz-Fuentes C, Dale A, Dalvie S, Davis L, Deckert J, Delahanty D, Dennis M, Desarnaud F, DiPietro C, Disner S, Docherty A, Domschke K, Dyb G, Kulenović A, Edenberg H, Evans A, Fabbri C, Fani N, Farrer L, Feder A, Feeny N, Flory J, Forbes D, Franz C, Galea S, Garrett M, Gelaye B, Gelernter J, Geuze E, Gillespie C, Goleva S, Gordon S, Goçi A, Grasser L, Guindalini C, Haas M, Hagenaars S, Hauser M, Heath A, Hemmings S, Hesselbrock V, Hickie I, Hogan K, Hougaard D, Huang H, Huckins L, Hveem K, Jakovljević M, Javanbakht A, Jenkins G, Johnson J, Jones I, Jovanovic T, Karstoft K, Kaufman M, Kennedy J, Kessler R, Khan A, Kimbrel N, King A, Koen N, Kotov R, Kranzler H, Krebs K, Kremen W, Kuan P, Lawford B, Lebois L, Lehto K, Levey D, Lewis C, Liberzon I, Linnstaedt S, Logue M, Lori A, Lu Y, Luft B, Lupton M, Luykx J, Makotkine I, Maples-Keller J, Marchese S, Marmar C, Martin N, Martínez-Levy G, McAloney K, McFarlane A, McLaughlin K, McLean S, Medland S, Mehta D, Meyers J, Michopoulos V, Mikita E, Milani L, Milberg W, Miller M, Morey R, Morris C, Mors O, Mortensen P, Mufford M, Nelson E, Nordentoft M, Norman S, Nugent N, O’Donnell M, Orcutt H, Pan P, Panizzon M, Pathak G, Peters E, Peterson A, Peverill M, Pietrzak R, Polusny M, Porjesz B, Powers A, Qin X, Ratanatharathorn A, Risbrough V, Roberts A, Rothbaum A, Rothbaum B, Roy-Byrne P, Ruggiero K, Rung A, Runz H, Rutten B, de Viteri S, Salum G, Sampson L, Sanchez S, Santoro M, Seah C, Seedat S, Seng J, Shabalin A, Sheerin C, Silove D, Smith A, Smoller J, Sponheim S, Stein D, Stensland S, Stevens J, Sumner J, Teicher M, Thompson W, Tiwari A, Trapido E, Uddin M, Ursano R, Valdimarsdóttir U, Van Hooff M, Vermetten E, Vinkers C, Voisey J, Wang Y, Wang Z, Waszczuk M, Weber H, Wendt F, Werge T, Williams M, Williamson D, Winsvold B, Winternitz S, Wolf C, Wolf E, Xia Y, Xiong Y, Yehuda R, Young K, Young R, Zai C, Zai G, Zervas M, Zhao H, Zoellner L, Zwart J, deRoon-Cassini T, van Rooij S, van den Heuvel L, Stein M, Ressler K, Koenen K. Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder. Nature Genetics 2024, 56: 792-808. PMID: 38637617, PMCID: PMC11396662, DOI: 10.1038/s41588-024-01707-9.Peer-Reviewed Original ResearchConceptsMeta-analysis of genome-wide association studiesGenome-wide significant lociMulti-ancestry meta-analysisGenome-wide association analysisGenome-wide association studiesIndividuals of European ancestryPotential causal genesNative American ancestryMulti-omics approachPost-traumatic stress disorderAdmixed individualsSignificant lociRisk lociCausal genesAssociation studiesAssociation analysisFunctional genesTranscription factorsGenetic studiesAmerican ancestryEuropean ancestryAxon guidanceSynaptic structureLociGenesFunctional significance of posttraumatic growth in U.S. military veterans
Gower T, Fischer I, Tsai J, Kang H, Na P, Tedeschi R, Pietrzak R. Functional significance of posttraumatic growth in U.S. military veterans. Journal Of Affective Disorders 2024, 356: 267-273. PMID: 38614442, DOI: 10.1016/j.jad.2024.04.046.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderPosttraumatic stress disorder symptomsPosttraumatic growthPsychosocial functioningTraumatic eventsTrauma-exposed U.S. veteransNational Health and ResilienceMale veteran samplePost-trauma functioningPattern of findingsRetrospective self-reportsU.S. military veteransVeteran sampleStress disorderVeterans StudyExamined relationsCross-sectional designMilitary veteransNationally representative sampleU.S. veteransAssociated with functionsPhysical functionClinical interventionsPsychosocial characteristicsVeteransDifferential associations of adverse childhood experiences and mental health outcomes in U.S. military veterans
Slavin A, Fischer I, Pietrzak R. Differential associations of adverse childhood experiences and mental health outcomes in U.S. military veterans. Journal Of Psychiatric Research 2024, 172: 261-265. PMID: 38412789, DOI: 10.1016/j.jpsychires.2024.02.040.Peer-Reviewed Original ResearchConceptsAdverse childhood experiencesMental health outcomesChildhood traumaEmotional neglectMilitary veteransChildhood experiencesNational Health and ResiliencePrevalence of childhood traumaAssociated with adverse mental health outcomesHealth outcomesChildhood emotional neglectPosttraumatic stress disorderEffects of adverse childhood experiencesU.S. military veteransAssociation of adverse childhood experiencesSample of veteransAdverse mental health outcomesAdverse mental health effectsStress disorderGeneralized anxietyPopulation-based sample of veteransVeterans StudySuicidal thoughtsPopulation-based sampleIndividual adverse childhood experiencesProblematic Alcohol Use Trajectories in U.S. Military Veterans during a Public Health Crisis: Results from a 3-year, Nationally Representative, Longitudinal Study
Na P, Fischer I, Petrakis I, Pietrzak R. Problematic Alcohol Use Trajectories in U.S. Military Veterans during a Public Health Crisis: Results from a 3-year, Nationally Representative, Longitudinal Study. Psychiatric Quarterly 2024, 95: 157-171. PMID: 38319532, DOI: 10.1007/s11126-024-10067-w.Peer-Reviewed Original ResearchConceptsDrug use disordersProblematic alcohol useAlcohol use trajectoriesLow social supportAdverse childhood experiencesAlcohol useGreater household incomeSocial supportUS veteransLongitudinal studyNational Health and ResilienceLatent growth mixture modelingU.S. military veteransHousehold incomeGrowth mixture modelingNon-household membersCOVID-19 pandemicVeterans StudyUse disorderMilitary veteransChildhood experiencesPublic health crisisPsychosocial characteristicsPrevention effortsVeteransGeneralized anxiety and mild anxiety symptoms in U.S. military veterans: Prevalence, characteristics, and functioning
Macdonald-Gagnon G, Stefanovics E, Potenza M, Pietrzak R. Generalized anxiety and mild anxiety symptoms in U.S. military veterans: Prevalence, characteristics, and functioning. Journal Of Psychiatric Research 2024, 171: 263-270. PMID: 38325107, DOI: 10.1016/j.jpsychires.2024.02.013.Peer-Reviewed Original ResearchConceptsGeneralized anxiety disorderMild anxiety symptomsAnxiety symptomsMilitary veteransU.S. veteransCorrelates of generalized anxiety disorderCorrelates of anxiety symptomsAnxiety symptom severityU.S. military veteransAnxiety disordersGeneralized anxietyPoor mental healthSuicidal thoughtsSymptom severityMental disordersExcessive anxietyAnxietyMagnitude associationsMental healthFunctional impairmentVeteransFunctional correlatesClinical samplesNationally representative sampleSymptomsThe mediating role of social support in associations between childhood adversity, military sexual trauma, and homelessness in a nationally representative sample of US veterans
Bulanchuk N, Edwards E, Pietrzak R, Tsai J. The mediating role of social support in associations between childhood adversity, military sexual trauma, and homelessness in a nationally representative sample of US veterans. Journal Of Community Psychology 2024, 52: 399-414. PMID: 38289875, DOI: 10.1002/jcop.23105.Peer-Reviewed Original ResearchConceptsMilitary sexual traumaAdverse childhood experiencesLifetime homelessnessSocial supportSexual traumaNationally representative sampleHistory of military sexual traumaCorrelates of homelessnessAvailability of social supportPerceived social supportInterpersonal social supportLow social supportRepresentative sampleChildhood adversityHomelessnessFemale veteransChildhood experiencesCommunity integrationMale counterpartsPath analysisVeteransUS veteransTrauma ratesNationalCorrelation analysisFirearm storage practices among military veterans in the United States: Findings from a nationally representative survey
Nichter B, Hill M, Fischer I, Panza K, Kline A, Na P, Norman S, Rowcliffe M, Pietrzak R. Firearm storage practices among military veterans in the United States: Findings from a nationally representative survey. Journal Of Affective Disorders 2024, 351: 82-89. PMID: 38280567, DOI: 10.1016/j.jad.2024.01.179.Peer-Reviewed Original ResearchConceptsFirearm storage practicesContemporary population-based dataNational Health and ResiliencePromote safe firearm storageTrauma exposureAssociated with increased risk of suicidePopulation-based dataCross-sectional designStorage of firearmsAssociated with increased riskRisk of suicideNationally representative surveyDrug use disordersHealthcare professionalsSociodemographic characteristicsVeterans StudyFirearm storageTraumatic brain injuryU.S. veteransService membersMilitary veteransStorage practicesTraining initiativesVeteransRisk statusFunctional correlates of a novel 8-factor model of PTSD in U.S. military veterans: Results from the National Health and Resilience in Veterans Study
Stiltner B, Fischer I, Duek O, Polimanti R, Harpaz-Rotem I, Pietrzak R. Functional correlates of a novel 8-factor model of PTSD in U.S. military veterans: Results from the National Health and Resilience in Veterans Study. Journal Of Psychiatric Research 2024, 171: 69-74. PMID: 38244335, DOI: 10.1016/j.jpsychires.2024.01.017.Peer-Reviewed Original ResearchConceptsModels of posttraumatic stress disorderPosttraumatic stress disorderNational Health and ResilienceU.S. military veteransArousal symptomsSuicidal ideationVeterans StudyCurrent depressionSymptom clustersMilitary veteransPosttraumatic stress disorder symptom clustersPosttraumatic stress disorder symptomsPosttraumatic Stress Disorder ChecklistAnxious arousal symptomsDysphoric arousal symptomsIntrusive symptom clustersOdds of suicidal ideationFunctional correlatesMulti-faceted disorderExternalizing behavioral symptomsAssociated with lower oddsAssociated with higher oddsSymptom structureAvoidance symptomsDSM-5
2023
Functional decline during the COVID‐19 pandemic among U.S. military veterans: Results from the National Health and Resilience in Veterans Study
Morse J, Fischer I, Na P, Afari N, Pietrzak R. Functional decline during the COVID‐19 pandemic among U.S. military veterans: Results from the National Health and Resilience in Veterans Study. International Journal Of Geriatric Psychiatry 2023, 38: e6040. PMID: 38072628, DOI: 10.1002/gps.6040.Peer-Reviewed Original ResearchConceptsAdverse childhood experiencesFunctional declineU.S. military veteransGreater adverse childhood experiencesNational HealthPhysical functioningVeterans StudyIdentification of veteransSubstantial health problemPhysical functional declineMilitary veteransMental functioningU.S. adult populationStress symptomsStrongest correlatePrevalence of veteransProtective psychosocial characteristicsMultivariable analysisPosttraumatic stress symptomsHealth problemsU.S. veteransAdult populationImprovement 1Coronavirus diseaseOlder ageWell-Being of US Military Veterans
Na P, Fischer I, Krist A, Kudler H, Jeste D, Pietrzak R. Well-Being of US Military Veterans. JAMA Network Open 2023, 6: e2346709. PMID: 38060229, PMCID: PMC10704281, DOI: 10.1001/jamanetworkopen.2023.46709.Peer-Reviewed Original ResearchEvaluating a novel 8-factor dimensional model of PTSD in U.S. military veterans: Results from the National Health and Resilience in Veterans Study
Stiltner B, Fischer I, Duek O, Polimanti R, Harpaz-Rotem I, Pietrzak R. Evaluating a novel 8-factor dimensional model of PTSD in U.S. military veterans: Results from the National Health and Resilience in Veterans Study. Journal Of Affective Disorders 2023, 346: 303-307. PMID: 37979626, DOI: 10.1016/j.jad.2023.11.041.Peer-Reviewed Original ResearchConceptsIndex traumaPTSD symptomsNational HealthPosttraumatic stress disorder (PTSD) symptomsVeterans StudyMilitary veteransTrauma-exposed populationsClinician-administered interviewU.S. military veteransConfirmatory factor analysisDSM-5 modelStrong significant associationTrauma exposureIntrusive symptomsDisorder symptomsCombat exposureHigh riskU.S. veteransDSM-5Significant associationSymptomsInterpersonal violenceFactor analysisPTSDScarce researchClinical significance of novel 8-factor model of DSM-5 PTSD in national VA PTSD residential treatment data: Internally- v. externally-cued intrusions
Gross G, Spiller T, Duek O, Pietrzak R, Harpaz-Rotem I. Clinical significance of novel 8-factor model of DSM-5 PTSD in national VA PTSD residential treatment data: Internally- v. externally-cued intrusions. Journal Of Affective Disorders 2023, 328: 255-260. PMID: 36806596, DOI: 10.1016/j.jad.2023.02.046.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderPTSD symptomsDysphoric arousalDSM-5 posttraumatic stress disorderDSM-5 PTSD symptomsDistinct underlying processesSelf-report measuresGeneralized anxiety symptomsSuperior model fitPhysical health functioningCore defining featuresStructural equation modelingWorse emotional functioningAnxious arousalSymptoms of depressionNegative affectIntrusion symptomsGreater avoidanceEmotional functioningStress disorderAnxiety symptomsPTSD ChecklistIntrusion factorCross-sectional designGeneralized anxietyPrevalence, Correlates, and Psychiatric Burden of Prolonged Grief Disorder in U.S. Military Veterans: Results From a Nationally Representative Study
Na P, Fischer I, Shear K, Pietrzak R. Prevalence, Correlates, and Psychiatric Burden of Prolonged Grief Disorder in U.S. Military Veterans: Results From a Nationally Representative Study. American Journal Of Geriatric Psychiatry 2023, 31: 543-548. PMID: 36878740, PMCID: PMC11143540, DOI: 10.1016/j.jagp.2023.02.007.Peer-Reviewed Original ResearchConceptsIndependent risk factorMajor depressive disorderUnited States veteransCoronavirus disease 2019Substance use disordersPost-traumatic stress disorderGrief disorderAdverse childhood experiencesNon-natural causesU.S. military veteransPoint prevalenceNationally Representative StudyFemale sexNational HealthRepresentative studyRisk factorsDepressive disorderPsychiatric burdenDisease 2019States veteransAdditional adjustmentPsychiatric disordersProlonged Grief DisorderUse disordersU.S. veteransSex-specific risk and resilience correlates of suicidal ideation in U.S. military veterans
Stefanovics E, Potenza M, Tsai J, Nichter B, Pietrzak R. Sex-specific risk and resilience correlates of suicidal ideation in U.S. military veterans. Journal Of Affective Disorders 2023, 328: 303-311. PMID: 36775254, DOI: 10.1016/j.jad.2023.02.025.Peer-Reviewed Original ResearchConceptsSuicidal ideationMale veteransFemale veteransU.S. military veteransRisk factorsGender-specific risk factorsPrevalence of SISex-specific riskMilitary veteransDifferent risk factorsAlcohol use disorderLow psychological resilienceMultivariable analysisNational HealthRepresentative sampleUse disordersU.S. veteransVeterans StudySuicide preventionTreatment effortsVeteransLow purposeStrongest correlatePrevalenceIdeationInteractive association of posttraumatic stress disorder, apolipoprotein ε4 genotype, and age on cognitive functioning
Lawrence K, Rippey C, Welikson B, Pietrzak R, Adams T. Interactive association of posttraumatic stress disorder, apolipoprotein ε4 genotype, and age on cognitive functioning. International Journal Of Geriatric Psychiatry 2023, 38: e5888. PMID: 36757293, PMCID: PMC10168127, DOI: 10.1002/gps.5888.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderThree-way interactionCognitive functioningStress disorderOlder participantsTreatment of PTSDMain effectProbable posttraumatic stress disorderAge-related cognitive impairmentAPOE ε4U.S. military veteransApolipoprotein ε4 genotypeCognitive deficitsPsychomotor performanceAge-related associationsInteractive associationsVeterans StudyMilitary veteransCognitive impairmentPreliminary evidenceTwo-way interactionAPM performanceΕ4 carriersAnalysis of covarianceFunctioning