1983
Role of prophylactic cranial irradiation in prevention of central nervous system metastases in small cell lung cancer Potential benefit restricted to patients with complete response
Rosen S, Makuch R, Lichter A, Ihde D, Matthews M, Minna J, Glatstein E, Bunn P. Role of prophylactic cranial irradiation in prevention of central nervous system metastases in small cell lung cancer Potential benefit restricted to patients with complete response. The American Journal Of Medicine 1983, 74: 615-624. PMID: 6301274, DOI: 10.1016/0002-9343(83)91019-7.Peer-Reviewed Original ResearchConceptsCentral nervous system metastasesProphylactic cranial irradiationNervous system metastasesCranial irradiationComplete responsePrognostic featuresSystemic therapyCentral nervous system relapseSmall cell lung cancerInvolvement of liverPercent of patientsNervous system relapseSystemic combination chemotherapySubset of patientsTwo-year survivalCell lung cancerStage of diseaseCentral nervous systemNational Cancer InstituteChest irradiationComplete remissionEpidural metastasesOverall survivalCombination chemotherapyIntracerebral metastases
1982
The clinical behavior of „mixed”︁ small cell/large cell bronchogenic carcinoma compared to „pure”︁ small cell subtypes
Radice P, Matthews M, Ihde D, Gazdar A, Carney D, Bunn P, Cohen M, Fossieck B, Makuch R, Minna J. The clinical behavior of „mixed”︁ small cell/large cell bronchogenic carcinoma compared to „pure”︁ small cell subtypes. Cancer 1982, 50: 2894-2902. PMID: 6291745, DOI: 10.1002/1097-0142(19821215)50:12<2894::aid-cncr2820501232>3.0.co;2-g.Peer-Reviewed Original ResearchConceptsSmall cell carcinomaSmall cell subtypeCell carcinomaResponse rateCombination chemotherapyClinical behaviorLong-term disease-free survivalCentral nervous system metastasesSmall cell carcinoma casesUntreated lung cancer patientsCell subtypesSmall cell lung cancerAggressive chemotherapy protocolsDistinct pathologic variantComplete response rateNervous system metastasesCell bronchogenic carcinomaDisease-free survivalIntensive combination chemotherapySmall cell cancerExtent of diseaseLarge cell carcinomaCell lung cancerLung cancer patientsLarge cell component