2017
Peripheral Blood Gene Expression Changes Associated With Primary Graft Dysfunction After Lung Transplantation
Diamond J, Cantu E, Porteous M, Suzuki Y, Meyer K, Lederer D, Milewski R, Arcasoy S, D'Ovidio F, Bacchetta M, Sonett J, Singh G, Costa J, Tobias J, Rodriguez H, Van Deerlin V, Olthoff K, Shaked A, Chang B, Christie J, Investigators T. Peripheral Blood Gene Expression Changes Associated With Primary Graft Dysfunction After Lung Transplantation. American Journal Of Transplantation 2017, 17: 1770-1777. PMID: 28117940, PMCID: PMC5489369, DOI: 10.1111/ajt.14209.Peer-Reviewed Original ResearchConceptsPrimary graft dysfunctionGraft dysfunctionLung transplantationPeripheral blood gene expressionFirst transplant yearImmune regulation genesInflammasome-related proteinsDays of transplantBlood of patientsAdaptive immunity genesBlood gene expressionAllograft reperfusionTransplant yearClinical trialsPGD developmentGrade 3T cellsTransplantGene expressionHypothesis-driven genesRNA expressionGene expression changesReperfusionAllograftsPatients
2013
Gene Set Enrichment Analysis of Bronchial Alveolar Lavage Fluid Identifies Key Innate Immune Pathways in Primary Graft Dysfunction after Lung Transplantation
Cantu E, Lederer D, Meyer K, Milewski R, Suzuki Y, Shah R, Diamond J, Meyer N, Tobias J, Baldwin D, Van Deerlin V, Olthoff K, Shaked A, Christie J. Gene Set Enrichment Analysis of Bronchial Alveolar Lavage Fluid Identifies Key Innate Immune Pathways in Primary Graft Dysfunction after Lung Transplantation. The Journal Of Heart And Lung Transplantation 2013, 32: s41-s42. DOI: 10.1016/j.healun.2013.01.908.Peer-Reviewed Original ResearchGraft dysfunctionGene Set Enrichment AnalysisNontypeable Hemophilus influenzaeLung transplant patientsPrimary graft dysfunctionAffymetrix Human Gene 1.0 ST arraysHours of reperfusionToll-like receptorsIL-1 receptorHuman Gene 1.0 ST arraysEnrichment analysisOrgan transplantation studiesCase-control designLung transplantationTransplant patientsLung injuryRecipient diagnosisTLR-9Lavage fluidClinical trialsDonor ageTLR pathwayHemophilus influenzaeImmune pathwaysMRNA expression