Butyrate and the Intestinal Epithelium: Modulation of Proliferation and Inflammation in Homeostasis and Disease
Salvi PS, Cowles RA. Butyrate and the Intestinal Epithelium: Modulation of Proliferation and Inflammation in Homeostasis and Disease. Cells 2021, 10: 1775. PMID: 34359944, PMCID: PMC8304699, DOI: 10.3390/cells10071775.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAnti-proliferative effectsIntestinal stem cellsTolerogenic dendritic cellsAnti-inflammatory cytokinesEpithelial cellsInflammatory bowel diseaseMicrobial metabolite butyrateStem cellsApparent protective effectButyrate-producing bacteriaCellular fuelRole of butyrateCrypt base stem cellsModulation of proliferationButyrate paradoxMalabsorptive statesBowel diseaseDendritic cellsEpithelial inflammationColonic neoplasiaIntestinal microbiomeProtective effectIntestinal neoplasiaIntestinal lumenEpithelial proliferationSerotonin as a Mitogen in the Gastrointestinal Tract: Revisiting a Familiar Molecule in a New Role
Shah PA, Park CJ, Shaughnessy MP, Cowles RA. Serotonin as a Mitogen in the Gastrointestinal Tract: Revisiting a Familiar Molecule in a New Role. Cellular And Molecular Gastroenterology And Hepatology 2021, 12: 1093-1104. PMID: 34022423, PMCID: PMC8350061, DOI: 10.1016/j.jcmgh.2021.05.008.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsEnteric nervous systemSerotonin receptorsGI tractPotentiation of serotoninInflammatory bowel diseaseVascular smooth muscleIntestinal epithelial proliferationIntestinal crypt cellsBody's serotoninMalabsorptive conditionsIntestinal injuryEnteric neuronsIntestinal motilityBowel diseaseIntestinal inflammationEnterochromaffin cellsGI diseaseSerotonergic neuronsMuscarinic receptorsCholinergic signalingSerotonin synthesisGastrointestinal systemGastrointestinal tractIntestinal mucosaSmooth muscle