Cyclophilin D-Dependent Mitochondrial Proton Leak in ß Cells Promotes Basal Insulin Secretion
ALSABEEH N, TADDEO E, WIKSTRÖM J, RITOU E, STILES L, KIBBEY R, LIESA M, SHIRIHAI O. Cyclophilin D-Dependent Mitochondrial Proton Leak in ß Cells Promotes Basal Insulin Secretion. Diabetes 2018, 67 DOI: 10.2337/db18-312-lb.Peer-Reviewed Original ResearchMitochondrial proton leakProton leakPermeability transition poreInhibition of CypDBasal hypersecretionCyclophilin DMolecular mechanismsInsulin secretionTransition poreGenetic inhibitionHigh-fat diet animalsAmino acidsDevelopment of diabetesHypersecretion of insulinNovel targetBeta-cell failureBasal insulin secretionBasal hyperinsulinemiaFatty acidsPrediabetic subjectsPrediabetic animalsLow conductance stateBlood glucoseBasal secretionPharmacological stimulation