2024
Unraveling PTSD: Symptom Cluster Change During and 1 Year After Veterans’ Residential PTSD Treatment
Gross G, Spiller T, Ben-Zion Z, Rubenstein A, Pietrzak R, Duek O, Hoff R, Harpaz-Rotem I. Unraveling PTSD: Symptom Cluster Change During and 1 Year After Veterans’ Residential PTSD Treatment. Psychological Trauma Theory Research Practice And Policy 2024 PMID: 38990694, DOI: 10.1037/tra0001734.Peer-Reviewed Original ResearchPosttraumatic stress disorderPosttraumatic stress disorder symptom clustersPosttraumatic stress disorder clustersSymptom clustersIntrusive symptomsResidential treatmentTreatment of posttraumatic stress disorderPosttraumatic stress disorder symptomsResidential PTSD treatmentPTSD symptom clustersNovel treatment interventionsDifferential treatment responseReduce symptom severityDifferential patterns of changeAvoidance symptomsPTSD treatmentTreatment gainsStress disorderVeterans AffairsSymptom severityCluster CTreatment interventionsCluster BIndividual symptomsCohort of veteransSuicide-Specific Cognitions and Suicidal Behavior in U.S. Military Veterans
Fischer I, Nichter B, Trachik B, Bryan C, Pietrzak R. Suicide-Specific Cognitions and Suicidal Behavior in U.S. Military Veterans. Psychiatry 2024, 87: 241-250. PMID: 38832675, DOI: 10.1080/00332747.2024.2352883.Peer-Reviewed Original ResearchSuicide-specific cognitionsU.S. military veteransMilitary veteransSuicidal ideationSuicide planLifetime history of suicide attemptsHistory of suicide attemptsAssociated with suicidal ideationSuicide Cognitions ScaleDepressive symptom severityThoughts of suicideMitigate suicide riskB-SCSAdverse childhood experiencesExploratory post hoc analysisSuicidal behaviorLifetime historySuicide riskSuicide attemptsSymptom severitySuicidal thoughtsCognitive scalesIndicator of riskChildhood experiencesIntervention effortsUsing the Moral Injury and Distress Scale to identify clinically meaningful moral injury
Maguen S, Griffin B, Pietrzak R, McLean C, Hamblen J, Norman S. Using the Moral Injury and Distress Scale to identify clinically meaningful moral injury. Journal Of Traumatic Stress 2024, 37: 685-696. PMID: 38655683, DOI: 10.1002/jts.23050.Peer-Reviewed Original ResearchPotentially morally injurious eventsTrauma-related guiltMoral injuryCut scoresClinically significant mental health symptomsSignificant mental health symptomsExposure to potentially morally injurious eventsSample of military veteransMental health symptomsPopulation-based sampleHealth care workersRisk of negative outcomesFunctional impairmentDepressive symptom severityMorally injurious eventsInjury carePMIE exposureNon-HispanicMental healthHealth symptomsCare workersInjury eventsPosttraumatic stressMilitary veteransSymptom severityGeneralized anxiety and mild anxiety symptoms in U.S. military veterans: Prevalence, characteristics, and functioning
Macdonald-Gagnon G, Stefanovics E, Potenza M, Pietrzak R. Generalized anxiety and mild anxiety symptoms in U.S. military veterans: Prevalence, characteristics, and functioning. Journal Of Psychiatric Research 2024, 171: 263-270. PMID: 38325107, DOI: 10.1016/j.jpsychires.2024.02.013.Peer-Reviewed Original ResearchConceptsGeneralized anxiety disorderMild anxiety symptomsAnxiety symptomsMilitary veteransU.S. veteransCorrelates of generalized anxiety disorderCorrelates of anxiety symptomsAnxiety symptom severityU.S. military veteransAnxiety disordersGeneralized anxietyPoor mental healthSuicidal thoughtsSymptom severityMental disordersExcessive anxietyAnxietyMagnitude associationsMental healthFunctional impairmentVeteransFunctional correlatesClinical samplesNationally representative sampleSymptoms
2023
Posttraumatic Growth in U.S. Military Veterans: Results from the National Health and Resilience in Veterans Study
Kang H, Fischer I, Dickinson S, Na P, Tsai J, Tedeschi R, Pietrzak R. Posttraumatic Growth in U.S. Military Veterans: Results from the National Health and Resilience in Veterans Study. Psychiatric Quarterly 2023, 95: 17-32. PMID: 37938492, DOI: 10.1007/s11126-023-10061-8.Peer-Reviewed Original ResearchPosttraumatic growthU.S. military veteransPTSD symptomsTraumatic eventsPosttraumatic stress disorder (PTSD) symptomsPositive psychological changesVeterans StudyMilitary veteransGreater posttraumatic growthTrauma-exposed veteransIntrinsic religiosityPTSD symptom severitySevere PTSD symptomsHigh-risk sampleIntrusive symptomsDisorder symptomsPsychological changesPTG levelsTraumatic experiencesPTSD ChecklistVeteran samplePsychosocial characteristicsSymptom clustersDSM-5Symptom severity
2020
PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies
Bhatt S, Hillmer AT, Girgenti MJ, Rusowicz A, Kapinos M, Nabulsi N, Huang Y, Matuskey D, Angarita GA, Esterlis I, Davis MT, Southwick SM, Friedman MJ, Duman R, Carson R, Krystal J, Pietrzak R, Cosgrove K. PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies. Nature Communications 2020, 11: 2360. PMID: 32398677, PMCID: PMC7217830, DOI: 10.1038/s41467-020-15930-5.Peer-Reviewed Original ResearchMeSH KeywordsAcetamidesAdaptor Proteins, Signal TransducingAdultBrainCase-Control StudiesFemaleGene Expression ProfilingHealthy VolunteersHumansMaleMicrogliaMiddle AgedPositron-Emission TomographyPyridinesRadiopharmaceuticalsReceptors, GABAReceptors, Tumor Necrosis Factor, Member 14Sex FactorsStress Disorders, Post-TraumaticYoung AdultConceptsPosttraumatic stress disorderPeripheral immune activationImmune activationHigher C-reactive protein levelsC-reactive protein levelsTSPO availabilityTranslocator proteinBrain microglial activationTomography brain imagingStress-related pathophysiologyPositron emission tomography (PET) brain imagingNeuroimmune activationMicroglial activationPTSD symptom severityImmunologic regulationPostmortem studiesPTSD subgroupHealthy individualsSymptom severityTrauma exposurePTSD groupStress disorderLower relative expressionBrain imagingPET imaging