2014
The spatial and signal characteristics of physiologic high frequency oscillations
Alkawadri R, Gaspard N, Goncharova II, Spencer DD, Gerrard JL, Zaveri H, Duckrow RB, Blumenfeld H, Hirsch LJ. The spatial and signal characteristics of physiologic high frequency oscillations. Epilepsia 2014, 55: 1986-1995. PMID: 25470216, PMCID: PMC5123742, DOI: 10.1111/epi.12851.Peer-Reviewed Original ResearchConceptsPhysiologic high-frequency oscillationsSeizure onsetEpileptic networkNon-rapid eye movement sleepComprehensive Epilepsy CenterMesial temporal structuresEye movement sleepHigh-frequency oscillationsHighest HFO ratesFirst seizureInvasive evaluationEpilepsy centersIntracranial evaluationMovement sleepPerirolandic regionEpileptiform dischargesParietooccipital regionOccipital lobeEpileptic sitesPatientsNonepileptic regionsPhysiologic eventsFast ripplesHFO ratesLonger durationSubclinical seizures during intracranial EEG recording: Are they clinically significant?
Farooque P, Duckrow R. Subclinical seizures during intracranial EEG recording: Are they clinically significant? Epilepsy Research 2014, 108: 1790-1796. PMID: 25306063, DOI: 10.1016/j.eplepsyres.2014.09.020.Peer-Reviewed Original ResearchConceptsPoor surgical outcomesGood surgical outcomeSubclinical seizuresSurgical outcomesClinical seizuresIntracranial EEG recordingsGroup 2Group 1Extra-temporal lobe epilepsySeizure onset regionEEG recordingsExtra-temporal originResection correlatesSurgical resectionLobe epilepsyPoor outcomePrognostic valueClinical significanceBetter outcomesPatientsSeizuresEpileptic networkOnset zoneDifferent anatomical regionsEpilepsy database
2012
Metabolic networks in epilepsy by MR spectroscopic imaging
Pan JW, Spencer DD, Kuzniecky R, Duckrow RB, Hetherington H, Spencer SS. Metabolic networks in epilepsy by MR spectroscopic imaging. Acta Neurologica Scandinavica 2012, 126: 411-420. PMID: 22574807, PMCID: PMC3600585, DOI: 10.1111/j.1600-0404.2012.01665.x.Peer-Reviewed Original ResearchConceptsMTLE patientsBasal gangliaEpileptic networkMesial temporal lobe epilepsy patientsTemporal lobe epilepsy patientsLimbic seizure propagationBilateral basal gangliaNAA/CrMR spectroscopicIpsilateral insulaSeizure propagationBilateral hippocampusEpilepsy patientsHuman studiesIndependent factorsPatientsNeuronal functionThalamusGangliaEpilepsyInsulaFactor analysisFactorsHippocampusInjury