2014
Enhanced excitability of MRGPRA3- and MRGPRD-positive nociceptors in a model of inflammatory itch and pain
Qu L, Fan N, Ma C, Wang T, Han L, Fu K, Wang Y, Shimada SG, Dong X, LaMotte RH. Enhanced excitability of MRGPRA3- and MRGPRD-positive nociceptors in a model of inflammatory itch and pain. Brain 2014, 137: 1039-1050. PMID: 24549959, PMCID: PMC3959553, DOI: 10.1093/brain/awu007.Peer-Reviewed Original ResearchConceptsContact hypersensitivityPruriceptive neuronsEnhanced excitabilityNervous systemNociceptive dorsal root ganglion (DRG) neuronsSodium currentVehicle-treated control animalsDorsal root ganglion neuronsSquaric acid dibutyl esterItch-like behaviorsPain-related behaviorsResistant sodium currentsAllergic contact dermatitisAction potential activityWhole-cell recordingsInflammatory itchPersistent itchPruritic disordersSpontaneous itchSpontaneous scratchingAcute itchNeuronal hyperexcitabilityNociceptive neuronsPruritic diseasesCommon symptoms
1992
Subpopulations of “nocifensor neurons” contributing to pain and allodynia, itch and alloknesis
LaMotte R. Subpopulations of “nocifensor neurons” contributing to pain and allodynia, itch and alloknesis. Journal Of Pain 1992, 1: 115-126. DOI: 10.1016/1058-9139(92)90040-j.Peer-Reviewed Original ResearchSpinothalamic tract cellsDorsal hornTract cellsNociceptive primary afferent neuronsPrimary afferent neuronsPrimary sensory neuronsCentral nervous systemNon-neuronal tissuesAfferent neuronsCutaneous mechanoreceptive afferentsPrimary afferentsConvergent inputsDifferent populationsPeripheral tissuesSensory neuronsPainCutaneous injuryNervous systemMechanoreceptive afferentsNoxious eventsProlonged enhancementNeuronsItchAllodyniaAlloknesis