2024
Itch and Pain Behaviors in Irritant Contact Dermatitis Produced by Sodium Lauryl Sulfate in Mice
Malewicz-Oeck N, Zhang Z, Shimada S, LaMotte R. Itch and Pain Behaviors in Irritant Contact Dermatitis Produced by Sodium Lauryl Sulfate in Mice. International Journal Of Molecular Sciences 2024, 25: 7718. PMID: 39062959, PMCID: PMC11276812, DOI: 10.3390/ijms25147718.Peer-Reviewed Original ResearchIrritant contact dermatitisDay 1Heat stimuliSkin inflammationSigns of spontaneous painContact dermatitisHyperalgesia-like behaviorResponses to pruritogensPain-like behaviorsSodium lauryl sulfateCompared to salineMeasurement of skin thicknessSpontaneous painIncreased skin thicknessHistamine-dependentPain behaviorCutaneous inflammationScratching boutsMouse modelPainSkin thicknessItchingInflammationMiceDay 0
2017
Cl− channel is required for CXCL10-induced neuronal activation and itch response in a murine model of allergic contact dermatitis
Qu L, Fu K, Shimada SG, LaMotte RH. Cl− channel is required for CXCL10-induced neuronal activation and itch response in a murine model of allergic contact dermatitis. Journal Of Neurophysiology 2017, 118: 619-624. PMID: 28446581, PMCID: PMC5511864, DOI: 10.1152/jn.00187.2017.Peer-Reviewed Original ResearchConceptsAllergic contact dermatitisSquaric acid dibutylesterAllergic itchNeuronal activationContact hypersensitivityContact dermatitisMurine modelItch-related scratching behaviorBehavioral effectsDorsal root ganglion neuronsItch-like behaviorsPrimary sensory neuronsWhole-cell recordingsPromising therapeutic targetPersistent itchItch responseIonic mechanismsGanglion neuronsScratching behaviorChannel blockersCXCL10Sensory neuronsTherapeutic targetChannel inhibitorsCell recordings
2016
Allergic Contact Dermatitis: A Model of Inflammatory Itch and Pain in Human and Mouse
LaMotte RH. Allergic Contact Dermatitis: A Model of Inflammatory Itch and Pain in Human and Mouse. Advances In Experimental Medicine And Biology 2016, 904: 23-32. PMID: 26900060, PMCID: PMC4910628, DOI: 10.1007/978-94-017-7537-3_2.Peer-Reviewed Original ResearchConceptsAllergic contact dermatitisPersistent itchPathogenesis of ACDSquaric acid dibutyl esterPain-like behaviorsSmall-diameter neuronsPeripheral neural mechanismsPossible therapeutic targetInflammatory itchPruritic disordersCutaneous sitesChemokine CXCL10Excitatory responsesLocal inflammationReceptor CXCR3Contact dermatitisUnmyelinated axonsSpontaneous activityTherapeutic targetAnimal modelsPainSubsequent challengeTopical applicationItchMice
2015
CXCR3 chemokine receptor signaling mediates itch in experimental allergic contact dermatitis
Qu L, Fu K, Yang J, Shimada SG, LaMotte RH. CXCR3 chemokine receptor signaling mediates itch in experimental allergic contact dermatitis. Pain 2015, 156: 1737-1746. PMID: 25932692, PMCID: PMC4545682, DOI: 10.1097/j.pain.0000000000000208.Peer-Reviewed Original ResearchConceptsAllergic contact dermatitisPain-like behaviorsContact hypersensitivityAllergic itchChemokine CXCL10Contact dermatitisCutaneous dorsal root ganglion neuronsPathophysiology of ACDExperimental allergic contact dermatitisDorsal root ganglion neuronsSquaric acid dibutylesterDorsal root gangliaSignificant health burdenUpregulation of CXCL10Chemokine receptor signalingCXCR3 mRNAPersistent itchSpontaneous itchInflammatory painCommon symptomsControl miceReceptor CXCR3Skin inflammationGanglion neuronsRoot gangliaPsychophysical Measurements of Itch and Nociceptive Sensations in an Experimental Model of Allergic Contact Dermatitis
Pall PS, Hurwitz OE, King BA, LaMotte RH. Psychophysical Measurements of Itch and Nociceptive Sensations in an Experimental Model of Allergic Contact Dermatitis. Journal Of Pain 2015, 16: 741-749. PMID: 26002605, PMCID: PMC4522332, DOI: 10.1016/j.jpain.2015.04.009.Peer-Reviewed Original ResearchConceptsSquaric acid dibutyl esterAllergic contact dermatitisSpontaneous itchContact dermatitisNociceptive sensationsT cell-mediated inflammationExperimental modelPeripheral neural activityQuality of lifeInflammatory itchBAM8-22Skin inflammationHypersensitivity reactionsPain sensationAllergen resultsIntradermal injectionCommon conditionHealthy volunteersPotential treatmentItchPsychophysical measurementsInflammationVolar forearmDermatitisNeural activity