2022
Comprehensive Analysis of Metabolic Isozyme Targets in Cancer
Marczyk M, Gunasekharan V, Casadevall D, Qing T, Foldi J, Sehgal R, Shan NL, Blenman KRM, O'Meara TA, Umlauf S, Surovtseva YV, Muthusamy V, Rinehart J, Perry RJ, Kibbey R, Hatzis C, Pusztai L. Comprehensive Analysis of Metabolic Isozyme Targets in Cancer. Cancer Research 2022, 82: 1698-1711. PMID: 35247885, PMCID: PMC10883296, DOI: 10.1158/0008-5472.can-21-3983.Peer-Reviewed Original ResearchConceptsPotential therapeutic targetAcetyl-CoA carboxylase 1Therapeutic targetCancer typesCell linesBreast cancer viabilityPatient-derived xenograftsNovel metabolic targetsCorresponding cell linesExpression patternsDrug treatmentMatching normal tissuesRelated commentaryTumor growthMalignant transformationSmall molecule inhibitionCancer viabilityCancer Cell Line EncyclopediaNormal tissuesMetabolic vulnerabilitiesCarboxylase 1Anticancer therapyCellular changesCell proliferationMetabolic reprogramming
2020
120-LB: Small Molecule Activator of Pyruvate Kinase Regulates In Vivo Glucose Homeostasis
ABULIZI A, CARDONE R, SIEBEL S, KUNG C, KIBBEY R. 120-LB: Small Molecule Activator of Pyruvate Kinase Regulates In Vivo Glucose Homeostasis. Diabetes 2020, 69 DOI: 10.2337/db20-120-lb.Peer-Reviewed Original ResearchEndogenous glucose productionNonalcoholic fatty liver diseaseWhole-body insulin sensitivityHFD-fed ratsInsulin sensitivityAgios PharmaceuticalsRegular chowInsulin resistanceBody weightInsulin-stimulated peripheral glucose uptakeGlucose productionHigh-fat diet ratsHyperinsulinemic-euglycemic clamp studiesSmall molecule activatorsMuscle triglyceride contentSevere liver dysfunctionFatty liver diseasePeripheral insulin sensitivityAmerican Diabetes AssociationWhole-body energy expenditurePeripheral glucose uptakeHigh-fat dietType 2 diabetesFat diet ratsPotential therapeutic target