1980
Serum glycoproteins in cancer patients: First report of correlations with in vitro and in vivo parameters of cellular immunity
Baskies A, Chretien P, Weiss J, Makuch R, Beveridge R, Catalona W, Spiegel H. Serum glycoproteins in cancer patients: First report of correlations with in vitro and in vivo parameters of cellular immunity. Cancer 1980, 45: 3050-3060. PMID: 7388749, DOI: 10.1002/1097-0142(19800615)45:12<3050::aid-cncr2820451229>3.0.co;2-8.Peer-Reviewed Original ResearchConceptsDepressed cellular immunityLymphocyte reactivityCellular immunityCancer patientsAlpha 2 HS-glycoproteinAlbumin levelsTumor extentHS-glycoproteinVivo parametersLevels of haptoglobinLevels of APPSerum glycoprotein levelsSerum protein levelsSerum glycoproteinsOngoing trialsPreoperative patientsRegional tumorsSerum levelsImmune statusImmunologic functionSolid malignanciesNormal controlsPatientsGlycoprotein levelsPrimary site
1979
Serum glycoproteins in head and neck squamous carcinoma Correlations with tumor extent, clinical tumor stage, and T-cell levels during chemotherapy
Wolf G, Chretien P, Elias E, Makuch R, Baskies A, Spiegel H, Weiss J. Serum glycoproteins in head and neck squamous carcinoma Correlations with tumor extent, clinical tumor stage, and T-cell levels during chemotherapy. The American Journal Of Surgery 1979, 138: 489-500. PMID: 90464, DOI: 10.1016/0002-9610(79)90407-0.Peer-Reviewed Original ResearchConceptsΑ1-acid glycoprotein levelsT cell levelsTumor stageAcute phase proteinsUntreated patientsSerum levelsTumor extentCellular immunityImmune reactivitySquamous carcinomaPhase proteinsGlycoprotein levelsSpecific acute phase proteinsCompletion of chemotherapyClinical tumor stageChronic cigarette smokersΑ1-antitrypsin levelsΑ1-antitrypsinCellular immune parametersNeck squamous carcinomaPreoperative chemotherapyRecurrent carcinomaAlbumin levelsControl patientsRegional metastasesThymosin immunotherapy in patients with small cell carcinoma of the lung. Correlation of in vitro studies with clinical course
Lipson S, Chretien P, Makuch R, Kenady D, Cohen M. Thymosin immunotherapy in patients with small cell carcinoma of the lung. Correlation of in vitro studies with clinical course. Cancer 1979, 43: 863-870. PMID: 218717, DOI: 10.1002/1097-0142(197903)43:3<863::aid-cncr2820430313>3.0.co;2-5.Peer-Reviewed Original ResearchConceptsTotal T cellsPretreatment CEA levelsT cellsCEA levelsClinical courseCellular immunityTumor responsePretreatment levelsCarcinoembryonic antigenAdministration of thymosinIntensive chemotherapy programsPeripheral blood levelsSmall cell carcinomaDuration of responseOverall tumor responseThymus-dependent lymphocytesLarger patient populationType of treatmentP groupMechanism of actionComplete remissionT60 groupChemotherapy programBronchogenic carcinomaImmune defectsEffects of Thymosin Fraction 5 in Cancer Patients: In Vitro Studies and Correlations with Clinical Course in Patients Receiving Thymosin
Chretien P, Lipson S, Makuch R, Kenady D, Snyder J, Cohen M. Effects of Thymosin Fraction 5 in Cancer Patients: In Vitro Studies and Correlations with Clinical Course in Patients Receiving Thymosin. 1979, 159-166. DOI: 10.1016/b978-0-08-023194-5.50023-1.Peer-Reviewed Original ResearchT cell levelsThymosin fraction 5Cancer patientsClinical coursePatient groupT cellsLow CEA levelWeeks of therapyCell-mediated immunityEffect of thymosinSmall cell carcinomaSuch patient groupsComplete tumor remissionFraction 5Certain serum glycoproteinsSimilar groupsAdjuvant treatmentIntensive chemotherapyImmunologic effectsCEA levelsFurther therapyImmune defectsCellular immunityCell carcinomaTumor remission
1978
Thymosin in cancer patients: in vitro effects and correlations with clinical response to thymosin immunotherapy.
Chretien P, Lipson S, Makuch R, Kenady D, Cohen M, Minna J. Thymosin in cancer patients: in vitro effects and correlations with clinical response to thymosin immunotherapy. Journal Of The National Cancer Institute 1978, 62: 1787-90. PMID: 215307.Peer-Reviewed Original Research