2011
Defining hypercalciuria in nephrolithiasis
Pak CY, Sakhaee K, Moe OW, Poindexter J, Adams-Huet B, Pearle MS, Zerwekh JE, Preminger GM, Wills MR, Breslau NA, Bartter FC, Brater DC, Heller HJ, Odvina CV, Wabner CL, Fordtran JS, Oh M, Garg A, Harvey JA, Alpern RJ, Snyder WH, Peters PC. Defining hypercalciuria in nephrolithiasis. Kidney International 2011, 80: 777-782. PMID: 21775970, PMCID: PMC4354881, DOI: 10.1038/ki.2011.227.Peer-Reviewed Original ResearchConceptsAbsorptive hypercalciuria type IUrinary calcium excretionMean urinary calciumCalcium excretionUrinary calciumStone formersUpper normal limitKidney stone formersType IOptimal cutoff pointNon-stone formersCharacteristic curve analysisAbsorptive hypercalciuriaRetrospective studyNormal limitsDietary variablesHypercalciuriaCutoff pointDietary influencesNormal individualsPatientsCurve analysisExcretionConstant dietDiet
1997
Does hyperphosphaturla underlle hypercalciuria?
Alpern R, Sakhaee K. Does hyperphosphaturla underlle hypercalciuria? The Lancet 1997, 349: 518-519. PMID: 9048785, DOI: 10.1016/s0140-6736(97)80080-3.Peer-Reviewed Original Research
1996
Endothelin(B) receptor activates NHE-3 by a Ca2+-dependent pathway in OKP cells.
Chu TS, Peng Y, Cano A, Yanagisawa M, Alpern RJ. Endothelin(B) receptor activates NHE-3 by a Ca2+-dependent pathway in OKP cells. Journal Of Clinical Investigation 1996, 97: 1454-1462. PMID: 8617878, PMCID: PMC507205, DOI: 10.1172/jci118567.Peer-Reviewed Original ResearchConceptsNa/H antiporter activityReceptor blockersET-1OKP cellsET-1-induced increaseEndothelin receptor blockersNHE-3Pertussis toxin pretreatmentSelective receptor blockerAntiporter activationM endothelinPertussis toxinToxin pretreatmentSustained increaseAntiporter isoformsEndothelinTransient increaseAntiporter activityBlockersKinase inhibitorsCyclic GMPAdenylyl cyclaseReceptor cDNADependent pathwayReceptors
1991
Inhibition of Na(+)-independent H+ pump by Na(+)-induced changes in cell Ca2+.
Hays SR, Alpern RJ. Inhibition of Na(+)-independent H+ pump by Na(+)-induced changes in cell Ca2+. The Journal Of General Physiology 1991, 98: 791-813. PMID: 1660062, PMCID: PMC2229082, DOI: 10.1085/jgp.98.4.791.Peer-Reviewed Original ResearchConceptsCell pH recoveryCell Ca2PH recoveryAcid loadPump activityRenal outer medullaryDelayed activationCell acidificationRapid cell acidificationUnits/minApical membraneCell pHSustained elevationFura-2Outer medullaryExtracellular Ca2Inner stripeIntracellular Ca2Steady-state cell pHSustained increaseDimethyl-BAPTAInitial suppressionSpike increasePhysiologic ratesMicrofilament-disrupting agent
1984
Regulation of proximal bicarbonate reabsorption
Cogan MG, Alpern RJ. Regulation of proximal bicarbonate reabsorption. American Journal Of Physiology 1984, 247: f387-f395. PMID: 6148019, DOI: 10.1152/ajprenal.1984.247.3.f387.Peer-Reviewed Original Research