2017
Cl− channel is required for CXCL10-induced neuronal activation and itch response in a murine model of allergic contact dermatitis
Qu L, Fu K, Shimada SG, LaMotte RH. Cl− channel is required for CXCL10-induced neuronal activation and itch response in a murine model of allergic contact dermatitis. Journal Of Neurophysiology 2017, 118: 619-624. PMID: 28446581, PMCID: PMC5511864, DOI: 10.1152/jn.00187.2017.Peer-Reviewed Original ResearchConceptsAllergic contact dermatitisSquaric acid dibutylesterAllergic itchNeuronal activationContact hypersensitivityContact dermatitisMurine modelItch-related scratching behaviorBehavioral effectsDorsal root ganglion neuronsItch-like behaviorsPrimary sensory neuronsWhole-cell recordingsPromising therapeutic targetPersistent itchItch responseIonic mechanismsGanglion neuronsScratching behaviorChannel blockersCXCL10Sensory neuronsTherapeutic targetChannel inhibitorsCell recordings
2015
CXCR3 chemokine receptor signaling mediates itch in experimental allergic contact dermatitis
Qu L, Fu K, Yang J, Shimada SG, LaMotte RH. CXCR3 chemokine receptor signaling mediates itch in experimental allergic contact dermatitis. Pain 2015, 156: 1737-1746. PMID: 25932692, PMCID: PMC4545682, DOI: 10.1097/j.pain.0000000000000208.Peer-Reviewed Original ResearchConceptsAllergic contact dermatitisPain-like behaviorsContact hypersensitivityAllergic itchChemokine CXCL10Contact dermatitisCutaneous dorsal root ganglion neuronsPathophysiology of ACDExperimental allergic contact dermatitisDorsal root ganglion neuronsSquaric acid dibutylesterDorsal root gangliaSignificant health burdenUpregulation of CXCL10Chemokine receptor signalingCXCR3 mRNAPersistent itchSpontaneous itchInflammatory painCommon symptomsControl miceReceptor CXCR3Skin inflammationGanglion neuronsRoot ganglia
2014
Enhanced excitability of MRGPRA3- and MRGPRD-positive nociceptors in a model of inflammatory itch and pain
Qu L, Fan N, Ma C, Wang T, Han L, Fu K, Wang Y, Shimada SG, Dong X, LaMotte RH. Enhanced excitability of MRGPRA3- and MRGPRD-positive nociceptors in a model of inflammatory itch and pain. Brain 2014, 137: 1039-1050. PMID: 24549959, PMCID: PMC3959553, DOI: 10.1093/brain/awu007.Peer-Reviewed Original ResearchConceptsContact hypersensitivityPruriceptive neuronsEnhanced excitabilityNervous systemNociceptive dorsal root ganglion (DRG) neuronsSodium currentVehicle-treated control animalsDorsal root ganglion neuronsSquaric acid dibutyl esterItch-like behaviorsPain-related behaviorsResistant sodium currentsAllergic contact dermatitisAction potential activityWhole-cell recordingsInflammatory itchPersistent itchPruritic disordersSpontaneous itchSpontaneous scratchingAcute itchNeuronal hyperexcitabilityNociceptive neuronsPruritic diseasesCommon symptoms
2012
A subpopulation of nociceptors specifically linked to itch
Han L, Ma C, Liu Q, Weng HJ, Cui Y, Tang Z, Kim Y, Nie H, Qu L, Patel KN, Li Z, McNeil B, He S, Guan Y, Xiao B, LaMotte RH, Dong X. A subpopulation of nociceptors specifically linked to itch. Nature Neuroscience 2012, 16: 174-182. PMID: 23263443, PMCID: PMC3557753, DOI: 10.1038/nn.3289.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsAntirheumatic AgentsCalciumCapsaicinCells, CulturedChloroquineEpidermisGanglia, SpinalGene Expression RegulationGreen Fluorescent ProteinsHistamineHot TemperatureMaleMiceMice, Inbred C57BLMice, TransgenicMotor ActivityNerve FibersNerve Tissue ProteinsNociceptorsPain MeasurementPain ThresholdPatch-Clamp TechniquesPeptide FragmentsPlant LectinsProteinsProto-Oncogene Proteins c-fosPruritusReceptors, BombesinReceptors, G-Protein-CoupledRNA, UntranslatedRotarod Performance TestSensory Receptor CellsSensory System AgentsSpinal CordTRPV Cation ChannelsConceptsDorsal root ganglion neuronsItch-specific neuronsSubpopulation of nociceptorsGanglion neuronsNeuronsSuperficial layersMrgprA3NociceptorsItch
2006
902. Modulation of Voltage-Gated Potassium Channels in Dorsal Root Ganglion Neurons by an Inducible Adenoviral Vector In Vivo
Ma C, LaMotte R, Rosenzweig J, Gehlbach P, Johns D. 902. Modulation of Voltage-Gated Potassium Channels in Dorsal Root Ganglion Neurons by an Inducible Adenoviral Vector In Vivo. Molecular Therapy 2006, 13: s347-s348. DOI: 10.1016/j.ymthe.2006.08.991.Peer-Reviewed Original ResearchDorsal root ganglion neuronsModulation of VoltageGanglion neuronsPotassium channelsAdenoviral vectorNeurons
1999
Plasticity of sodium channel expression in DRG neurons in the chronic constriction injury model of neuropathic pain
Dib-Hajj S, Fjell J, Cummins TR, Zheng Z, Fried K, LaMotte R, Black JA, Waxman S. Plasticity of sodium channel expression in DRG neurons in the chronic constriction injury model of neuropathic pain. Pain 1999, 83: 591-600. PMID: 10568868, DOI: 10.1016/s0304-3959(99)00169-4.Peer-Reviewed Original ResearchConceptsTTX-R sodium channelsChronic constriction injury modelDRG neuronsSodium currentSodium channelsNeuropathic painInjury modelAxotomized dorsal root ganglion (DRG) neuronsSmall-diameter DRG neuronsTTX-R sodium currentsDorsal root ganglion neuronsTTX-S currentsSodium channel expressionGanglion neuronsSciatic nerveChannel expressionSodium channel transcriptsNeuronsNa currentPainChannel transcriptsSignificant changesLevels of transcriptsHyperalgesiaPrevious studies
1993
Effect of protons on the inward current evoked by capsaicin in isolated dorsal root ganglion cells
Petersen M, LaMotte R. Effect of protons on the inward current evoked by capsaicin in isolated dorsal root ganglion cells. Pain 1993, 54: 37-42. PMID: 7690929, DOI: 10.1016/0304-3959(93)90097-9.Peer-Reviewed Original ResearchConceptsInward currentsDorsal root ganglion neuronsDorsal root ganglion cellsCapsaicin-evoked currentsWhole-cell voltage-clamp conditionsImportant modulatory roleVoltage-clamp conditionsDRG cellsGanglion neuronsGanglion cellsSensory neuronsModulatory roleCapsaicinProgressive decreaseNeuronsCellsExtracellular medium
1991
Relationships between capsaicin sensitivity of mammalian sensory neurons, cell size and type of voltage gated Ca-currents
Petersen M, LaMotte R. Relationships between capsaicin sensitivity of mammalian sensory neurons, cell size and type of voltage gated Ca-currents. Brain Research 1991, 561: 20-26. PMID: 1665752, DOI: 10.1016/0006-8993(91)90744-g.Peer-Reviewed Original ResearchConceptsCapsaicin sensitivityCultured adult rat dorsal root ganglion neuronsAdult rat dorsal root ganglion neuronsLow-threshold typeRat dorsal root ganglion neuronsWhole-cell patch-clamp techniqueDorsal root ganglion neuronsCultured dorsal root gangliaCapsaicin-sensitive cellsCapsaicin-sensitive populationCross-sectional areaDorsal root gangliaMammalian sensory neuronsPatch-clamp techniqueGanglion neuronsRoot gangliaSensory neuronsCa currentCell populationsActivation thresholdLength of timeLarger cross-sectional areaSectional areaCapsaicinSmall cell population