2001
Cholinergic stimulation of rat acinar cells increases c-fos and c-jun expression via a mitogen-activated protein kinase-dependent pathway
Turner DJ, Cowles RA, Segura BJ, Mulholland MW. Cholinergic stimulation of rat acinar cells increases c-fos and c-jun expression via a mitogen-activated protein kinase-dependent pathway. Journal Of Gastrointestinal Surgery 2001, 5: 661-672. PMID: 12086906, DOI: 10.1016/s1091-255x(01)80110-4.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceBlotting, WesternCalciumCalcium SignalingCarbacholCells, CulturedCholinergic AgonistsDiaminesDose-Response Relationship, DrugEnzyme ActivationGene ExpressionMolecular Sequence DataPancreasPiperidinesPirenzepinePolymerase Chain ReactionProto-Oncogene Proteins c-fosProto-Oncogene Proteins c-junRatsReceptors, MuscarinicSensitivity and SpecificityConceptsC-jun early response geneMitogen-activated protein kinase activityProtein kinase-dependent pathwayMitogen-activated protein kinase-dependent pathwayProtein kinase activityAR42J acinar cellsEarly response genesKinase-dependent pathwayDose-dependent increaseC-fosAcetylcholine analogue carbacholC-jun expressionAcinar cellsKinase activityGene expressionM2 inhibitionRat acinar cellsMuscarinic receptor subtypes M1Enzyme activationSpecific inhibitorM3 receptor subtypePolymerase chain reaction analysisChain reaction analysisPancreatic exocrine functionIntracellular calcium release
2000
Cholinergic intrapancreatic neurons induce Ca2+ signaling and early-response gene expression in pancreatic acinar cells
Turner D, Cowles R, Segura B, Romanchuk G, Barnhart D, Mulholland M. Cholinergic intrapancreatic neurons induce Ca2+ signaling and early-response gene expression in pancreatic acinar cells. Journal Of Gastrointestinal Surgery 2000, 4: 475-480. PMID: 11077322, DOI: 10.1016/s1091-255x(00)80089-x.Peer-Reviewed Original ResearchConceptsPancreatic acinar cellsC-fos expressionIntrapancreatic neuronsAcinar cellsEarly response gene expressionPancreatic exocrine functionIntracellular calcium levelsC-Fos proteinAR42J pancreatic acinar cellsExocrine functionCholinergic stimulationNeuronal depolarizationIntracellular calciumLong-term consequencesCalcium levelsNeuronal regulationNeuronsGene expressionPancreatic lobulesCalcium signalingCellsDepolarizationExpressionAverage increaseAgonists