2022
Metabolic Alkalosis
Krishnan N, Alpern R. Metabolic Alkalosis. Nephrology Self-Assessment Program 2022, 20: 145-159. DOI: 10.1681/nsap.2022.20.2.6.Peer-Reviewed Original Research
2018
Use of Renin Angiotensin System Blockers After Acute Kidney Injury: Balancing Tradeoffs.
Alpern RJ, Peixoto AJ. Use of Renin Angiotensin System Blockers After Acute Kidney Injury: Balancing Tradeoffs. JAMA Internal Medicine 2018, 178: 1690-1692. PMID: 30422208, DOI: 10.1001/jamainternmed.2018.4757.Peer-Reviewed Original ResearchDonald Seldin: A Transformative Leader in Medicine and Nephrology
Alpern R, Giebisch G. Donald Seldin: A Transformative Leader in Medicine and Nephrology. Journal Of The American Society Of Nephrology 2018, 29: 2029-2030. PMID: 29986871, PMCID: PMC6065072, DOI: 10.1681/asn.2018060603.Peer-Reviewed Original ResearchAcid Stimulation of the Citrate Transporter NaDC-1 Requires Pyk2 and ERK1/2 Signaling Pathways
Zacchia M, Tian X, Zona E, Alpern RJ, Preisig PA. Acid Stimulation of the Citrate Transporter NaDC-1 Requires Pyk2 and ERK1/2 Signaling Pathways. Journal Of The American Society Of Nephrology 2018, 29: 1720-1730. PMID: 29678998, PMCID: PMC6054333, DOI: 10.1681/asn.2017121268.Peer-Reviewed Original ResearchMeSH KeywordsAcidsAmmonium ChlorideAnimalsCells, CulturedCitric AcidCSK Tyrosine-Protein KinaseDicarboxylic Acid TransportersEndothelin-1Epithelial CellsFocal Adhesion Kinase 2Kidney Tubules, ProximalMAP Kinase Signaling SystemMiceMice, KnockoutMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3OpossumsOrganic Anion Transporters, Sodium-DependentPhosphorylationProto-Oncogene Proteins c-rafReceptor, Endothelin BRibosomal Protein S6 Kinases, 90-kDaSrc-Family KinasesTransfectionConceptsET-1/ETEndothelin-1Proximal tubulesCultured opossum kidney cellsAcid stimulationInhibition of Pyk2ET-1 stimulationRenal proximal tubulesNaDC-1Opossum kidney cellsCl loadingC-SrcPhosphorylation of Raf1Urine citratePyk2 knockdownEnd pointAcid loadApical NaERK1/2 pathwayStimulationMiceKidney cellsKidneyPyk2ERK1/2
2017
Randomized, Controlled Trial of TRC101 to Increase Serum Bicarbonate in Patients with CKD
Bushinsky DA, Hostetter T, Klaerner G, Stasiv Y, Lockey C, McNulty S, Lee A, Parsell D, Mathur V, Li E, Buysse J, Alpern R. Randomized, Controlled Trial of TRC101 to Increase Serum Bicarbonate in Patients with CKD. Clinical Journal Of The American Society Of Nephrology 2017, 13: 26-35. PMID: 29102959, PMCID: PMC5753317, DOI: 10.2215/cjn.07300717.Peer-Reviewed Original ResearchConceptsSerum bicarbonateEnd of treatmentMetabolic acidosisTreatment groupsBaseline serum bicarbonateMean baseline eGFRMEq/LSignificant adverse effectsBaseline eGFRGastrointestinal eventsAdverse eventsFirst doseControlled TrialsHeart failurePatientsCKDBaseline levelsMean increaseAbstractTextUnit studiesAcidosisAdverse effectsPlaceboTreatmentDays
2015
Research in academic medical centers: Two threats to sustainable support
Levine AS, Alpern RJ, Andrews NC, Antman K, Balser JR, Berg JM, Davis PB, Fitz JG, Golden RN, Goldman L, Jameson JL, Lee VS, Polonsky KS, Rappley MD, Reece EA, Rothman PB, Schwinn DA, Shapiro LJ, Spiegel AM. Research in academic medical centers: Two threats to sustainable support. Science Translational Medicine 2015, 7: 289fs22-289fs22. PMID: 26019216, DOI: 10.1126/scitranslmed.aac5200.Peer-Reviewed Original Research
2013
Treatment of Severe Metabolic Alkalosis in a Patient With Congestive Heart Failure
Peixoto AJ, Alpern RJ. Treatment of Severe Metabolic Alkalosis in a Patient With Congestive Heart Failure. American Journal Of Kidney Diseases 2013, 61: 822-827. PMID: 23481366, DOI: 10.1053/j.ajkd.2012.10.028.Peer-Reviewed Original ResearchConceptsCongestive heart failureHeart failureMetabolic alkalosisLow bicarbonate dialysisRenal bicarbonate excretionRenin-angiotensin systemSevere metabolic alkalosisDistal sodium deliveryCommon acid-base disorderAcid-base disordersDiuretic regimenDiuretic therapyAldosterone antagonistsNeurohormonal activationCirculatory failureBicarbonate excretionKidney failurePotassium repletionSodium deliveryBase excessUrine acidificationAppropriate managementAlkalosisDisease statesBicarbonate retentionChapter 38 Pathophysiology of Sodium Retention and Wastage
Palmer B, Alpern R, Seldin D. Chapter 38 Pathophysiology of Sodium Retention and Wastage. 2013, 1283-1317. DOI: 10.1016/b978-0-12-381462-3.00038-0.Peer-Reviewed Original ResearchChapter 58 Clinical Syndromes of Metabolic Alkalosis
Moe O, Alpern R, Seldin D. Chapter 58 Clinical Syndromes of Metabolic Alkalosis. 2013, 2021-2047. DOI: 10.1016/b978-0-12-381462-3.00058-6.Peer-Reviewed Original ResearchChapter 59 Clinical Syndromes of Metabolic Acidosis
Krapf R, Seldin D, Alpern R. Chapter 59 Clinical Syndromes of Metabolic Acidosis. 2013, 2049-2111. DOI: 10.1016/b978-0-12-381462-3.00059-8.Peer-Reviewed Original ResearchMetabolic acidosisDivalent ion metabolismMaladaptive renal responseUrine anion gapAcute metabolic acidosisNegative nitrogen balanceAcid-base disturbancesBlood buffer capacitySecondary hypocapniaClinical sequelaeRenal responseChronic settingClinical syndromeVentilatory responseBone metabolismBone massAnion gapPrimary decreaseSevere formDiagnostic criteriaBone qualitySecondary decreaseAcidosisElectrolyte changesClinical settingChapter 55 Cellular Mechanisms of Renal Tubular Acidification
Hamm L, Alpern R, Preisig P. Chapter 55 Cellular Mechanisms of Renal Tubular Acidification. 2013, 1917-1978. DOI: 10.1016/b978-0-12-381462-3.00055-0.Chapters
2011
Competencies in Premedical and Medical Education: The AAMC–HHMI Report
Alpern RJ, Belitsky R, Long S. Competencies in Premedical and Medical Education: The AAMC–HHMI Report. Perspectives In Biology And Medicine 2011, 54: 30-35. PMID: 21399381, DOI: 10.1353/pbm.2011.0001.Peer-Reviewed Original ResearchConceptsScience educationPremedical curriculumMedical educationSchool science curriculumAmerican Medical CollegesMedical school admissionsHoward Hughes Medical InstituteImportance of scienceScience curriculumMedical curriculumCourse requirementsMedical studentsSchool admissionsCurriculumNumber of recommendationsEducationBiological sciencesScientific knowledge basePhysical sciencesPractice of medicineStudentsCompetenciesMedical CollegeScienceKnowledge baseDefining hypercalciuria in nephrolithiasis
Pak CY, Sakhaee K, Moe OW, Poindexter J, Adams-Huet B, Pearle MS, Zerwekh JE, Preminger GM, Wills MR, Breslau NA, Bartter FC, Brater DC, Heller HJ, Odvina CV, Wabner CL, Fordtran JS, Oh M, Garg A, Harvey JA, Alpern RJ, Snyder WH, Peters PC. Defining hypercalciuria in nephrolithiasis. Kidney International 2011, 80: 777-782. PMID: 21775970, PMCID: PMC4354881, DOI: 10.1038/ki.2011.227.Peer-Reviewed Original ResearchConceptsAbsorptive hypercalciuria type IUrinary calcium excretionMean urinary calciumCalcium excretionUrinary calciumStone formersUpper normal limitKidney stone formersType IOptimal cutoff pointNon-stone formersCharacteristic curve analysisAbsorptive hypercalciuriaRetrospective studyNormal limitsDietary variablesHypercalciuriaCutoff pointDietary influencesNormal individualsPatientsCurve analysisExcretionConstant dietDiet
2010
Pre-medical education for future physicians: evolution at Yale and beyond.
Segraves W, Alpern R, Salovey P. Pre-medical education for future physicians: evolution at Yale and beyond. Connecticut Medicine 2010, 74: 529-32. PMID: 21073011.Peer-Reviewed Original ResearchAcid regulation of NaDC-1 requires a functional endothelin B receptor
Liu L, Zacchia M, Tian X, Wan L, Sakamoto A, Yanagisawa M, Alpern RJ, Preisig PA. Acid regulation of NaDC-1 requires a functional endothelin B receptor. Kidney International 2010, 78: 895-904. PMID: 20703215, DOI: 10.1038/ki.2010.264.Peer-Reviewed Original ResearchMeSH KeywordsAcidosisAnimalsBiological TransportCell LineDicarboxylic Acid TransportersDisease Models, AnimalEndothelin B Receptor AntagonistsEndothelin-1Hydrogen-Ion ConcentrationKidneyMiceMice, KnockoutMicrovilliOligopeptidesOpossumsOrganic Anion Transporters, Sodium-DependentPiperidinesProtein Structure, TertiaryReceptor, Endothelin AReceptor, Endothelin BRecombinant Fusion ProteinsSignal TransductionSymportersTime FactorsTransfectionConceptsEndothelin-1Endothelin-B receptor antagonistFunctional endothelin B receptorsStimulatory effectAcid-stimulatory effectET-1 effectsB receptor antagonistNHE3 activityEndothelin B receptorWild-type miceET-1 stimulationMajor physiological stimulusNaDC-1Acid ingestionReceptor antagonistCitrate reabsorptionReceptor expressionCitrate excretionOpossum kidneyAcid loadB receptorAcid feedingPhysiological stimuliStimulationMice招請講演3: Dietary Acid, Pyk2, Nocturnin, and Circadian Rhythm: Role in Renal Homeostasis and Disease
Preisig P, Alpern R. 招請講演3: Dietary Acid, Pyk2, Nocturnin, and Circadian Rhythm: Role in Renal Homeostasis and Disease. 日本腎臓学会誌 2010, 48: 145-145. DOI: 10.14842/jpnjnephrol1959.48.3_145.Peer-Reviewed Original Research
2009
Medical Report's Static Charge Sparks Shock—Response
Alpern R, Long S. Medical Report's Static Charge Sparks Shock—Response. Science 2009, 326: 1481-1482. DOI: 10.1126/science.326.5959.1481-b.Peer-Reviewed Original ResearchAn academic, apolitical approach to health care reform.
Alpern R. An academic, apolitical approach to health care reform. The Journal Of Clinical Investigation 2009, 119: 2853-4. PMID: 20069711, PMCID: PMC2752101, DOI: 10.1172/jci40997.Peer-Reviewed Original ResearchScience for Future Physicians
Long S, Alpern R. Science for Future Physicians. Science 2009, 324: 1241-1241. PMID: 19498132, DOI: 10.1126/science.1176994.Peer-Reviewed Original Research
2008
CHAPTER 36 Physiology and Pathophysiology of Sodium Retention and Wastage
Palmer B, Alpern R, Seldin D. CHAPTER 36 Physiology and Pathophysiology of Sodium Retention and Wastage. 2008, 1005-1049. DOI: 10.1016/b978-012088488-9.50039-5.Peer-Reviewed Original Research