2022
Short Bowel Syndrome and Intestinal Lengthening Procedures
Salvi P, Cowles R. Short Bowel Syndrome and Intestinal Lengthening Procedures. 2022, 345-356. DOI: 10.1007/978-3-030-96542-6_31.ChaptersIntestinal lengthening proceduresParenteral nutritionLengthening proceduresIntestinal transplantSurgical interventionMultidisciplinary intestinal rehabilitation programParenteral nutrition failureIntestinal rehabilitation programShort bowel syndromeSmall bowel resectionSignificant physiologic consequencesCompensatory-adaptive changesBowel functionBowel resectionBowel syndromeIntestinal transitIntestinal adaptationIntestinal lossSpecialized epithelial cellsMucosal growthRehabilitation programPhysiologic consequencesDistal ileumPatientsFat absorption
2016
Enhanced serotonin signaling increases intestinal neuroplasticity
Greig CJ, Gandotra N, Tackett JJ, Bamdad MC, Cowles RA. Enhanced serotonin signaling increases intestinal neuroplasticity. Journal Of Surgical Research 2016, 206: 151-158. PMID: 27916355, DOI: 10.1016/j.jss.2016.07.021.Peer-Reviewed Original ResearchConceptsSelective serotonin reuptake inhibitorsIntestinal mucosal growthSERT knockoutMucosal growthEnterocyte proliferationEnteric nervous systemSerotonin reuptake inhibitorsMassive bowel resectionSerotonin reuptake transporterAge-matched WTGAP-43 expressionWild-type miceSynthesis inhibitionMarkers of neuroplasticityImportant regulatorReversal of effectsEpithelial cell compartmentWestern blot analysisBowel resectionReuptake inhibitorsWT miceReuptake transporterMucosal homeostasisIntestinal segmentsCrypt depth