1986
Changes in the phenotype of human small cell lung cancer cell lines after transfection and expression of the c-myc proto-oncogene.
Johnson B, Battey J, Linnoila I, Becker K, Makuch R, Snider R, Carney D, Minna J. Changes in the phenotype of human small cell lung cancer cell lines after transfection and expression of the c-myc proto-oncogene. Journal Of Clinical Investigation 1986, 78: 525-532. PMID: 3016030, PMCID: PMC423589, DOI: 10.1172/jci112604.Peer-Reviewed Original ResearchConceptsSmall cell lung cancer cell linesCell lung cancer cell linesLung cancer cell linesCancer cell linesBombesin-like immunoreactivityLarge cell morphologyC-myc messenger RNAC-myc expressionC-MycCell linesSmall cell lung cancerHuman small cell lung cancer cell linesCell lung cancerSmall cell lung cancer linesCell lung cancer linesMessenger RNALung cancer linesC-myc amplificationC-myc geneLung cancerVariant phenotypesCloning efficiencyDecarboxylase levelsCancer linesBiologic properties
1980
Direct cloning of human neuroblastoma cells in soft agar culture.
Von Hoff D, Casper J, Bradley E, Trent J, Hodach A, Reichert C, Makuch R, Altman A. Direct cloning of human neuroblastoma cells in soft agar culture. Cancer Research 1980, 40: 3591-7. PMID: 7002289.Peer-Reviewed Original ResearchConceptsSoft agar systemNeuroblastoma cellsBone marrowPositive bone marrowHuman neuroblastoma cellsBasic science studiesAgar systemNumber of coloniesMarrow examinationStem cell assayClinical courseLymph nodesPoor prognosisSoft agar cultureTumor responseCatecholamine secretionHistological statusMarrow samplesTumor relapseSoft agar techniquePatientsSolid tumorsPathology studiesCulture resultsNegative specimens