1997
The Nicolas Andry Award-1995 Fracture Healing; Radiation Induced Alterations
Pelker R, Friedlaender G. The Nicolas Andry Award-1995 Fracture Healing; Radiation Induced Alterations. Clinical Orthopaedics And Related Research® 1997, 341: 267-282. PMID: 9269183, DOI: 10.1097/00003086-199708000-00038.Peer-Reviewed Original ResearchConceptsIncidence of fracturesNonunion of fracturesDose fractionation schemesRadiation-Induced AlterationsNicolas Andry AwardSingle doseFractionation schemeClinical observationsAllogeneic boneFracture healingIrradiated boneControl groupFinal repairIncidenceInduced alterationsRat femur modelNonunionDegree of delayFracturesImmature levelBoneRepairEffects of radiationAnimalsRefracture
1993
Effects of prefracture irradiation on the biomechanical parameters of fracture healing
Widmann R, Pelker R, Friedlaender G, Panjabi M, Peschel R. Effects of prefracture irradiation on the biomechanical parameters of fracture healing. Journal Of Orthopaedic Research® 1993, 11: 422-428. PMID: 8326449, DOI: 10.1002/jor.1100110315.Peer-Reviewed Original ResearchPosterior Element Strength Six Months Postinjury in the Canine Cervical Spine
Southern E, Pelker R, Crisco J, Panjabi M. Posterior Element Strength Six Months Postinjury in the Canine Cervical Spine. Clinical Spine Surgery A Spine Publication 1993, 6: 155-161. PMID: 8504228, DOI: 10.1097/00002517-199304000-00010.Peer-Reviewed Original ResearchConceptsMaximum loadPosterior elementsExtensive surgery groupTension loadingCervical spine injuryC4-C5 levelDestructive testingRange of motionWeeks of healingDecreased stiffnessSurgery groupSham procedureSpine injuriesCanine cervical spineCervical spineIntervertebral levelSix monthsHealing periodInterspinous ligamentLoadControl valuesMotion testingBiomechanical propertiesBiomechanical studyInferior articular facets
1991
Postfracture irradiation effects on the biomechanical and histologic parameters of fracture healing
Brown R, Pelker R, Friedlaender G, Peschel R, Panjabi M. Postfracture irradiation effects on the biomechanical and histologic parameters of fracture healing. Journal Of Orthopaedic Research® 1991, 9: 876-882. PMID: 1919851, DOI: 10.1002/jor.1100090614.Peer-Reviewed Original ResearchConceptsFracture healingControl fracturesDelay groupMature Sprague-Dawley ratsClosed femoral fracturesLong-term resultsSprague-Dawley ratsContralateral intact femurFemoral fracturesHistologic parametersLocal irradiationFracture repairFractured femurRadiation exposureWeeksIntact femurBiomechanical propertiesRatsDeleterious effectsShort-term deleterious effectsFemurDaysFracturesHealingGroupThe influence of ibuprofen on fracture repair: Biomechanical, biochemical, histologic, and histomorphometric parameters in rats
Huo M, Troiano N, Pelker R, Gundberg C, Friedlaender G. The influence of ibuprofen on fracture repair: Biomechanical, biochemical, histologic, and histomorphometric parameters in rats. Journal Of Orthopaedic Research® 1991, 9: 383-390. PMID: 2010842, DOI: 10.1002/jor.1100090310.Peer-Reviewed Original ResearchConceptsControl animalsHistomorphometric parametersFracture repairUnilateral femur fracturesMature Sprague-Dawley ratsSerum osteocalcin levelsCyclo-oxygenase inhibitorSprague-Dawley ratsBone formation rateInfluence of ibuprofenOral doseFemur fracturesOsteocalcin levelsClinical practiceBone volumeBone remodelingInhibitory effectSignificant alterationsFracture biomechanicsRatsAnimalsTail vertebraePresent studyIbuprofenRepair
1990
Functional Stability of the Canine Cervical Spine After Injury
BÜFF H, PANJABI M, SONU C, CRISCO J, OXLAND T, PELKER R. Functional Stability of the Canine Cervical Spine After Injury. Spine 1990, 15: 1040-1046. PMID: 2263969, DOI: 10.1097/00007632-199015100-00011.Peer-Reviewed Original ResearchConceptsCervical spineWeeks postinjuryCanine modelPre-injury valuesTime of surgeryC4-C5 levelMuscle spasmClinical instabilitySpinal levelDestabilizing injurySpinal instabilityDecreased rangeCanine cervical spineSevere injuriesDifferent injuriesHuman cervical spineInjuryNatural historyFacetectomySpinePostinjurySignificant differencesHuman situationThe Injured Canine Cervical Spine After Six Months of Healing
CRISCO J, PANJABI M, WANG E, PRICE M, PELKER R. The Injured Canine Cervical Spine After Six Months of Healing. Spine 1990, 15: 1047-1052. PMID: 2263970, DOI: 10.1097/00007632-199015100-00012.Peer-Reviewed Original ResearchConceptsC4-C5 levelCervical spineMonths of healingDegree of severityFlexion-extension rangeCommon siteSpinal injuryInjury severityCanine cervical spineCanine modelControl groupIntervertebral motionBiomechanical testingSpineMonthsBiomechanical characteristicsInjurySeverityCanine spineHealingLateral bendingVivo behaviorAxial rotationPure momentsSimilar results
1989
Biomechanics of the rabbit cervical spine as a function of component transection
Wetzel F, Panjabi M, Pelker R. Biomechanics of the rabbit cervical spine as a function of component transection. Journal Of Orthopaedic Research® 1989, 7: 723-727. PMID: 2760744, DOI: 10.1002/jor.1100070513.Peer-Reviewed Original ResearchTemporal biomechanics of posterior cervical spine injuries in vivo in a rabbit model
Wetzel F, Panjabi M, Pelker R. Temporal biomechanics of posterior cervical spine injuries in vivo in a rabbit model. Journal Of Orthopaedic Research® 1989, 7: 728-731. PMID: 2760745, DOI: 10.1002/jor.1100070514.Peer-Reviewed Original ResearchConceptsFlexion-extension radiographsInjury groupPreinjury levelRabbit modelAcute spinal instabilityCervical spine injuryRange of motionInjury 2Preinjury valuesInjury 3Spine injuriesC4-5Injury 1Spinal instabilitySevere injuriesHealing periodInjuryWeeksGreater decreaseMean rangeRadiographsSpineBiomechanical criteriaBiomechanical behaviorGroupAllograft incorporation: A biomechanical evaluation in a rat model
Pelker R, McKay J, Troiano N, Panjabi M, Friedlaender G. Allograft incorporation: A biomechanical evaluation in a rat model. Journal Of Orthopaedic Research® 1989, 7: 585-589. PMID: 2786956, DOI: 10.1002/jor.1100070417.Peer-Reviewed Original ResearchConceptsLewis ratsLevel of freezingImmunologic responseSprague-Dawley rat femursRat modelImmune responseAllogeneic boneFresh allograftsOsteosynthesis siteBiomechanical evaluationBiomechanical testingBiologic responseSubsequent healingAllograftsRat femurRatsIntact boneBoneFemurSignificant levelsResponseTransplantationTransplantGraftWeeksThe effect of radiation on the fracture repair process. A biomechanical evaluation of a closed fracture in a rat model
Markbreiter L, Pelker R, Friedlaender G, Peschel R, Panjabi M. The effect of radiation on the fracture repair process. A biomechanical evaluation of a closed fracture in a rat model. Journal Of Orthopaedic Research® 1989, 7: 178-183. PMID: 2918417, DOI: 10.1002/jor.1100070204.Peer-Reviewed Original ResearchConceptsRat modelFemoral midshaft fractureBiomechanical parametersFracture repair processFracture healing processOpen fracture modelSingle doseMidshaft fracturesIntramedullary pinningClosed fracturesNormal controlsFracture healingControl groupNormal levelsSimilar fracturesBiomechanical evaluationHealing processExperimental groupWeeksFracturesRepair processTemporal progressionGroupEffects of radiationPrevious studies
1988
Biomechanics of Healing of Posterior Cervical Spinal Injuries in a Canine Model
PANJABI M, PELKER R, CRISCO J, THIBODEAU L, YAMAMOTO I. Biomechanics of Healing of Posterior Cervical Spinal Injuries in a Canine Model. Spine 1988, 13: 803-807. PMID: 3194789, DOI: 10.1097/00007632-198807000-00016.Peer-Reviewed Original ResearchConceptsRelative ROMCervical spineCanine modelC4-C5Cervical spinal injuryC4-C5 levelInjury 2Weeks postinjuryInjury 3C5-6Injury 1Spinal injuryAnimal studiesDecreased rangeSpinal stabilityFlexion/extensionHuman cervical spineInjuryInterspinous ligamentNatural historyShamTime pointsTime postVivo experimentsC3-C4
1985
Effect of freezing on histologic and biomechanical failure patterns in the rabbit capital femoral growth plate
Lee K, Pelker R. Effect of freezing on histologic and biomechanical failure patterns in the rabbit capital femoral growth plate. Journal Of Orthopaedic Research® 1985, 3: 514-515. PMID: 4067709, DOI: 10.1002/jor.1100030415.Peer-Reviewed Original ResearchEffects of short‐term Cyclosporin‐A on biomechanical properties of intact and fractured bone in the rat
Warren S, Pelker R, Friedlaender G. Effects of short‐term Cyclosporin‐A on biomechanical properties of intact and fractured bone in the rat. Journal Of Orthopaedic Research® 1985, 3: 96-100. PMID: 3981300, DOI: 10.1002/jor.1100030112.Peer-Reviewed Original ResearchConceptsControl animalsSolid organ allograft survivalFracture repairCurrent biomechanical dataOrgan allograft survivalShort-term cyclosporinBiomechanical propertiesSolid organ transplantationEffect of cyclosporinShort-term clinical useMidshaft femoral fractureNew immunosuppressant drugsAllograft survivalFemoral fracturesBone turnoverRat modelSkeletal toxicityOrgan transplantationSystemic effectsHistomorphometric studyImmunosuppressant drugsIntramedullary pinBiologic effectsFractured femurCyclosporinShear Fractures Through the Capital Femoral Physis of the Skeletally Immature Rabbit
Rudicel S, Pelker R, Lee K, Ogden J, Panjabi M. Shear Fractures Through the Capital Femoral Physis of the Skeletally Immature Rabbit. Journal Of Pediatric Orthopaedics 1985, 5: 27-31. PMID: 3980706, DOI: 10.1097/01241398-198501000-00006.Peer-Reviewed Original ResearchHistologic Patterns of Capital Femoral Growth Plate Fracture in the Rabbit
Lee K, Pelker R, Rudicel S, Ogden J, Panjabi M. Histologic Patterns of Capital Femoral Growth Plate Fracture in the Rabbit. Journal Of Pediatric Orthopaedics 1985, 5: 32-39. PMID: 3980707, DOI: 10.1097/01241398-198501000-00007.Peer-Reviewed Original ResearchChemotherapy‐induced alterations in the biomechanics of rat bone
Pelker R, Friedlaender G, Panjabi M, Markham T, Hausman M, Doganis A, McKay J. Chemotherapy‐induced alterations in the biomechanics of rat bone. Journal Of Orthopaedic Research® 1985, 3: 91-95. PMID: 3981299, DOI: 10.1002/jor.1100030111.Peer-Reviewed Original ResearchDimensions of the rabbit femur during growth.
Rudicel S, Lee K, Pelker R. Dimensions of the rabbit femur during growth. American Journal Of Veterinary Research 1985, 46: 268-9. PMID: 3970437.Peer-Reviewed Original Research
1984
Biomechanical and Histological Correlations in Growth Plate Failure
Moen C, Pelker R. Biomechanical and Histological Correlations in Growth Plate Failure. Journal Of Pediatric Orthopaedics 1984, 4: 180-184. PMID: 6199372, DOI: 10.1097/01241398-198403000-00006.Peer-Reviewed Original ResearchRadiation‐induced alterations of fracture healing biomechanics
Pelker R, Friedlaender G, Panjabi M, Kapp D, Doganis A. Radiation‐induced alterations of fracture healing biomechanics. Journal Of Orthopaedic Research® 1984, 2: 90-96. PMID: 6491804, DOI: 10.1002/jor.1100020114.Peer-Reviewed Original Research