Genetic liability to suicidal thoughts and behaviors and risk of suicide attempt in US military veterans: moderating effects of cumulative trauma burden
Nichter B, Koller D, De Angelis F, Wang J, Girgenti M, Na P, Hill M, Norman S, Krystal J, Gelernter J, Polimanti R, Pietrzak R. Genetic liability to suicidal thoughts and behaviors and risk of suicide attempt in US military veterans: moderating effects of cumulative trauma burden. Psychological Medicine 2022, 53: 6325-6333. PMID: 36444557, DOI: 10.1017/s0033291722003646.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresUS military veteransLifetime suicide attemptsSuicide attemptsTrauma exposureTrauma burdenGenetic liabilityMilitary veteransDrug repurposing analysisPopulation-based sampleCumulative trauma exposureLifetime trauma exposureLow trauma exposureSuicide prediction modelsChronic inflammationInflammatory processNervous system developmentRisk scorePsychiatric characteristicsSuicidal behaviorExposure interactionsLarge genome-wide association studiesHigh levelsVeteransSuicidalityDownstream consequences of moral distress in COVID-19 frontline healthcare workers: Longitudinal associations with moral injury-related guilt
Fischer I, Norman S, Feder A, Feingold J, Peccoralo L, Ripp J, Pietrzak R. Downstream consequences of moral distress in COVID-19 frontline healthcare workers: Longitudinal associations with moral injury-related guilt. General Hospital Psychiatry 2022, 79: 158-161. PMID: 36403350, PMCID: PMC9664834, DOI: 10.1016/j.genhosppsych.2022.11.003.Peer-Reviewed Original ResearchConceptsHealthcare workersMoral distressLongitudinal associationsCOVID-19 healthcare workersFrontline healthcare workersCOVID-19 pandemicDevelopment of MIOccupational cohortEarly intervention effortsSocial supportIntervention effortsInitial peakMonthsAssociationMoral injuryMIDistressNew York CityPotential moderatorsHigh levelsPandemicDownstream consequencesGreater levelsInjuryCohort