1997
Children's Yale-Brown Obsessive Compulsive Scale: Reliability and Validity
Scahill L, Riddle M, McSwiggin-Hardin M, Ort S, King R, Goodman W, Cicchetti D, Leckman J. Children's Yale-Brown Obsessive Compulsive Scale: Reliability and Validity. Journal Of The American Academy Of Child & Adolescent Psychiatry 1997, 36: 844-852. PMID: 9183141, DOI: 10.1097/00004583-199706000-00023.Peer-Reviewed Original ResearchConceptsChildren's Yale-Brown Obsessive Compulsive ScaleYale-Brown Obsessive Compulsive ScaleObsessive-compulsive disorderObsessive-compulsive symptom severityManifest Anxiety ScaleObsessive-compulsive symptomsObsessive Compulsive ScaleChildren's Manifest Anxiety ScaleCompulsive ScaleCY-BOCS total scoreSymptom severityDepression InventoryChildren's Depression InventoryTotal scoreCY-BOCS scoresAnxiety ScaleConvergent validityValid subscalesInternal consistencyCompulsion scoreAdolescentsSubscalesChildrenInterrater agreementValidity
1996
A Putative Poststreptococcal Case of OCD with Chronic Tic Disorder, Not Otherwise Specified
TUCKER D, LECKMAN J, SCAHILL L, WILF G, LaCAMERA R, CARDONA L, COHEN P, HEIDMANN S, GOLDSTEIN J, JUDGE J, SNYDER E, BULT A, PETERSON B, KING R, LOMBROSO P. A Putative Poststreptococcal Case of OCD with Chronic Tic Disorder, Not Otherwise Specified. Journal Of The American Academy Of Child & Adolescent Psychiatry 1996, 35: 1684-1691. PMID: 8973076, DOI: 10.1097/00004583-199612000-00022.Peer-Reviewed Original ResearchConceptsChronic tic disorderTic disordersSelective serotonin reuptake inhibitorsSessions of plasmapheresisSerotonin reuptake inhibitorsUpper respiratory symptomsTreatment-resistant casesClinical laboratory dataCognitive behavioral therapyNeuroimmunological perspectiveProphylactic penicillinRespiratory symptomsReuptake inhibitorsObsessive-compulsive disorderConventional pharmacotherapyTreatment optionsSupportive psychotherapyFamily interventionsSeparation anxietyLaboratory dataSubsequent treatmentDisordersPsychotherapyMultiple perspectivesPharmacotherapyBehavioral Therapy in Children and Adolescents with Obsessive-Compulsive Disorder: A Pilot Study
Scahill L, Vitulano L, Brenner E, Lynch K, King R. Behavioral Therapy in Children and Adolescents with Obsessive-Compulsive Disorder: A Pilot Study. Journal Of Child And Adolescent Psychopharmacology 1996, 6: 191-202. PMID: 9231312, DOI: 10.1089/cap.1996.6.191.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderYale-Brown Obsessive Compulsive ScaleBehavioral treatmentBehavioral therapyRandomized clinical trialsTreatment of childrenChildren's Yale-Brown Obsessive Compulsive ScaleBehavioral therapy programObsessive Compulsive ScaleMedication treatmentPrimary diagnosisMonths posttreatmentClinical trialsTreatment endpointBooster sessionsDose reductionDose requirementsMedicationsUseful adjunctTherapeutic gainTreatment programTherapy programPilot studyCompulsive ScaleTreatment
1995
Childhood Trichotillomania: Clinical Phenomenology, Comorbidity, and Family Genetics
KING R, SCAHILL L, VITULANO L, SCHWAB-STONE M, TERCYAK K, RIDDLE M. Childhood Trichotillomania: Clinical Phenomenology, Comorbidity, and Family Genetics. Journal Of The American Academy Of Child & Adolescent Psychiatry 1995, 34: 1451-1459. PMID: 8543512, DOI: 10.1097/00004583-199511000-00011.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderRisperidone Treatment of Children and Adolescents with Chronic Tic Disorders: A Preliminary Report
LOMBROSO P, SCAHILL L, KING R, LYNCH K, CHAPPELL P, PETERSON B, McDOUGLE C, LECKMAN J. Risperidone Treatment of Children and Adolescents with Chronic Tic Disorders: A Preliminary Report. Journal Of The American Academy Of Child & Adolescent Psychiatry 1995, 34: 1147-1152. PMID: 7559308, DOI: 10.1097/00004583-199509000-00011.Peer-Reviewed Original ResearchConceptsChronic tic disorderTic disordersObsessive-compulsive disorderChronic motor tic disorderYale Global Tic Severity ScaleDopamine-blocking propertiesOpen-label trialFrequent side effectsEfficacy of risperidoneMotor tic disorderShort-term safetyTic Severity ScaleComorbid obsessive-compulsive disorderYale-Brown Obsessive Compulsive ScaleObsessive Compulsive ScaleClinical responseRisperidone treatmentMean ageTic scoreSeverity ScaleSide effectsTourette syndromeComorbid diagnosesTic frequencyWeight gainAn Epidemiological Study of Trichotillomania in Israeli Adolescents
KING R, ZOHAR A, RATZONI G, BINDER M, KRON S, DYCIAN A, COHEN D, PAULS D, APTER A. An Epidemiological Study of Trichotillomania in Israeli Adolescents. Journal Of The American Academy Of Child & Adolescent Psychiatry 1995, 34: 1212-1215. PMID: 7559316, DOI: 10.1097/00004583-199509000-00019.Peer-Reviewed Original ResearchConceptsObsessive-compulsive symptomsComorbid psychopathologyPrevalence of trichotillomaniaSignificant obsessive-compulsive symptomsObsessive-compulsive disorderLifetime prevalenceVocal ticsComorbid disordersEpidemiological studiesPrevalenceAnxiety disordersPhysical fitnessSubsequent reliefTrichotillomaniaCommunity adolescent sampleDisordersSymptomsElevated ratesOverall competencySubjectsAdolescentsReliefPsychopathologyBald spotsIsraeli adolescents
1994
Fluvoxamine Open-Label Treatment of Adolescent Inpatients with Obsessive-Compulsive Disorder or Depression
APTER A, RATZONI G, KING R, WEIZMAN A, IANCU I, BINDER M, RIDDLE M. Fluvoxamine Open-Label Treatment of Adolescent Inpatients with Obsessive-Compulsive Disorder or Depression. Journal Of The American Academy Of Child & Adolescent Psychiatry 1994, 33: 342-348. PMID: 8169178, DOI: 10.1097/00004583-199403000-00007.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderMajor depressive disorderYale-Brown Obsessive Compulsive ScaleOvert Aggression ScaleBeck Depression InventorySide effectsSuicide Potential ScaleSpecific serotonin uptake inhibitorAdolescent inpatientsEfficacy of fluvoxamineOpen-label trialOpen-label treatmentCommon side effectsSerotonin uptake inhibitorSerious side effectsShort-term treatmentY-BOCS scoresObsessive Compulsive ScaleDaily dosesTarget symptomsDepressive disorderDemonstrated efficacyInvestigational basisUptake inhibitorFluvoxamine
1992
Double-Blind, Crossover Trial of Fluoxetine and Placebo in Children and Adolescents with Obsessive-Compulsive Disorder
RIDDLE M, SCAHILL L, KING R, HARDIN M, ANDERSON G, ORT S, SMITH J, LECKMAN J, COHEN D. Double-Blind, Crossover Trial of Fluoxetine and Placebo in Children and Adolescents with Obsessive-Compulsive Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 1992, 31: 1062-1069. PMID: 1429406, DOI: 10.1097/00004583-199211000-00011.Peer-Reviewed Original ResearchConceptsChildren's Yale-Brown Obsessive Compulsive ScaleObsessive-compulsive disorderYale-Brown Obsessive Compulsive ScaleEffective short-term treatmentSafety of fluoxetineFixed-dose trialCommon drug side effectsCY-BOCS total scoreMajor depressive disorderShort-term treatmentDrug side effectsMagnitude of improvementObsessive Compulsive ScaleFluoxetine groupPlacebo groupFluoxetine treatmentCrossover trialClinical trialsDepressive disorderObsessive-compulsive symptom severitySide effectsFluoxetineSymptom severityTotal scoreCompulsive Scale
1991
Emergence of Self-Destructive Phenomena in Children and Adolescents during Fluoxetine Treatment
KING R, RIDDLE M, CHAPPELL P, HARDIN M, ANDERSON G, LOMBROSO P, SCAHILL L. Emergence of Self-Destructive Phenomena in Children and Adolescents during Fluoxetine Treatment. Journal Of The American Academy Of Child & Adolescent Psychiatry 1991, 30: 179-186. PMID: 2016219, DOI: 10.1097/00004583-199103000-00003.Peer-Reviewed Original ResearchConceptsFluoxetine treatmentObsessive-compulsive disorderUniversity Clinical Research CenterClinical Research CenterMajor risk factorDrug-induced activationPrior suicidal ideationYounger patientsRisk factorsRegulation of aggressionPatientsSuicidal ideationSelf-destructive behaviorFluoxetineAge 10Apparent associationVulnerable individualsDisordersTreatmentIdeationDe novoHospitalizationSymptoms
1990
Obsessive Compulsive Disorder in Children and Adolescents: Phenomenology and Family History
RIDDLE M, SCAHILL L, KING R, HARDIN M, TOWBIN K, ORT S, LECKMAN J, COHEN D. Obsessive Compulsive Disorder in Children and Adolescents: Phenomenology and Family History. Journal Of The American Academy Of Child & Adolescent Psychiatry 1990, 29: 766-772. PMID: 2228931, DOI: 10.1097/00004583-199009000-00015.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderCompulsive disorderDisorder diagnosisAnxiety disorder diagnosisObsessive-compulsive symptomsClinical psychiatric assessmentMood disorder diagnosisAssociated psychopathologyContamination concernsResearch implicationsAdolescentsPsychiatric assessmentChildrenDisordersFamily membersPsychopathologyPhenomenologyParentsSymptomsImplicationsFindingsFamily historyBehaviorFluoxetine Treatment of Children and Adolescents with Tourette's and Obsessive Compulsive Disorders: Preliminary Clinical Experience
RIDDLE M, HARDIN M, KING R, SCAHILL L, WOOLSTON J. Fluoxetine Treatment of Children and Adolescents with Tourette's and Obsessive Compulsive Disorders: Preliminary Clinical Experience. Journal Of The American Academy Of Child & Adolescent Psychiatry 1990, 29: 45-48. PMID: 2295577, DOI: 10.1097/00004583-199001000-00008.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderPreliminary clinical experiencePrimary obsessive-compulsive disorderTourette syndromeClinical experienceSelective serotonin uptake inhibitorMild gastrointestinal symptomsSerotonin uptake inhibitorEfficacy of fluoxetineCompulsive disorderFluoxetine administrationGastrointestinal symptomsFluoxetine treatmentResponder rateUptake inhibitorFluoxetineObsessive-compulsive symptomsPatientsAdverse effectsFluoxetine hydrochlorideSyndromeChildrenSymptomsOCD groupAdolescents