Effects of extracellular fluid volume and plasma bicarbonate concentration on proximal acidification in the rat.
Alpern RJ, Cogan MG, Rector FC. Effects of extracellular fluid volume and plasma bicarbonate concentration on proximal acidification in the rat. Journal Of Clinical Investigation 1983, 71: 736-746. PMID: 6826733, PMCID: PMC436924, DOI: 10.1172/jci110821.Peer-Reviewed Original ResearchConceptsNet bicarbonate absorptionExtracellular fluid volumeVolume-expanded ratsLuminal bicarbonate concentrationPlasma bicarbonate concentrationBicarbonate absorptionVolume statusFluid volumeBicarbonate concentrationProton secretionExtracellular fluid volume statusBicarbonate permeabilityFluid volume statusPeritubular bicarbonate concentrationsProximal acidificationHydropenic ratsRatsAcidotic ratsSecretionAbove inhibitionLuminal compositionAlkalosisVolume expansionTubulesMM bicarbonate