2022
Association Between Antibiotic Redosing Before Incision and Risk of Incisional Site Infection in Children With Appendicitis
Cramm S, Chandler N, Graham D, Kunisaki S, Russell R, Blakely M, Lipskar A, Allukian M, Aronowitz D, Campbell B, Collins D, Commander S, Cowles R, DeFazio J, Esparaz J, Feng C, Griggs C, Guyer R, Hanna D, Kahan A, Keane O, Lamoshi A, Lopez C, Pace E, Regan M, Santore M, Scholz S, Tracy E, Williams S, Zhang L, Rangel S. Association Between Antibiotic Redosing Before Incision and Risk of Incisional Site Infection in Children With Appendicitis. Annals Of Surgery 2022, 278: e863-e869. PMID: 36317528, DOI: 10.1097/sla.0000000000005747.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsAppendectomyAppendicitisCefoxitinChildHumansRetrospective StudiesSurgical Wound InfectionTreatment OutcomeConceptsIncisional surgical site infectionHour of incisionPediatric National Surgical Quality Improvement ProgramNational Surgical Quality Improvement ProgramSurgical Quality Improvement ProgramSite infectionQuality Improvement ProgramAntibiotic redosingIncisional surgical site infection rateMulticenter retrospective cohort studyDisease severityDiagnosis of appendicitisSurgical site infectionRetrospective cohort studyRedosing of antibioticsOperative report dataMultivariate logistic regressionHospital-level clusteringIncreased disease severityAntibiotic regimensInitial doseAntibiotic administrationPatient demographicsAntibiotic utilizationChart reviewAssociation of Gangrenous, Suppurative, and Exudative Findings With Outcomes and Resource Utilization in Children With Nonperforated Appendicitis
Cramm SL, Lipskar AM, Graham DA, Kunisaki SM, Griggs CL, Allukian M, Russell RT, Chandler NM, Santore MT, Aronowitz DI, Blakely ML, Campbell B, Collins DT, Commander SJ, Cowles RA, DeFazio JR, Echols JC, Esparaz JR, Feng C, Guyer RA, Hanna DN, He K, Kahan AM, Keane OA, Lamoshi A, Lopez CM, McLean SE, Pace E, Regan MD, Scholz S, Tracy ET, Williams SA, Zhang L, Rangel SJ, Chang A, Fitzgerald M, Middlesworth W, Finck C, Hackam D, Engwall-Gill A, Gerall C, Orlas C, Hwang R, Dantes G. Association of Gangrenous, Suppurative, and Exudative Findings With Outcomes and Resource Utilization in Children With Nonperforated Appendicitis. JAMA Surgery 2022, 157: 685-692. PMID: 35648410, PMCID: PMC9161124, DOI: 10.1001/jamasurg.2022.1928.Peer-Reviewed Original ResearchMeSH KeywordsAppendectomyAppendicitisChildCohort StudiesGangreneHumansLength of StayRetrospective StudiesSuppurationSurgical Wound InfectionTreatment OutcomeConceptsSurgical site infectionSite infectionExudative findingsPostoperative lengthOperative reportsNonperforated appendicitisNational Surgical Quality Improvement ProgramMultivariable mixed-effects regressionPostoperative surgical site infectionSurgical Quality Improvement ProgramPediatric National Surgical Quality Improvement ProgramMean postoperative lengthOrgan space infectionMulticenter cohort studyMedical record reviewCohort of childrenQuality Improvement ProgramPostoperative antibioticsCohort studyInpatient managementPatient characteristicsSecondary outcomesSpace infectionPrimary outcomeHospital revisitsIndex Admission Cholecystectomy and Recurrence of Pediatric Gallstone Pancreatitis: Multicenter Cohort Analysis.
Muñoz Abraham AS, Osei H, Bajinting A, Cowles RA, Greenspon J, Hosfield BD, Keller MS, Landman MP, Owens H, Shaughnessy MP, St Peter SD, Sujka J, Vogel AM, Villalona GA. Index Admission Cholecystectomy and Recurrence of Pediatric Gallstone Pancreatitis: Multicenter Cohort Analysis. Journal Of The American College Of Surgeons 2022, 234: 352-358. PMID: 35213498, DOI: 10.1097/xcs.0000000000000062.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChildCholecystectomyFemaleGallstonesHospitalizationHumansMalePancreatitisRecurrenceRetrospective StudiesConceptsGallstone pancreatitisEarly cholecystectomyIndex admissionRecurrent pancreatitisRecurrence rateMean body mass indexIndex admission cholecystectomyMean age 13.5Multicenter cohort analysisTiming of cholecystectomyBody mass indexBiliary complicationsInterval cholecystectomyIndex dischargeCholecystectomy ratesGroup patientsMost patientsLaboratory characteristicsMild pancreatitisPediatric patientsRetrospective reviewMass indexCholecystectomyCohort analysisPancreatitis
2021
Reducing Underdiagnosis of Hirschsprung-Associated Enterocolitis: A Novel Scoring System
Lewit RA, Veras LV, Cowles RA, Fowler K, King S, Lapidus-Krol E, Langer JC, Park CJ, Youssef F, Vavilov S, Gosain A. Reducing Underdiagnosis of Hirschsprung-Associated Enterocolitis: A Novel Scoring System. Journal Of Surgical Research 2021, 261: 253-260. PMID: 33460971, PMCID: PMC8166452, DOI: 10.1016/j.jss.2020.12.030.Peer-Reviewed Original ResearchMeSH KeywordsEnterocolitisFemaleHirschsprung DiseaseHumansIncidenceInfantMaleRetrospective StudiesSeverity of Illness IndexConceptsHirschsprung-associated enterocolitisNew scoring systemSensitivity/specificityScoring systemHirschsprung's diseaseMultivariate analysisPercent of patientsReceipt of treatmentStepwise multivariate analysisProspective data collectionNovel scoring systemHAEC episodesRectal irrigationBowel restSignificant underdiagnosisRadiographic findingsPatient cohortColonic diseaseMore episodesUnivariate analysisHigh riskDiagnostic cutoffHead comparisonClinical settingLogistic regression
2020
Outcomes following adoption of a standardized protocol for abscess drain management in pediatric appendicitis
Eysenbach LM, Caty MG, Christison-Lagay ER, Cowles RA, Dillon B, Goodman TR, Ozgediz DE, Stitelman DH, Solomon DG. Outcomes following adoption of a standardized protocol for abscess drain management in pediatric appendicitis. Journal Of Pediatric Surgery 2020, 56: 43-46. PMID: 33143877, DOI: 10.1016/j.jpedsurg.2020.09.050.Peer-Reviewed Original ResearchConceptsPediatric appendicitisClinical outcomesStandardized protocolImaging studiesTertiary care children's hospitalEvidence-based clinical pathwayAlternative imaging studyIR proceduresManagement of abscessesRetrospective chart reviewCases of appendicitisPercutaneous abscess drainageInterventional radiologic proceduresDiagnostic imaging studiesComplicated appendicitisBaseline demographicsChart reviewClinical factorsAbscess drainageClinical presentationDrain outputChildren's HospitalDrain daysClinical pathwayAnesthetic administration
2018
Surgical modifications of the Kasai hepatoportoenterostomy minimize invasiveness without compromising short- and medium-term outcomes
Park CJ, Armenia SJ, Keung CH, Compton JT, Cowles RA. Surgical modifications of the Kasai hepatoportoenterostomy minimize invasiveness without compromising short- and medium-term outcomes. Journal Of Pediatric Surgery 2018, 54: 537-542. PMID: 30041859, DOI: 10.1016/j.jpedsurg.2018.06.028.Peer-Reviewed Original ResearchMeSH KeywordsBiliary AtresiaFemaleHumansInfantInfant, NewbornIntestinesLiverLiver TransplantationMalePortoenterostomy, HepaticRetrospective StudiesSurvival AnalysisConceptsKasai hepatoportoenterostomyBiliary atresiaLiver transplantLiver transplant proceduresNative liver survivalEffective surgical therapyMedium-term outcomesYears of ageLiver survivalLiver dysfunctionOverall survivalSurgical therapyLiver failureBile stasisMedian timeProgressive fibrosisBile drainageTransplant proceduresMean ageBiliary treeSingle institutionPatient outcomesPortal plateSurgical modificationsAbdominal cavity