Cyclic alternating combination chemotherapy for small cell bronchogenic carcinoma.
Cohen M, Ihde D, Bunn P, Fossieck B, Matthews M, Shackney S, Johnston-Early A, Makuch R, Minna J. Cyclic alternating combination chemotherapy for small cell bronchogenic carcinoma. Journal Of The National Cancer Institute 1979, 63: 163-70. PMID: 221114.Peer-Reviewed Original ResearchConceptsSmall cell bronchogenic carcinomaResistant drug combinationsCell bronchogenic carcinomaCR rateCombination chemotherapyComplete responseBronchogenic carcinomaDrug combinationsExtensive disease patientsLimited disease patientsProtocol-eligible patientsHigh-dose cyclophosphamideBrain radiation therapyDisease-free survivalComplete respondersDrug regimensProlong survivalInitial treatmentRadiation therapyPatientsVP-16ChemotherapyCarcinomaSequential useMonthscis-Dichlorodiammineplatinum(II) for the treatment of advanced ovarian cancer.
Young R, Von Hoff D, Gormley P, Makuch R, Cassidy J, Howser D, Bull J. cis-Dichlorodiammineplatinum(II) for the treatment of advanced ovarian cancer. Journal Of The National Cancer Institute 1979, 63: 1539-44. PMID: 387224.Peer-Reviewed Original ResearchConceptsCombination chemotherapy studiesAdvanced ovarian cancerSingle-agent activityOverall response rateLife-table analysisOvarian Cancer StudyEvaluable patientsForced diuresisSubstantial nauseaHematologic toxicityChemotherapy studiesRenal toxicityOvarian adenocarcinomaOvarian cancerResponse ratePatientsCancer studiesTreatmentToxicityNauseaVomitingDiuresisAdenocarcinomaMajor roleTherapy