2000
Outcome of Children in the Indomethacin Intraventricular Hemorrhage Prevention Trial
Ment L, Vohr B, Allan W, Westerveld M, Sparrow S, Schneider K, Katz K, Duncan C, Makuch R. Outcome of Children in the Indomethacin Intraventricular Hemorrhage Prevention Trial. Pediatrics 2000, 105: 485-491. PMID: 10699097, DOI: 10.1542/peds.105.3.485.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Inflammatory Agents, Non-SteroidalBrain Damage, ChronicCerebral HemorrhageCerebral VentriclesChild, PreschoolDose-Response Relationship, DrugFemaleFollow-Up StudiesHumansIndomethacinInfantInfant, NewbornInfant, Premature, DiseasesMaleNeurologic ExaminationNeuropsychological TestsPregnancyConceptsLow-dose indomethacinIntraventricular hemorrhagePlacebo childrenIndomethacin therapyPreterm infantsEarly administrationNeurologic examinationPrevention trialsLow birth weight preterm infantsStudy childrenBirth weight preterm infantsSeverity of IVHLow birth weight survivorsMean gestational ageWeight preterm infantsAdverse neurodevelopmental outcomesOutcome of childrenStandard neurologic examinationYears of ageNeurodevelopmental handicapPreterm neonatesNeurodevelopmental examinationNeurodevelopmental outcomesCerebral palsyGestational age
1999
The Etiology and Outcome of Cerebral Ventriculomegaly at Term in Very Low Birth Weight Preterm Infants
Ment L, Vohr B, Allan W, Westerveld M, Katz K, Schneider K, Makuch R. The Etiology and Outcome of Cerebral Ventriculomegaly at Term in Very Low Birth Weight Preterm Infants. Pediatrics 1999, 104: 243-248. PMID: 10429002, DOI: 10.1542/peds.104.2.243.Peer-Reviewed Original ResearchConceptsBronchopulmonary dysplasiaPreterm infantsCorrected ageIndependent predictorsCerebral ventriculomegalyBirth weightGrade 3Low birth weight preterm infantsBirth weight preterm infantsMaternal educationLow birth weight survivorsCause of ventriculomegalyDevelopment of ventriculomegalyGrades of IVHIncidence of handicapWeight preterm infantsMonths' corrected ageAdverse neurodevelopmental outcomesLow birth weightYears' corrected ageAdverse cognitive outcomesLogistic regression analysisYears of ageApgar scoreNeurodevelopmental handicapEarly-onset intraventricular hemorrhage in preterm neonates: Incidence of neurodevelopmental handicap
Vohr B, Allan W, Scott D, Katz K, Schneider K, Makuch R, Ment L. Early-onset intraventricular hemorrhage in preterm neonates: Incidence of neurodevelopmental handicap. Seminars In Perinatology 1999, 23: 212-217. PMID: 10405190, DOI: 10.1016/s0146-0005(99)80065-2.Peer-Reviewed Original ResearchConceptsIntraventricular hemorrhageEarly intraventricular hemorrhageLow birth weight infantsBirth weight infantsHours of lifeYears of agePostnatal indomethacinNeurodevelopmental handicapWeight infantsPreterm infantsPreterm neonatesNeurodevelopmental outcomesNeurological examinationCerebral palsyPostnatal hoursStudy infantsHigh riskMotor handicapIntelligence quotient scoresInfantsEarly onsetHemorrhageAgeQuotient scoresChildren
1998
Association of chronic sublethal hypoxia with ventriculomegaly in the developing rat brain
Ment L, Schwartz M, Makuch R, Stewart W. Association of chronic sublethal hypoxia with ventriculomegaly in the developing rat brain. Brain Research 1998, 111: 197-203. PMID: 9838111, DOI: 10.1016/s0165-3806(98)00139-4.Peer-Reviewed Original ResearchConceptsChronic sublethal hypoxiaSublethal hypoxiaBronchopulmonary dysplasiaAnimal modelsExperimental rat pupsSystemic blood pressureSubcortical white matterCorpus callosum sizePostnatal day 3Third groupNeurodevelopmental handicapPreterm infantsProlonged hypoxemiaBlood pressureCerebral ventriculomegalyExperimental time pointsChronic hypoxiaControl ratsCortical volumeRat pupsCallosum sizeNewborn ratsRat brainBody weightDay 3
1994
Low-dose indomethacin and prevention of intraventricular hemorrhage: a multicenter randomized trial.
Ment L, Ehrenkranz R, Duncan C, Scott D, Taylor K, Katz K, Schneider K, Makuch R, Oh W, Vohr B, Philip A, Allan W. Low-dose indomethacin and prevention of intraventricular hemorrhage: a multicenter randomized trial. Pediatrics 1994, 93: 543-50. PMID: 8134206, DOI: 10.1542/peds.93.4.543.Peer-Reviewed Original ResearchConceptsLow birth weight neonatesSeverity of IVHBirth weight neonatesIntraventricular hemorrhageWeight neonatesDose indomethacinBirth weightGrade 4 intraventricular hemorrhageSerial cranial ultrasound examinationsSignificant adverse drug eventsPercent of neonatesPlacebo-controlled trialPatent ductus arteriosusCranial ultrasound examinationMajor risk factorAdverse drug eventsHours of ageFirst postnatal dayDuctal closureProphylactic indomethacinApgar scoreNeurodevelopmental handicapParenchymal involvementPlacebo groupAdverse events